1. PERSONAL INFORMATION: Name: Zahra-Soheila Soheili Date of birth: 21/09/1966 Present Position: Associate professor Address: National Institute of Genetic Engineering and Biotechnology (NIGEB), Shahrak-e- Pajoohesh, 15th Km, Tehran -Karaj Highway, Tehran, Iran. P.O. Box: 14965 -161 Tel: 0098- 21- 44 787 379 Fax: 0098- 21- 44 787 399 E-mail: soheili@nigeb.ac.ir, zssoheili@gmail.com Web Page: www.nigeb.ac.ir 2. EDUCATION: Ph.D., 1992-2000 PhD in Biochemistry: Institute of Biochemistry and Biophysics university of Tehran M.Sc., 1989 -1991 M.Sc. In Biochemistry: Institute of Biochemistry and Biophysics university of Tehran B.Sc., 1984 - 1988 Bachelor of Cell and Molecular Biology: Faculty of Sciences university of Tehran. 3. EMPLOYMENT (Present & Previous Positions): 1-Laboratory supervisor: Biophysics and Molecular Biology lab. Institute of Biochemistry and Biophysics university of Tehran 1992-1996. 2-Post doctoral fellowship at U268 INSERM, Paris France 2002-2003 3-Faculty member, National Institute of Genetic Engineering and Biotechnology (NIGEB), 2001 until now 4- Head of research office, National Institute of Genetic Engineering and Biotechnology (NIGEB), 2004-2008 5- Head of Molecular Medicine group, NIGEB, March 2014 until March 2016 6- Director, Institute of Medical Biotechnology, Since 2020 4. RESEARCH PROJECTS: 1- Retinal pigment epithelium cell culture on amniotic membrane as a promise for the treatment of age-related macular degeneration (ARMD). 2- Human RPE cell culture and evaluating the effect of amniotic fluid on growth, trans-differentiation and dedifferentiation of RPE cells. 3- Studying molecular epidemiology of HIV-1 in Iranian positive blood donor. 4- Production of retinal bio-implant. 5- Human RPE cell culture and evaluating the effect of Electro-Magnetic Field on growth, trans-differentiation and dedifferentiation of RPE cells. 6- Retinal stem cell culture on nanofibers, gene expression analysis and following up visual acuity improvement in animal models with (unilateral) macular degeneration. 7- Investigation of the effects of Bevacizumab and anti-CTGF antibody on growth and apoptosis of human retinal pigment epithelial cells (RPE) and their specific criteria in primary cell culture. 8- Ex vivo culture of human corneal endothelial cells. 9- In vivo evaluation of Pax6 overexpression in converting of murine retinal differentiated cells to retinal progenitor cells. 10- Reprogramming retinal pigment epithelial cells to produce photoreceptors by over-expression of microRNA-183 cluster. 11- GRP78/BiP overexpression in Retinal Pigmented Epithelial (RPE) cells and assessment its effect on phagocytosis of rhodopsin aggregates. 12- Identification of miR-96 signature and mechanisms associated with retinal neurodegeneration in diabetic retinopathy. 13- Study of optogenetic strategies to induce differentiation of mesenchymal stem cells and mouse retinal pigmented epithelial cells neural retina cells. 14- Design, construction and validation of engineered red OptomGluR6 as an optogenetic tool for restoring the ON switch in retinal degenerative diseases. 15- Studying the functional mechanism of miR-183 cluster in differentiation of retinal neurons from human retinal pigment epithelial (hRPE) cells; prediction and nomination of target genes. 16- The Expression of Sflt01-Anti Ang2 Molecule in Retinal Explant Tissue and Evaluation of Its Function Against Angiogenesis. 5. INTERNATIONAL/NATIONAL GRANTS: 1- A national grant for the project entitled of “Studying molecular epidemiology of HIV-1 in Iranian positive blood donor” has been allocated by Iranian Blood Transfusion Organization. The designated amount is about 45000$. 2-A national grant for the project entitled of “Production of Retinal Bio-implant” By the Council for Stem Cell Sciences and Technologies. The designated amount was about 20000$. 3- An international grant has been allocated by ICGEB(Dec.2017) for the project entitled of” Studying the functional mechanism of miR-183 cluster in differentiation of retinal neurons from human retinal pigment epithelial (hRPE) cells; prediction and nomination of target genes”. The designated amount was about 18000€. 4- A national grant for the project entitled of “Design, construction and validation of engineered red Opto-mGluR6 as an optogenetic tool for restoring the ON switch in retinal degenerative diseases” from the National Institute for Medical Research Development”, NIMAD, Sept 2018- Sep 2021. The designated amount was about 35000$. One national grant for a Post-doctoral student project from INSF (Iran National Science Foundation), that is ongoing. 2 national grants for PhD students’ projects from INSF (Iran National Science Foundation), ongoing projects. 6. AWARDS / Merits: 1-Winner of award for having achieved the highest grade point average (17.84 of 20) among all master degree graduates in Biochemistry at the University of Tehran in 1993. The award was signed and given by the president of Iran. 2- “First Rank Award” for an oral presentation; 5th IRAVO (Iranian Research Association for Vision and Ophthalmology) congress, March 5-6 2015 3- “First Rank Award” for an oral presentation; the first IRAVO (Iranian Research Association for Vision and Ophthalmology) congress, 7th Oct 2010 (A Laptop) 4- “First Rank Award” for an oral presentation; 7th IRAVO (Iranian Research Association for Vision and Ophthalmology) congress, April 13, 2017. 5- “Second Rank Award” for an oral presentation; 9th IRAVO (Iranian Research Association for Vision and Ophthalmology) congress, April, 2019. 6- “First Rank Award” for an oral presentation; 10th IRAVO (Iranian Research Association for Vision and Ophthalmology) congress, Feb 17, 2021. 7- “Second Rank Award” for an oral presentation; 10th IRAVO (Iranian Research Association for Vision and Ophthalmology) congress, Feb 17, 2021. 8- “First Rank Award” for an oral presentation; 11th IRAVO (Iranian Research Association for Vision and Ophthalmology) congress, Feb 24-25, 2022. 9- “Cinnagen Award” for an oral presentation; 11th IRAVO (Iranian Research Association for Vision and Ophthalmology) congress, Feb 24-25, 2022. MEMBERSHIPS 1- Iranian Biochemical Society membership. 2- Iranian Biotechnology Society membership. 3- European Society of Retina Specialists membership. 7. WORKSHOPS ORGANIZED/ PARTICIPATED: 1- Mouse Genetics; Models for Human Diseases, 16-19-March 2015, Trieste, Italy, ICGEB 2- RNA Metabolism; Changing Paradigms in Neurodegeneration, 26-29 May 2014, Trieste, Italy, ICGEB 8. PUBLICATIONS: 1-H. Mirzadeh, M.T. Khorasani, A.A. Katbab, R.P. Burford, Z. Soheili, A. Golestan and B. Goliaei. Biocompatibility evaluation of laser induced Aam and HEMA Graft Epr: part 1: invitro study, Clinical Material. 1994, 16:177-187. 2-B. Goliaei, Z. Soheili, A. Behboodi, S. Samiei, Hematopoiesis in the presence of macrophage in long term bone marrow culture. Experimental Hematology. 1995, 23:1115-1120. 3-Bahram Goliaei, Zahra Soheili. The Behavior of Heat Treated Bone Marrow Cells in The Long Term Bone Marrow Cultures. International Journal of Hyperthermia. 1999, 15:409-418. 4-Zahra Soheili, Bahram Goliaei. TGF-beta2 up-regulates GM-CSF Gene Expression in Human Bladder Carcinoma Cell Line HTB 5637. Med. J. I.R.I. 2002, 15(4);219-225. 5- Golaei, B., Rafiei, M., Soheili, Z. Effects of hyperthermia on the differentiation and growth of K562 erythroleukemic cell line. Leukemia Research. 2004, 28(12):1323-1328. 6- Soheili, Z. S., Minuchehr, Z. Molecular Motors. Modern Genetics. 2005. Winter (1) 25- 29. 7- Soheili, Z. S., Samiei, Sh. Real –Time PCR, principle and Application. Hepatitis Monthly, 2005, 5(3) 83-87. 8- Soheili, Z. S., Samiei, Sh., Kavari, M., Attaei, Z. A case report of thrombophilia emanated from G20210 prothrombin mutation. The Blood, a studious quarterly journal from Iranian Blood Transfusion Organization Publications. 2005 Winter, No. 2, 1027-9520. 9- Salimian, M., Soheili, Z., Goliaei, B. Production of Antibody against P388D1 cells. Kashan University of Medical Sciences & Health Services, The Feyz Journal, 2005, 8(32): 6-14. 10- Zahra- Soheila Soheili, Zarrin Minuchehr, Shahram Samiei, Zahra Ataei, Mahnaz Kavari, Ali Talebian. Studying PI3K Isoforms Gene Expression Pattern in Human Prostate Cell lines PC3 and DU145. Kashan University of Medical Sciences & Health Services, The Feyz Journal, 2007, 10 (3): 1-8. 11- Ali Akbar Pourfathollah, Mostafa Haji Molla Hoseini, Soheila Soheili, Minoo Mohraz, Sedighe Amini, Mahnaz Aghaiepour, Shahram Samiee, Prevalence of Hepatitis G Virus in HIV Infected Patients in Tehran Province. Kashan University of Medical Sciences & Health Services, The Feyz Journal, 2007, 11(1): 45-50. 12- Zahra- Soheila Soheili, Ali Ahmadi, Sedighe Amini Kafiabadi, Zahra Ataei, Mahnaz Kavari, Mohammad Soltanpour, Minoo Ahmadi-Nejad, Shahram Samiei, Ali Talebian. The Prevalence of Methylenetetrahydrofolate Reductase C677T Mutation in Deep Vein Thrombotic Patients. Modern Genetics Journal, 2007, 2 (2):61-65. 13- Haji-Molla-Hoseini Mostafa, Pourfathollah Ali-Akbar, Soheili Zahra, Mohraz Minoo, Amini Sedigheh, Aghaiepour Mahnaz, Samiee Shahram, Nikoogoftar Mahin and Moghtadaie Mina. Soluble CD26 and CD30 Plasma Levels in HIV Infected Patients with and Without GB Virus Type C Coinfection. Pakistan Journal of Biological Sciences. 2007, 10 (12): 2014-2019. 14- Mostafa Haji Molla Hoseini, Ali-Akbar Pourfathollah, Minoo Mohraz, Zahra Soheili, Sedigheh Amini, Mahnaz Aghaiepour, Shahram Samiee, Mahin Nikoogoftar, Reza Meshkani. Evaluation of Circulating Natural Type 1 Interferon-producing Cells in HIV/GBV-C and HIV/HCV Coinfected Patients: A Preliminary Study. Arch Med Res. 2007, 38 (8):868-75 15- Sajadi SM, Samiei SH, Kheirandish M, Ataei Z, Meshkani R, Kavari M, RTootian S, Soheili Z, Tabatabaei MR. The association of FXIII Va134Leu polymorphism with thrombotic events in patients referring to Iranian Blood Transfusion Organization, The Blood, a studious quarterly journal from Iranian Blood Transfusion Organization Publications, 2007 Winter, 4(4): 247-252. 16-Mohammad Soleyman Soltanpour, Zahra Soheili, Ali Akbar Pourfathollah, Shahram Samiei, Reza Meshkani, Mohammad, Reza Deyhim, Majid Safa, Zahra Ataei. The Association between Common C677T Mutation in Methylenetetrahydrofolate Reductase Gene and Risk of Venous Thrombosis in an Iranian Population. LABMEDICINE 2008, 39 (2): 5-8. 17-Mojtaba Emadi Baigi, Zahra Soheila Soheili, Shahram Samei. Evaluating the expression of Snail genes in prostate cancer. Kashan University of Medical Sciences & Health Services, The Feyz Journal 2008, 12(3): 40-46. 18- Zahra- Soheila Soheili, Zahra Ataei, Samiramis Tootian, Maryam Zadsar, Sedighe Amini Kafiabadi, Valerie Gauvin, Patricia Pinson, Herve Fleury, Shahram Samiei. Presence of HIV-1 CRF_AD in Iran, Aids Research and Human Retrovirus, 2009; 25(1):123-4 19- Ehsan Dehnavi, Zahra-Soheila Soheili, Shahram Samiei, Zahra Ataei, and Hajar Aryan. The Effect of TGF-β2 on MMP-2 Production and Activity in Highly Metastatic Human Bladder Carcinoma Cell Line 5637. Cancer Investigation, 2009, 27(5):568-74. 20- Miri-Moghaddam E, Deezagi A, Soheili ZS., Downregulation of telomerase activity in human promyelocytic cell line using RNA interference. Ann Hematol. 2009, 88(12):1169-76. 21- Ebadi P, Karimi MH, Pourfathollah AA, Saheb Ghadam Lotfi A, Soheili ZS, Samiee S, Hajati S, Nadali F, Geramizadeh B, Moazzeni SM. The Efficiency of CD40 Down Regulation by siRNA and Antisense ODN: Comparison of Lipofectamine and FuGENE6. Iran J Immunology. 2009, 6(1):1-11. 22- Karimi MH, Ebadi P, Pourfathollah AA, Moazzeni SM, Soheili ZS, Samiee S, Ataee Z, Tabei SZ, Nadali F. Tolerance Induction by CD40 Silenced Densritic Cells through Antisence. Iranian Red Crescent Medical journal. 2009, 11(3): 1-9 23- Karimi MH, Ebadi P, Pourfathollah AA, Soheili ZS, Samiee S, Ataee Z, Tabei SZ, Moazzeni SM. Immun Modulation through RNA interference Mediated Silencing of CD40 in Dendritic Cells. Cellular Immunology. 2009, 259(1):74-81 24- Akrami H, Soheili ZA, Khalooghi K, Ahmadieh H, Rezaei-Kanavi M, Samiei S, Davari M, Ghaderi S, Sanie-Jahromi F. Retinal Pigment Epithelial Cell Culture; A Potential Source for Retinal Stem Cells. Journal of Ophthalmic and Vision Research. 2009, 4(3): 134–141. 25-Deezagi A, Manteghi S, Khosravani P, Vaseli-Hagh N, Soheili ZS. Induced apoptosis by mild hyperthermia occurs via telomerase inhibition on the three human myeloid leukemia cell lines: TF-1, K562, and HL-60. Leuk Lymphoma. 2009, 50(9):1519-27. 26- Safaralizadeh R, Soheili ZS, Moin M, Dizaji AK, Pourpak Z, Samiei S.FcεRI-α siRNA Inhibit the antigen-induced activation of MC/9 cells., Iranian Journal of Allergy, Asthma and Immunology. 2009, 8(4): 177-183. 27- Emadi Baygi M, Soheili ZS, Schmitz I, Sameie S, Schulz WA.Snail regulates cell survival and inhibits cellular senescence in human metastatic prostate cancer cell lines. Cell Biol. Toxicol. Cell Biology and Toxicology, 2010, 26(6): 553-567. . 28- Emadi Baygi M., Soheili Z.S., Essman F., Dizaji A., Engers R., Goering W, Schulz W.A. Slug/SNAI2 regulates cell proliferation and invasiveness of metastatic prostate cancer cell lines. Tumor Biol. 2010, 31(4):297-307. 29-Karimi, M.H., Ebadi, P., Pourfathollah, A.A., Soheili, Z.S., Moazzeni, S.M. CD40 expression in Wehi-164 cell line. Cytotechnology, 2010,62(3):195-9. 30- Miri-Moghaddam E, Deezagi A, Soheili ZS., Apoptosis and reduced cell proliferation of HL-60 cell line caused by human telomerase reverse transcriptase inhibition by siRNA. Acta Hematologica. 2010, 124: 72-78 31- Hassan Akrami; Zahra Soheila soheili, PhD; Majid Sadeghizadeh; Keynoush Khalooghi; Hamid Ahmadieh; Mojgan Rezaie Kanavi; Shahram Samiei; Jalil Pakravesh, Title: Evaluation of RPE65, CRALBP, VEGF, CD68 and tyrosinase gene expression in Human Retinal Pigment Epithelial cells cultured on amniotic membrane. Biochemical Genetics. 2011, 49(5-6):313-22. 32- Hassan Akrami; Zahra- Soheila Soheili, Majid Sadeghizadeh, Hamid Ahmadieh, Mozhgan Rezaie Kanavi, Shahram Samiei, Keynoush Khalooghi, PlGF Gene Knockdown in Human Retinal Pigment Epithelial Cells. Graefe's Archive for Clinical and Experimental Ophthalmology, 2011, 249(4):537-46. 33- Mohammad Hossein Karimi, Padideh Ebadi, Ali Akbar Pourfathollah, Mohammad Moazzeni, Zahra Soheila Soheili, and Shahram Samiee. Comparison of Three Techniques for Generation of Tolerogenic Dendritic Cells: siRNA, Oligonucleotide Antisense, and Antibody Blocking. HYBRIDOMA. 2010, 29(6): 473-480. 34- Shima Ghaderi, Zahra-Soheila Soheili, Hamid Ahmadieh, Maliheh Davari, Fatemeh Sanie Jahromi, Shahram Samiei, Mojgan Rezaie-Kanavi, Jalil Pakravesh, Abdolkhalegh Deezagi, Human Amniotic Fluid Promotes Retinal Pigmented Epithelial Cells' Trans-differentiation into Rod Photoreceptors and Retinal Ganglion Cells. Stem cells and development, 2011, 20(9):1615-25. 35-Zare, M., Jazii, F.R., Soheili, Z.-S., Moghanibashi, M.-M., Downregulation of tropomyosin-1 in squamous cell carcinoma of esophagus, the role of Ras signaling and methylation . Molecular Carcinogenesis. 2012, 51(10):796-806. 36-Mohammad Soleyman Soltanpour , Zahra Soheili, Ali Akbar Pourfathollah , Shahram Samiei Reza MeshkaniAli Asghar Kiani , Safa Majid , Zahra Ataei , Mahnaz Kavari, The A1298C Mutation in Methylenetetrahydrofolate Reductase Gene and Its Association With Idiopathic Venous Thrombosis in an Iranian Population. LabMedicine. 2011, 42, 213-216 37- Fahimeh Piryaei, Massoud Houshmand, Omid Aryani, Sepideh Dadgar, Zahra-Soheila Soheili, Association of the mitochondrial ATPase6/8 and tRNALys genes mutation with autism in Iranian patients. Cell Journal(Yakhteh). 2012, 14(2): 98. 38- Fatemeh Sanie-Jahromi, Hamid Ahmadieh, Zahra-Soheila Soheili, Maliheh Davari, Shima Ghaderi, Mozhgan Rezaei Kanavi, Shahram Samiei, Abdolkhalegh Deezagi, Jalil Pakravesh, Abouzar Bagheri, Enhanced generation of retinal progenitor cells from human retinal pigment epithelial cells induced by amniotic fluid. BMC Research Notes. 2012, 5:182 39- Mehdi Moghanibashi, Ferdous Rastgar Jazii, Zahra-Soheila Soheili, Aliasghar Karkhane, Kazem Parivar, Parisa Mohamadynejad, Maryam Zare. Proteomics of a new esophageal cancer cell line established from Persian patient Gene. 2012, 500(1):124-33 40- Moghanibashi M, Rastgar Jazii F, Soheili ZS, Zare M, Karkhane A, Parivar K, Mohamadynejad P. Esophageal cancer alters the expression of nuclear pore complex binding protein Hsc70 and eIF5A-1. Funct Integr Genomics. 2013, 13(2):253-60. 41- Ramin Nourinia, Zahra-Soheila Soheili, Hamid Ahmadieh, Hassan Akrami, Mozhgan Rezaei-Kanavi, Shahram Samiei Knockdown of the Placental Growth Factor Gene Inhibits Laser Induced Choroidal Neovascularization in a Murine Model. Journal of Ophthalmic and Vision Research. 2013, 8(1): 4. 42- Maliheh Davari, zahra soheili, Hamid Ahmadieh, Fateme Sanie-Jahromi, Shima Ghaderi, Mozhgan Rezaie Kanavi, Shahram Samie, Hassan Akrami, Massoud Haghighi, and Fahimeh Javidi-Azad. Amniotic Fluid Promotes the Appearance of Neural Retinal Progenitors and Neurons in Human Retinal Pigment Epithelial Cell Cultures. Molecular Vision. 2013, 19: 2330–2342. 43- Rezanejad, Habib, Soheili, Zahra-Soheila, Haddad, Farhang, Moghadam Matin, Maryam, Samiei, Shahram, Manafi, Ali, Ahmadieh, Hamid. In Vitro Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells into Neural Retinal Cells through expression of human PAX6 (5a) Gene. Cell Tissue Res. 2014, 356(1):65-75. 44- Habib Rezanejad, Farhang Haddad, Zahra-Soheila Soheili, Maryam M. Matin, Shahram Samiei, and Sepideh Zununi Vahed. PAX6 (+5a) Expression in Adipose Tissue-Derived Stem Cells Induces Retinal Ganglion Cells. Journal of Cell and Molecular Research. 2014, 6(1):3-12. 45- Hoda Shams Najafabadi, Zahra-Soheila Soheili, Shahla Mohammad Ganji.Studying the Morphology and Growth of Human Retinal Pigment Epithelial Cells on a Thin Layer of Alginate and Alginate/Gelatin as a Culture Substrate. Modares Journal of Medical Sciences: Pathobiology. 2013, 16: 81-93. 46- Sepehr Feizi, Zahra-Soheila Soheili, Abouzar Bagheri, Sahar Balagholi, Azam Mohammadian, Mozhgan Rezaei-Kanavi, Hamid Ahmadieh, Shahram Samiei, Kambiz Negahban.Effect of amniotic fluid on the in vitro culture of human corneal endothelial cells. Experimental Eye Research. 2014 May;122:132-40. 47-Sun D, Nakao S, Xie F, Zandi S, Bagheri A, Rezaei Kanavi M, Samiei S, Soheili ZS, Frimmel S, Zhang Z, Ablonczy Z, Ahmadieh H, Hafezi-Moghadam A. Molecular imaging reveals elevated VEGFR-2 expression in retinal capillaries in diabetes: a novel biomarker for early diagnosis. FASEB J.2014 28:3942-3951. 48- Heidari R, Soheili ZS, Samiei S, Ahmadieh H, Davari M, Nazemroaya F, Bagheri A, Deezagi A. Alginate as a Cell Culture Substrate for Growth and Differentiation of Human Retinal Pigment Epithelial Cells. Appl Biochem Biotechnol. 2015, 175(5):2399-412. 49-Abouzar Bagheri, Zahra-Soheila Soheili, Hamid Ahmadieh, Shahram Samiei, Nader Sheibani, Shamila Darvishalipour Astaneh, Mozhgan Rezaei Kanavi, and Azam Mohammadian. Simultaneous application of bevacizumab and anti-CTGF antibody effectively suppresses proangiogenic and profibrotic factors in human RPE cells. Mol Vis. 2015, 21: 378–390. 50- Ensieh Darbari, Zahra Soheila- Soheili.Cloning of human SOX2 in lentiviral vector and transduction of HEK293T cell line. The Scientific Journal of Iranian Blood Transfusion Organization. 2015, 12(2): 101-110. 51-Zahra-Soheila Soheili, Hajar Aryan. Identification of PI3K Isoforms in Human Prostate Cancer Cell Lines (PC3, DU145) and Human Bladder Carcinoma Cell line (5637). Journal of Cell and Molecular Research. 2015, 7(1): 3-10. 52- Hoda Shams-Najafabadi, Zahra Soheila Soheili, Shahla Mohammad-Ganji. Behavior of a spontaneously arising human retinal pigment epithelial cell line cultivated on thin alginate film. JOVR. 2015, 10(3):286-294. 53- Saeed Tavakolifar, Sina Lasemi, Sajad Mohammadgholiha, Zahra-Soheila Soheili.Retinoic Acid Receptor Beta in Pathophysiology of Age-Related Macular Degeneration. Iran J Public Health. 2015, 44(11):1570-1571. 54- Habib Ghaznavi, Zahra Soheili, Shahram Samiei, and Mohammad Soleiman Soltanpour. Association of Methylenetetrahydrofolate Reductase C677T Polymorphism with Hyperhomocysteinemia and Deep Vein Thrombosis in the Iranian Population. Vascular Specialist International. 2015, 31:109-114. 55- Habib Ghaznavi, Zahra Soheili, Shahram Samiei, and Mohammad Soleiman Soltanpour.Role of Hyperhomocysteinemia and Methylene Tetrahydrofolate Reductase C677T Polymorphism in Idiopathic Portal Vein Thrombosis. Vascular Specialist International. 2016, 32:6-10. 56-Alivand MR, Sabouni F, Soheili ZS. Probable Chemical Hypoxia Effects on Progress of CNV Through Induction of Promoter CpG Demethylation and Overexpression of IL17RC in Human RPE Cells. Curr Eye Res. 2016 Sep;41(9):1245-54. 57- Ehsan Ranaei Pirmardan, Zahra-Soheila Soheili, Shahram Samiei, Hamid Ahmadieh, Seyed Javad Mowla, Razie Ezzati, Marzieh Naseri, Characterization of a spontaneously generated murine retinal pigmented epithelium cell line; a model for in vitro experiments. Experimental Cell Research. 2016, 347(2): 332-338. 58- Seyed Mehdi Sajjadi, Abbas Khosravi, Jalil Pakravesh, Zahra-soheila Soheili, Shahram Samiei, Saeed Mohammadi, Mohammad Ali Jalali far. Factor XIIIVal34Leu polymorphism and risk of recurrent pregnancy loss in Iranian population: a case control study. Frontiers in Biology. 2016, 11(6): 471–475. 59- Hoda Shams Najafabadi, Zahra-soheila Soheili, Shahram Samiei, Hamid Ahmadieh, Ehsan Ranaei Pirmardan, Maryam Masoomi. Isolation, Characterization and Establishment of Spontaneously Immortalized Cell Line HRPE-2S with Stem Cell Properties. Journal of cellular physiology, 2017 Oct;232(10): 2626-2640. 60-Maliheh Davari · Zahra-Soheila Soheili · Shahram Samiei ·Ehsan Ranaei Pirmardan Overexpression of miR-183/-96/-182 triggers neuronal cell fate in human retinal pigment epithelial (hRPE) cells in culture. Biochemical and Biophysical Research Communications. 2017, 483(1): 745–751 61-Saleheh Shahmoradi · Fatemeh Yazdian · Fatemeh Tabandeh ·Mona Navaei-Nigjeh, Controlled surface morphology and hydrophilicity of polycaprolactone toward human retinal pigment epithelium cells. Materials Science and Engineering: C. 2017, 73(1) :300–309 62- Nooshin Tasharrofi, Fatemeh Kouhkan, Masoud Soleimani, Zahra-Soheila Soheili, Fatemeh Atyabi, Hamid Akbari Javar, Farid Abedin Dorkoosh. Efficient gene delivery to primary human retinal pigment epithelial cells: the innate and acquired properties of vectors. International Journal of Pharmaceutics. 2017, 518(1–2): 66–79. 63- Alivand MR, Soheili ZS, Pornour M, Solali S, Sabouni F. Novel Epigenetic Controlling of Hypoxia Pathway Related to Overexpression and Promoter Hypomethylation of TET1 and TET2 in RPE Cells. J Cell Biochem. 2017;118(10):3193-3204. 64- Behnam Maleki, Fatemeh Tabandeh, Zahra-Soheila Soheili, Dina Morshedi. Application of proteinous nanofibrils to culture retinal pigmented epithelium cells: A versatile biomaterial. Reactive and Functional Polymers, 2017; 115, 36-42. 65- Fatemeh Nazemroaya, Zahra-Soheila Soheili, Shahram Samiei, Abdolkhalegh Deezagi, Hamid Ahmadieh, Malihe Davari, Razeih Heidari, Abouzar Bagheri, Shamila Darvishalipour-Astaneh- Induced Retro-differentiation of Human Retinal Pigment Epithelial Cells on PolyHEMA, Journal of Cellular Biochemistry 2017;118(10): 3080-3089. 66- Razie Ezati, Azadeh Etemadzadeh, Zahra-Soheila Soheili, Shahram Samiei, Ehsan Ranaei Pirmardan, Malihe Davari, Hoda Shams Najafabadi. The influence of rAAV2-mediated SOX2 delivery into neonatal and adult human RPE cells; a comparative study. Journal of Cellular Physiology. 2017, 233(2):1222-1235 67-Tahmineh Motevasseli, Narsis Daftarian, Mozhgan Rezaei Kanavi, Hamid Ahmadieh, Abouzar Bagheri, Seyed Bagher Hosseini. Shabnam Ansari, Zahra-Soheila Soheili Ocular Safety of Intravitreal Connective Tissue Growth Factor Neutralizing Antibody, Current Eye Research, 2017;42(8): 1194-1201. 68- Hoda Shams-Najafabadi, Zahra Soheila Soheili, Hamid Ahmadieh, Narsis Daftarian. Pharmacological treatment of wet-type Age-Related Macular Degeneration; the currenct and evolving therapies. Arch Iran Med. 2017;20(8): 0-0 69- Shima Ghaderi, Shahin Ahmadian, Zahra-Soheila Soheili, Hamid Ahmadieh, Shahram Samiei, Samira Kheitan, Ehsan Ranaei Pirmardan, AAV Delivery of GRP78/BiP Promotes Adaptation of Human RPE Cell to ER Stress. Journal of Cellular Biochemistry 2018;119(2):1355-1367. 70- Samira Kheitan, Zarrin Minuchehr, Zahra-Soheila Soheili, Exploring the cross talk between ER stress and inflammation in age-related macular degeneration PLOS one, 2017;12(7):e0181667. 72- Behnam Noorani, Fatemeh Tabandeh, Fatemeh Yazdian, Zahra-Soheila Soheili, Mehdi Shakibaie & Shiva Rahmani, Thin Natural Gelatin/Chitosan Nanofibrous Scaffolds for Retinal Pigment Epithelium Cells International Journal of Polymeric Materials and Polymeric Biomaterials, 2017; 9(21): 754-763. 73- Nooshin Tasharrofi, Fatemeh Kouhkan, Masoud Soleimani, Zahra‐Sheila Soheili, Mahboubeh Kabiri, Mohaddeseh Mahmoudi, Saber Farid, Abedin Dorkoosh, Survival Improvement in Human Retinal Pigment Epithelial Cells via Fas Receptor Targeting by miR‐374a. Journal of Cellular Biochemistry, 2017; 118(12): 4854-4861. 74- Javadi H, Lotfi AS, Hosseinkhani S, Mehrani H, Amani J, Soheili ZS, Hojati Z, Kamali M, The combinational effect of E6/E7 siRNA and anti-miR-182 on apoptosis induction in HPV16-positive cervical cells. Artif Cells Nanomed Biotechnol. 2018; 6:1-10. 75- Farinaz Behfarjam, Mohammad Hossein Sanati, Zohreh Jadali, Zahra Soheila Soheili, Siavash Nasseri Moghaddam, Mitra Ataei and Sepideh Nikfam, IFN-γ siRNA Effectively Knocked Down IFN-γ Gene Expression and Reduced Cytokine Secretion in Peripheral Blood Mononuclear Cells of Patients with Autoimmune Hepatitis. Hepatitis Monthly, 2018, 18(8): e63676. 76- Niyousha Nasrabadi, Zahra-Soheila Soheili, Abouzar Bagheri, Hamid Ahmadieh, Yashar Amizadeh, Farzin Sahebjam, Faraj Tabeie, Mozhgan Rezaei Kanavi, The Effects of Electromagnetic Fields on Cultured Human Retinal Pigment Epithelial Cells. Bioelectromagnetics. 2018;39(8):585-594. 77- Fatemeh Nafian, Mohammad Javad Rasaee, Shahin Yazdani, Zahra-Soheila Soheili, Peptide Selected by Phage Display Increases Survival of SH-SY5Y Neurons Comparable to Brain-Derived Neurotrophic Factor. Journal of Cellular Biochemistry. 2018; 120(5): 7612-7622. 78- Ehsan Ranaei Pirmardan, Zahra-Soheila Soheili, Shahram Samiei, Hamid Ahmadieh, Seyed Javad Mowla, Marzieh Naseri, Narsis Daftarian, In Vivo Evaluation of PAX6 Overexpression and NMDA Cytotoxicity to Stimulate Proliferation in the Mouse Retina. Scientific Reports, 2018; 8:17700. 79- NarsisDaftarian, ShirinRohani, Mozhgan RezaeiKanavi, FatemehSur, MehrabanMirrahimi, AliHafezi-Moghadam, Zahra-SoheilaSoheili, HamidAhmadieh. Effects of intravitreal connective tissue growth factor neutralizing antibody on choroidal neovascular membrane-associated subretinal fibrosis. Experimental Eye Research, 2019;184: 286-295. 80- Narsis Daftarian, Souska Zandi1, Golbarg Piryaie, Mahin Nikougoftar Zarif, |Ehsan Ranaei Pirmardan, Muneo Yamaguchi, Qurban Behzadian Nejad, Hossein Hasanpour, Shahram Samiei, Isabel B. Pfister, Zahra-Soheila Soheili, Shintaro Nakao, Aliaa Barakat, Justus G. Garweg, Hamid Ahmadieh, Ali Hafezi-Moghadam. Peripheral blood CD163(+) monocytes and soluble CD163 in dry and neovascular age-related macular degeneration. The FASEB Journal. 2020; 00:1–11. 81- Zahra-Soheila Soheili, Hamid Latifi-Navid. Editorial, Systems Biology for Identification of Essential Growth Factors in Retinal Regeneration. Joutnal of Ophthalmic and Vision Research, 2021; 16(1): 1-3 82-Hoda Shams Najafabadi, Mehdi Sadeghi, Mohammad Ismaeil Zibaii, Zahra-Soheila Soheili, Shahram Samiee, Pouria Ghasemi, Mohammad Hosseini, Hamid Gholami Pourbadie, Hamid Ahmadieh, Sepideh Taghizadeh, Ehsan Ranaei Pirmardan. Optogenetic control of neural differentiation in Opto-mGluR6 engineered retinal pigment epithelial cell line and mesenchymal stem cells. J Cell Biochem. 2021 Apr 13. doi: 10.1002/jcb.29918. Online ahead of print. 83- Fatemeh Sanie-Jahromi, M Hossein Nowroozzadeh, Zahra Khodabandeh, Zahra-Soheila Soheili, Zohreh Khajehahmadi, Zahra Emadi, Mohammad Reza Talebnejad. Effects of the secretome of human Wharton's jelly mesenchymal stem cells on the proliferation and apoptosis gene expression of the retinal pigmented epithelium. Exp Eye Res. 2021; 205:108528. 84- Samaneh Sepahi, Zahra-Soheila Soheili, Jalil Tavakkol-Afshari, Soghra Mehri, Seyedeh Maryam Hosseini, Seyed Ahmad Mohajeri, Elham Khodaverdi. Retinoprotective Effects of Crocin and Crocetin via Anti-angiogenic Mechanism in High Glucose-Induced Human Retinal Pigment Epithelium Cells. Curr Mol Pharmacol. 2021 Apr 19. doi: 10.2174/1874467214666210420111232. 85- Mohammad Amir Mishan, Sahar Balagholi, Tahereh Chamani, Sepehr Feizi, Zahra-Soheila Soheili, Mozhgan Rezaei Kanavi. Potential of a novel scaffold composed of human platelet lysate and fibrin for human corneal endothelial cells. Cell Tissue Bank. 2021 May 3. doi: 10.1007/s10561-021-09931-x. Online ahead of print. 86- Mohammad Amir Mishan, Sahar Balagholi, Tahereh Chamani, Sepehr Feizi, Zahra-Soheila Soheili, Mozhgan Rezaei Kanavi. Potential Effect of Human Platelet Lysate on in vitro Expansion of Human Corneal Endothelial Cells Compared with Y-27632 ROCK Inhibitor. Journal of Ophthalmic and Vision Research (JOVR) 2021; 16: 349–356. 87- Sepideh Taghizadeh, Zahra-Soheila Soheili, Mehdi Sadeghi, Shahram Samiei, Ehsan Ranaei Pirmardan, Ali Kashanian, Fahimeh Zakeri, Hamid Latifi-Navid, Hoda Shams Najafabadi. sFLT01 modulates invasion and metastasis in prostate cancer DU145 cells by inhibition of VEGF/GRP78/MMP2&9 axis. BMC Mol Cell Biol. 2021 May 19;22(1):30. 10.1186/s12860-021-00367-5. 88- Hamid Latifi-Navid, Zahra-Soheila Soheili, Shahram Samiei, Mehdi Sadeghi, Sepideh Taghizadeh, Ehsan Ranaei Pirmardan, Hamid Ahmadieh. Network analysis and the impact of Aflibercept on specific mediators of angiogenesis in HUVEC cells, Journal of Cellular and Molecular Medicine, first published: 11 July 2021 https://doi.org/10.1111/jcmm.16778 89- Fazili Narges, Soheili Zahra Soheila, Malekzadeh Shafaroudi Saeid, Sameie Shahram, Alipoor Shamila D., Moshtaghi Nasrin, Bagheri Abouzar. Royal Jelly Decreases MMP-9 Expression and Induces Apoptosis in Human 5637 Bladder Cancer Cells, JOURNAL OF CELL AND MOLECULAR RESEARCH 2021, 13(1): 36-43. 90- Mohammad Amir Mishan, Sahar Balagholi, Tahereh Chamani, Sepehr Feizi, Zahra-Soheila Soheili, Mozhgan Rezaei Kanavi. Comparative culture of human corneal endothelial cells following treatment with human platelet lysate/fibrin hydrogel versus Y-27632 ROCK inhibitor: in vitro and ex vivo study, Int Ophthalmol. 2022 Jan 13. doi: 10.1007/s10792-021-02136-x. Online ahead of print. 91- Zahrasoheila Soheili, Hamid Ahmadieh, Siamak Moradian, Shahram Samiee, Narsis Daftarian, Samira Kheitan, Shamila D. Alipoor, Abouzar Bagheri, Seyed Ghader Azizi. Susceptible Single Nucleotide Polymorphisms in Exon 10 and Intron 9 of Complement Factor H Gene in Patients with Age-related Macular Degeneration, Res Mol Med (RMM) 2021, 9(1): 61-70. 92- Hoda Shams Najafabadi, Zahra-soheila Soheili, Shahram Samiee, Hamid Ahmadieh, Ehsan Ranaei Pirmardan, Massoud Haghighi. Neural Differentiation of Human Retinal Pigment Epithelial Cells on Alginate/Gelatin Substrate, Molecula Vision, under publication. 93- Fahimeh Zakeri , Hamid Latifi-Navid , Zahra-Soheila Soheili , Mehdi Sadeghi , Seyed Shahriar Arab , Shahram Samiei , Ehsan Ranaei Pirmardan , Sepideh Taghizadeh , Hamid Ahmadieh , Ali Hafezi-Moghadam. Design, construction and in vivo functional assessment of a hinge truncated sFLT01, Gene Ther. 2022 Sep 16. doi: 10.1038/s41434-022-00362-1. Online ahead of print. 94- Bahar Safdari, Mozhgan Rezaei-Kanavi, Mohammad Amir Mishan, Hamid Ahmadieh, Zahra-soheila Soheili, Iman Slahshouri Far, Fatemeh Suri. Augmented Expression of NOGO-A and Its Receptors in Human Retinal Pigment Epithelial Cells Following Treatment with Human Amniotic Fluid, Iran J Public Health, Vol. 51, No.7, Jul2022, pp.1658-1666 9. PATENTS/REGISTRATION: 1-Application of human RPE Cell line and License agreement for sale to a Canadian biotechnology company for the following product; human RPE cell line. This cell lines have been produced by our research team. 2- A novel anti angiogenic fusion protein delivered by AAV vectors for inhibition of retinal neovascularization and reduction of intratumoral microvessel density 3- The process of Red-Opto mGlu-R6 optogenetic construct designing and construction. 4- Tri-Specific Chimeric anti angiogenic, sFLT01-anti ANG2 drug designing process. 10. PROCEEDINGS/ABSTRACTS: 28th Annual meeting of the international society for experimental Hematology July 1999 Monte Carlo, principality of Monaco Z Soheili, B Goliaei Transforming Growth factor β2 stimulates Granulocyte Macrophage –Colony stimulating factor gene expression in Human Stimulating Carcinoma Cell Line HTB 5637 22nd International Clinical Hyperthermia Society September 1999, Marina Del Rey, USAB Goliaei, R Jalal, S Khoei, Z Minuchehr, n H Rajabi, K Siamaki, Z Soheili, Hyperthermia and Colony Stimulating Factors. 18th International Congress of Biochemistry and Molecular Biology Beyond the genome July 2000 Birmingham, UK B Goliaei, Z Soheili Transforming Growth factorβ2 up-regulates GM-CSF gene in Human Bladder carcinoma cell line HTB- 5637 6th Congress of Biochemistry, October 2001, Tehran, Iran B Goliaei, N Rafatian, R Jalal, Z Soheili A Vector Containing GM-CSF Antisense B Goliaei, Z Soheili, M Salimian Antibody Prepration Against P388D1 Cells in Order to Use in Mouse Hematopoiesis Studies Z Soheili, B Goliaei, TGF-β2 Stimulates GM-CSF Gene Expression in Human Bladder Carcinoma Cell Line. ISEH 2002, 31st Annual Meeting of the International Society for Experimental Hematology. July 2002, Montreal, Canada. M Salimian, Z Soheili, B Goliaei Long Term Co-Culture of Bone Marrow Cells with Tumor Cell Line P388D1 8th Congress of the European Hematology Association, June 2003, Lyon, France M Rafiei, Z Soheili, B Goliaei The Effect of Nitric Oxide on Growth and Differentiation of K-52 Human Eryhroleukemic Cell Line. Liver Disease Congress, July 2003, Tehran, Iran N Cohan, T Zandieh, Z Ataiei, S Amini, M Kavari, S Samiei, ZS Soheili Characterization and prevalence of Occult Hepatitis B Infection in Patient with hepatitis C. HUPO 2nd Annual &IUBMB XIX World Congress, October 2003, Montreal, Canada B. Goliaie, S. Alizadeh, and Z.S. Soheili The Effect of Hyperthermia on the Human Placental Growth Hormone Gene Expression The First Congress of Iranian Scientific Association of Clinical Laboratory, January 2005, Tehran, Iran M Soltanpour, Z Soheili, A Pourfatollah, S Samiei The incidence of A1298C Mutation in MTHFR Gene among Iranian Patients with Venous Thrombosis M Haji Molla Hoseini, A Pourfatollah, S Soheili, M Mohraz, S Amini, M Aghaeipour, S Samiei Establishing a Real-Time PCR Method to Detect HIV-1RNA in Plasma 2nd Iranian Congress on Virology, February 2004, Tehran, Iran F Reihani-Sabet, ZS Soheili, S Ehsasi, P Partobargh, M Bahar, H Eftekhari, S Samiei, K Bahar Comparision of Methods for HCV Genotyping and Report of Genotyping of HCV Isolates from Iranian Patients Using PCR-Reverse Dot Blot The 4th National Biotechnology Congress of Iran. August 2005, Tehran, Iran A Deezagi, N Vaselihagh, ZS Soheili, The Effect of Heat Shock on the Activity of Telomerase in HL-60 Human Myeloid Cell Line 3rd international conference on thrombosis and hemostasis issues in cancer, October 2005 Bergamo, Italy ZS Soheili, SH Samiei, M Kavari, Z Ataei, MH Moghaddasi, A Ahmadi, T Shashaani Prevalence of G20210A and MTHFR mutation in Iranian patients with venous thromboembolism disorder The 8th Iranian Congress of Immunology and Allergy, May 2006, Tehran, Iran M Haji Molla Hoseini, A Pourfatollah, S Samiei, M Mohraz, Z Soheili, S Amini, M Aghaeipour, M Nikoogoftar To Explore the Effect of GB Virus-C Infection on CD4+ Lymphocyte Count Among Iranian Patients Infected with the Human Immunodeficiency Virus 14th National and 2nd International Conference of Biology, August Tehran, Iran 2006 S Soheili, S Samiei, V Saneei Analyzing PI3K isoforms gene expression pattern in human prostatic cell lines PC-3 and DU-145 A Sharifzadeh, ZS Soheili, S Samieiξ PI3K signaling role in regulation of MMPs activity from human prostate cell lines PC-3 and DU -145 S Manteghi, A Deezagi, ABidmeshkipoor, ZS Soheili, N Vaselihagh The Effect of Mild Hyperthermia on the Telomerase Activity in TF1 Human Myeloid Cell Lines ISTH 2007, 21th Congress of the International Society on Thrombosis and Haemostasis, July 2007, Geneva, Switzerland S Sajadi, S Samiei, M Kheirandish, Z Ataei, M Kavari, M Abdollahi, S Tootian, Z Soheili, S Tabatabaei, R Meshkani, Z Sharifi, M Jalalifar The Protective Effect of FXIII Val34Leu Polymorphism Against Venous Thrombosis in Iranian Patients The 9th Iranian Congress of Biochemistry& the 2nd International Congress of Biochemistry and Molecular Biology, October/November 2007 Shiraz, Iran K Khalooghi, H Akrami, H Ahmadieh, M Rezaei, ZS Soheili Evaluation of Different RPE Cell Isolation Methods from Human Eye Globes ZS Soheilli, S Samiei, E Dehnavi The Investigation of TGF-β 2 Signaling Pathway in GM-CSF Gene Upregulation by Human Bladder Carcinoma Cell Line 5637 ZS Soheilli, S Samiei, A Sharifzadeh, E Dehnavi The Effect of PI3K Inhibition on Secretory MMP’S Gelatinolytic Activity and Gene Expression Through Genitourinary PC3, DU145 and 5637 Cell Lines The 5th National Biotechnology Congress of Iran, November 2007, Tehran, Iran ZS Soheili, S Samiei, H Karimi, A Pourfatollah, Z Ataei, P Ebadi Relative Quantification of CD40 Gene Expression in Murine Dendritic Cells 15th Conference on Retroviruses and Opportunistic Infections CROI February 2008 Boston, USA S Samiei, ZS Soheilli and H Fleury A novel pattern of evolution of HIV- 1 subtypes/ CRFs in Iran 8th EURETINA Congress, May 2008, Vienna, Austria, Z.S. Soheili, H. Akrami, K. Khalooghi, H. Ahmadieh, M. Rezaei Kanavi, S. Samiei, Retinal pigment epithelial cell culture on amniotic membrane Z.S. Soheili, H. Akrami, K. Khalooghi, H. Ahmadieh, M. Rezaei Kanavi, S. Samiei, Generation of retinal progenitor (stem) cells from human cultured RPE cells The 9th International Congress on Cell Biology, October 2008, Seoul, Korea ZS Soheili H Aryan , H Nazem , S Samiei , Z Ataei Quantification of Phosphatidylinositol-3 Kinase Isoforms in Prostate Cancer Cell Lines, PC3 and DU145 2009 Asia- Arvo meeting, January 15-18, Heydar abad International Convention Center, Heydarabad, India Z.S. Soheili, H. Ahmadieh, H. Akrami, M. Rezaei Kanavi, K. Khalooghi, S. Samiei, Assesment of Retinal Pigment Epithelial Cell Primary Culture from Human Donors: An Age Dependent Study. 2009 ARVO International Society for Ocular Cell Biology (ISOCB), September 9-12, in Ericeira, Portugal Z.S. soheili, F. Sanie-Jahromi, H. Ahmadieh, M. Rezaiei Kanavi, M. Davari, S. Ghaderi, J. Pakravesh Amniotic Fluid; A valuable Growth Inducer for Retinal Pigment Epithelial Cell Proliferation S. Samiei, H. Akrami, H. Ahmadieh, M. Rezaie Kanavi, Z.S. Soheili, M. Sadeghizadeh Down Regulation of PlGF Reduced Angiogenic Potential in Retinal Pigment Epithelial Cell Conditioned Media ZS. soheili, S. Ghaderi, H. Ahmadieh, M. Rezaie Kanavi, M. Davari, F. Sanie-Jahromi Evaluation of in Vitro Growth Characteristics of Human Retinal Pigment Epithelial Cells Z.S. soheili, M. Davari, H. Ahmadieh, M. Rezaiei Kanavi, F. Sanie-Jahromi, S. Ghaderi, J. Pakravesh Manifestation of Stem Cell Colonies in Amniotic Fluid-treated Human Retinal Pigment Epithelial Cell Culture ISER 2010, the XIX Biennial Meeting of the International Society for Eye Research, Canada, July 18-23, 2010 Abouzar Bagheri, Zahra-Soheila Soheili, Hamid Ahmadieh, Shamila D. Alipour, Shahram Samiei, Mozhgan Rezaei, Abdolkhalegh Dizaji The Effect of Bevacizumab on MMP-2 Production and Activity in Human Retinal Pigment Epithelial Cell Culture M. Davari, H. Ahmadieh, Z.S. Soheili, F. Sanie-Jahromi, S. Ghaderi, M. Rezaie Kanavi, S. Samiei, H. Akrami, J. Pakravesh Manifestation of Retinal Neurons and Progenitors in Retinal Pigment Epithelium Cultures Treated by Amniotic Fluid Fateme Sanie-Jahromi, Zahra-Soheila Soheili, Hamid Ahmadieh, Malihe Davari, Shima Ghaderi, Mozhgan Rezaie Kanavi, Shahram Samiei, Abdolkhalegh Dizaji, J. Pakravesh Neural Progenitor Cells Arising from Amniotic Fluid (AF) treated Retinal Pigment Epithelium (RPE) Cell Cultures. Shima Ghaderi, Zahra-Soheila Soheili, Hamid Ahmadieh, Maliheh Davari, Fatemeh Sanie Jahromi, Abdolkhalegh Dizaji, Shahram Samiei, Mozhgan Rezaei-Knavi, Jalil Pakravesh, Human Amniotic Fluid Promotes Retinal Pigmented Epithelial Cells, Transdifferentiation into Rod Photoreceptors and Retinal Ganglion Cells Shima Ghaderi, Hamid Ahmadieh, Zahra-Soheila Soheili, Malihe Davar, Fateme Sanie Jahromi, Abdolkhalegh Dizaji, Shahram Samiei, Mozhgan Rezaei, Jalil Pakravesh Human Amniotic Fluid Promotes Retinal Pigmented Epithelial Cells Trans-differentiation into Rod Photoreceptors 21st International Congress on Anti-Cancer Treatment, Paris, France, 1st-5st February 2010 Deezagi A, Miri-Moghaddam E, Soheili ZS Effects of telomerase Inhibition by siRNA on Cell Proliferation and Apoptosis of Promyelocytic HL-60 Cell line, Miri-Moghaddam E, Deezagi A, Soheili ZS, Shariati P Outcome of the modulation o hTERT Gene Expression in Promyelocytic Leukemia as a mode, The First Annual Meeting of the Iranian Research Association for Vision and Ophthalmology, IRAVO, October 7, 2010 Sanie-Jahromi F, Ahmadieh H, Soheili ZS, Davari M, Ghoderi Sh, Rezaei-Kanavi M, Samie Sh, Dizaji A, Pakravesh The Effect of Amniotic Fluid (AF) on the Human Retinal Pigment Epithelial (RPE) Cell Dedifferentiontion., Sanie-Jahromi F, Ahmadieh H, Soheili ZS, Davari M, Ghoderi Sh, Rezaei-Kanavi M, Samie Sh, Dizaji A, Pakravesh, The Effect of Amniotic Fluid on Transdifferentiation and Dedifferentiation of Retinol Pigment Epithelial Cells. Ghaderi sh, Ahmadieh H, Soheili ZS, Davari M, Sanie- Jahromi F, Dizaji, A, Samie sh, Rezaei-kanavi M, Pakravesh. Human Amniotic Fluid Promotes Retinol Pigmented Epithelial Cells Transdifferentiotion into Rod photoreceptors and Retinal Gonglion Cells. Bagheri A, Soheili ZS, Ahmadieh H, Darvishalipour Sh, Samie Sh , Rezaei-kanavi M, Dizaji A, The Influence of Different Concentrotions of Bevocizumob on Matrix Methalloproteinase r-(MMPr-) Production and Activity in Humon Retinol Pigment Epithelial Cell Culture. Nourinia R, Ahmadieh H, Soheili ZS, Akrami H, Rezaei-kanavi M, Samiei Sh, Knockdown of the Placental Growth factor (PIGF) Gene Inhibits Laserinduced Choroidal Neovascularization in a Murine Model. Paylakhi H, Mehrabian M, Yazdani Sh, Rezaei-Kanavi M, Soheili ZS, Elahi E, FOXC, may regulate MYOC Expression in the Trobecular Meshwork. Davari M, Shoheili Zs, Ahmadieh H, Sanie-Jahromi F, Ghoderi Sh Samie Sh, Pakravesh J, Examination of the Effect of Amniotic Fluid on Transdiffferentiation and Dedifferentiation of Retinal Pigment Epithelial Cells. 11th EURETINA Congress, May 2011, London, England Zahra-Soheila Soheili, Abouzar Bagheri, Hamid Ahmadieh, Shahram Samiei, Shamila D. Alipour, Mozhgan RezaeiKanavi (Oral Presentation) Anti-CTGF affects MMP-2 quantity and activity in human retinal pigment epithelial (RPE) cell culture. Zahra-Soheila Soheili, Abouzar Bagheri, Hamid Ahmadieh, Shahram Samiei, Shamila D. Alipour, Mozhgan RezaeiKanavi Bevacizumab in different concentrations affects MMP-2 production and activity in human retinal pigment epithelial cell culture. Hamid Ahmadieh, Abouzar Bagheri, Zahra-Soheila Soheili, Shahram Samiei, Shamila D. Alipour, Mozhgan RezaeiKanavi Bevacizumab varies transcription of Cathepsin D and α-smooth muscle actin in human retinal pigment epithelial (RPE) cells. Zahra-Soheila Soheili, Abouzar Bagheri, Hamid Ahmadieh, Shahram Samiei, Shamila D. Alipour, Mozhgan RezaeiKanavi Identification of Ikaros gene expression in human retinal pigment epithelial cells. Zahra-Soheila Soheili, Fatemeh NazemRoaya, Abdolkhalegh Deezagi, Abouzar Bagheri, Hamid Ahmadieh, Shamila D. Alipour, Mozhgan RezaeiKanavi Human Retinal Pigment Epithelial Cell (RPE) Culture on polyHEMA coated Culture Substrates. Zahra-Soheila Soheili, Abouzar Bagheri, Hamid Ahmadieh, Shahram Samiei, Shamila D. Alipour, Mozhgan Rezaei-Kanavi (Oral Presentation) CTGF neutralizing antibody influences MMP-9 activity and quantity in human RPE cell culture. Zahra-Soheila Soheili, Abouzar Bagheri, Hamid Ahmadieh, Shahram Samiei, Shamila D. Alipour, Mozhgan RezaeiKanavi The effect of Bevacizumab on MMP-9 production in human retinal pigment epithelial cell culture. Zahra-Soheila Soheili, Abouzar Bagheri, Hamid Ahmadieh, Shahram Samiei, Shamila D. Alipour, Mozhgan RezaeiKanav The Effect of Bevacizumab on VEGFA and VEGFR-1 Gene Transcriptions in Human RPE Cell Culture. Research and Innovation in Ophthalmology, 1-2 March 2012, Farabi Eye Hospital, Tehran Iran Zahra soheila Soheili, Sanie-Jahromi F, Ahmadieh H, Davari M, Ghaderi Sh, Rezaei-Kanavi M, Samie Sh, Dizaji A, Pakravesh (oral presentation, invited speaker) Evaluating the effect of amniotic fluid on growth, transdifferentiation and dedifferentiation of RPE cells. World Ophthalmology Congress 2012 Feb., Abu Dhabi, United Arab Emirates Fatemeh Nazem-Roaya, Zahra-Soheila Soheili, Hamid Ahmadieh, Abdolkhalegh Deezagi, Abouzar Bagheri, Shamila D. Alipour, Razeih Heidari. Human Retinal Pigment Epithelial Cell Culture on polyHEMA Coated Culture Substrates and The Pattern of Specific Gene Expression. Razieh Heidari, Zahra-Soheila Soheili, Hamid Ahmadieh, Fatemeh Nazem-Roaya, Abdolkhalegh Deezagi, Shamila D. Alipour, Mozhgan Rezaei-Kanavi. Culture of human retinal pigment epithelial cells in 3D-alginate polymer and investigation of viability and gene expression. Razieh Heidari, Zahra-Soheila Soheili, Hamid Ahmadieh, Fatemeh Nazem-Roaya, Abdolkhalegh Deezagi, Shamila D. Alipour, Mozhgan Rezaei-Kanavi Investigation of cell proliferation and cell death in Human Retinal Pigment Epithelial cells cultured in 3D- alginate matrix. Fatemeh Nazem-Roaya, Zahra-Soheila Soheili, Hamid Ahmadieh, Abdolkhalegh Deezagi, Abouzar Bagheri, Shamila D. Alipour, Razeih Heidari. Culture of Human Retinal Pigment Epithelial Cells) on polyHEMA Coated Culture Substrates and Evaluation of the Rate of Cell Proliferation and Cell Death. 12th Euretina Congress, Sep 2012, Milan ITALY Zahra-Soheila Soheili, Abouzar Bagheri, Hamid Ahmadieh, Shahram Samiei, Shamila D. Alipour, Mozhgan RezaeiKanav Effect of Bevacizumab/Anti-CTGF Neutralizing Antibody on the Production and Activity of MMP-2 in Human RPE cells. Fatemeh Nazem-Roaya, Zahra-Soheila Soheili, Hamid Ahmadieh, Abdolkhalegh Deezagi, Abouzar Bagheri Expression of NESTIN, PAX6 and CHX10 Proteins in RPE Cells Cultured on PolyHEMA Coated Culture Substrate. Razieh Heidari, Zahra-Soheila Soheili, Hamid Ahmadieh, Fatemeh Nazem-Roaya, Abdolkhalegh Deezagi, Shamila D. Alipour, Mozhgan Rezaei-Kanavi Persistance of Human Retinal Pigment Epithelial Cells Integrity in 3D-Alginate Polymer. Fatemeh Nazem-Roaya, Zahra-Soheila Soheili, Hamid Ahmadieh, Abdolkhalegh Deezagi, Abouzar Bagheri RPE Cells Generate Giant Colonies on Polyhema and Maintain Their Characteristic Expression of RPE65 and Cytokeratin8/18 Proteins. Razieh Heidari, Zahra-Soheila Soheili, Hamid Ahmadieh, Fatemeh Nazem-Roaya, Abdolkhalegh Deezagi, Shamila D. Alipour, Mozhgan Rezaei-Kanavi Expression of Nestin Gene in Human Retinal Pigment Epithelial Cells Cultured in 3D-Alginate Polymer. Zahra-Soheila Soheili, Abouzar Bagheri, Hamid Ahmadieh, Shahram Samiei, Shamila D. Alipour, Mozhgan RezaeiKanav Effect of Bevacizumab and Anti-CTGF Neutralizing Antibody on the Gene expression of CTGF in Human RPE cells. Abouzar Bagheri, Zahra-Soheila Soheili, Hamid Ahmadieh, Shahram Samiei, Shamila D. Alipour, Mozhgan RezaeiKanav Effect of Bevacizumab and Anti-CTGF Neutralizing Antibody on the Gene expression of VEGF-A, VEGFR-1 and Cathepsin D in Human RPE cells. IRAVO 2012, 8-9 March, Farabi Hospital, Tehran, Iran Bagheri A, Soheili Z.S., Ahmadieh H, Samiei S. Rezaei-Kanavi M. Effects of Bevacizumab and an Anti-CTGF neutralizing antibody on the Angiogenic and Fibrotic factors in the Human RPE cell cultures. Feyzi S., Soheili Z.S., Bagheri A., Ahmadieh H., Samiei S. Effect of amniotic fluid on in vitro culture of human corneal endothelial cells. Fahimeh Javidi, Zahra-Soheila Soheili, Shahram Samiei, Hamid Ahmadieh. Amniotic fluid growth inducing effects on retinal primitive cells’ population. Fahimeh Javidi, Zahra-Soheila Soheili, Shahram Samiei, Hamid Ahmadieh. A spontaneously arising RPE cell line from human RPE cell primary culture. Mina Rafiei, Zahra-Soheila Soheili, Nematollah Arshdi, Shahram Samiei, Hamid Ahmadieh. Application of Surface-modified Gold Nanoparticles Functionalized by Amino acids as a substrate to culture for Retinal Pigment Epithelial (RPE) Cells. Ensieh Darbari, Zahra-Soheila Soheili, Habib Rezanejad, Shahram Samiei, Hamid Ahmadieh. Regeneration of Retinal Primitive Cells and Neural Cells Trough SOX2 Over Expression in RPE Cell Cultures. Habib Rezanejad, Zahra-Soheila Soheili, Farhang Haddad, Shahram Samiei, Maryam M. Matin, Ali Manafi, Hamid Ahmadieh. In vitro differentiation of human adipose tissue- derived stem cells into photoreceptors and RPE cells by transduction of PAX6 (5a). Marzieh Habibi, Zahra-Soheila Soheili, Nematollah Arshdi, Shahram Samiei, Hamid Ahmadieh. Capped- Gold Nanoparticles as Cultures Scafold for HumanRPE Cells. Seyed Ahmad Mohammadi, Zahra Soheila Soheili, shahram samiei, Abdolkhaleg Deezagi, Hamid Ahmadieh. GRP78 knockdown in Retinal pigment epithelium (RPE) cells and its effects on inflammatory factors expression. Azam Mohammadian, Zahra- Soheila Soheili, Razieh Jalal, Shahram Samiei, Hamid Ahmadieh, Abouzar Bagheri. Effect of Passage Number on Melanogenic Factors in Human RPE Cells. Azam Mohammadian, Zahra- Soheila Soheili, Razieh Jalal, Shahram Samiei, Hamid Ahmadieh, Abouzar Bagheri. Melanogenic Factors Gene Expression in Human Neonatal RPE Cells in Comparison to Human Adult RPE cells; an in Vitro Study. Sepehr Feizi, Zahra-Soheila Soheili, Sahar Balagholi, Azam Mohammadian, Hamid Ahmadieh, Shahram Samiei, Mozhgan RezaeiKanavi, Narsis Daftarian. Effect of Amniotic Fluid on in Vitro Culture of Human Corneal Endothelial Cells. 13th Euretina Congress, Sep 2013-10-13, Hamburg Germany Z. Soheili, M. Habibi M. Rafiei N. Arshdi S. Samiei H. Ahmadieh, Application of surface-modified gold nanoparticles functionalized by amino acids as culture scaffold for human RPE Z.Soheili, H. Rezanejad F. Haddad S. Samiei M. Matin In vitro differentiation of human adipose tissue-derived stem cells into photoreceptors and RPE cells by transduction of PAX6 (5a). Z.Soheili, E. Darbari, H. Rezanejad, S. Samiei, H. Ahmadieh , Regeneration of retinal primitive cells and retinal neural cells through SOX2 over-expression in RPE cultures. S. Samiee, S. Mohammadi, Z. Soheili, A. Deezagi, H. Ahmadieh GRP78 knockdown in retinal pigment epithelium (RPE) cells and its effects on inflammatory factors expression. H. Ahmadieh, F. Javidi, Z. Soheili, S. Samiei. A spontaneously arising RPE cell line from human RPE cell primary cultures. Azam Mohammadian, Zahra- Soheila Soheili, Razieh Jalal, Shahram Samiei, Hamid Ahmadieh, Abouzar Bagheri Melanogenic Factors Gene Expression in Human Neonatal RPE Cells in Comparison to Human Adult RPE cells; an in Vitro Study. Fahimeh Javidi, Zahra-Soheila Soheili, Shahram Samiei, Hamid Ahmadieh. Amniotic fluid growth inducing effects on retinal primitive cells’ population. IRAVO; 2013, 7-8- March, Razi Convention Centre, Iran Sepehr Feizi, Zahra-Soheila Soheili, Sahar Balagholi, Azam Mohammadian, Hamid Ahmadieh, Shahram Samiei, Mozhgan Rezaei-Kanavi, Narsis Daftarian. Effect of Amniotic Fluid on in Vitro Culture of Human Corneal Endothelial Cells. Ensieh Darbari, Zahra-Soheila Soheili, Habib Rezanejad, Shahram Samiei, Hamid Ahmadieh. Regeneration of Retinal Primitive Cells and Neural Cells by Direct Reprogramming of RPE Cells Trough SOX2 over Expression. Habib Rezanejad, Zahra-Soheila Soheili, Farhang Haddad, Shahram Samiei, Maryam M. Matin, Ali Manafi, Hamid Ahmadieh. In Vitro Differentiation of Human Adipose Tissue- Derived Stem Cells into Photoreceptors and RPE Cells by Transduction of PAX6 (5a). Abouzar Bagheri, Zahra-Soheila Soheili, Hamid Ahmadieh, Shahram Samiei, Shamila D. Alipour, Azam Mohammadian, Sahar Balagholi. Effects of Bevacizumab and an Anti-CTGF Neutralizing Antibody on the Angiogenic and Fibrotic Factors in the Human RPE Cell Cultures. Marzieh Habibi, Zahra-Soheila Soheili, Nematollah Arshdi, Hamid Ahmadieh. Application of Surface-Modified Gold Nanoparticles Functionalized by Amino Acids as a Substrate to Culture for Retinal Pigment Epithelial (RPE) Cells. Fahimeh Javidi Azad, Fatemeh Sanie Jahromi, Zahra-Soheila Soheili, Shahram Samiei, Hamid Ahmadieh. A Spontaneously Arising RPE Cell Line from Human RPE Cell PrimaryCulture. Fahimeh Javidi Azad, Zahra-Soheila Soheili, Shahram Samiei, Hamid Ahmadieh Amniotic Membrane: A Convenient Scaffold for RPE Cell Culture. . Fahimeh Javidi Azad, Zahra-Soheila Soheili, Shahram Samiei, Hamid Ahmadieh. Amniotic Fluid Growth Inducing Effects on Retinal Primitive Cells’ Population. Seyed Ahmad Mohammadi, Zahra Soheila Soheili, shahram samiei, Abdolkhaleg Deezagi, Hamid Ahmadieh. GRP78 Knockdown in Retinal Pigment Epithelium(RPE) Cells and Its Effects on Inflammatory Factors Expression. Azam Mohammadian, Zahra- Soheila Soheili, Razieh Jalal, Shahram Samiei, Hamid Ahmadieh, Abouzar Bagheri. Effect of Passage Number on Melanogenic Factors in Human RPE Cells. . Azam Mohammadian, Zahra- Soheila Soheili, Razieh Jalal, Shahram Samiei, Hamid Ahmadieh, Abouzar Bagheri. Melanogenic Factors Gene Expression in Human Neonatal RPE Cells in Comparison to Human Adult RPE cells; An in Vitro Study Mina Rafiei, Zahra-Soheila Soheili, DR Arshadi, Shahram Samiei, Hamid Ahmadieh. Capped- Gold Nanoparticles as Culture Scaffold for Human RPE Cells. IRAVO; 2014, 13th February, Razi Convention Center, Iran Azade Etemadzade, Razie Ezati, Zahra-soheila Soheili, Hamid Ahmadieh, Shahram Samiei. Construction of AAVharboring hSOX2 gene to evaluate SOX2 over-expression in adult human RPE derived cells Razieh Ezzati, Azadeh Etemadzadeh, Zahra-Soheila soheili, Shahram Samiei, Hamid Ahmadieh. Transfection of human newborn RPE cells by SOX2 through pAAV-MCS viral vector. Maliheh Davari, Zahra-Soheila Soheili, Hamid Ahmadieh, Sharam Samiei, Ehsan Ranaei Pirmardan, Mozhgan Rezaei-Kanavi. Construction of Recombinant Adeno-Associated Virus-based Vectors bearing miR-183 Cluster Genes. Amir hossein Mansoori, Samira Kheytan, Zahra-soheila soheili, Hamid Ahmadieh, Shahram Samiei, Shamila Darvish Alipour. Construction of AAV particles harboring hGRP78 sequence and transduction of hRPE culture. Ehsan Ranaei Pirmardan, Zahra Soheila Soheili, Hamid Ahmadieh, Seyed Javad Mowla, Mozhgan Rezaei Kanavi, Shahram Samiei, Maliheh Davari, Shima Ghaderi, Razieh Ezzati, Azadeh Etemadzadeh. Production of Recombinant Adeno-Associated Virus (Raav), Harboring Pax6-IRES/EGFP Construct, for Mouse Retinal Infection. Shima Ghaderi, Samira Kheitan, Zahra-Soheila Soheili, Shahin Ahmadian, Hamid Ahmadieh, Shahram Samiei. Production of Recombinant Adeno-Associated Viruses (rAAV) Carrying Human Grp78 (Glucose-regulated protein, 78 kDa) Transgene Via AAV-Helper Free System. IRAVO; 2015, March 5-6, Razi Convention Centre, Iran AzadehEtemadzadeh, Razie Ezati, Zahra-Soheila Soheili, Hamid Ahmadieh, Shahram Samiei Ehsan Ranaei Pirmardan. Evaluation of AAV-Mediated Sox2 Overexpression on Adult Human RPE. Shima Ghaderi, Zahra-Soheila Soheili, Shahin Ahmadian, Hamid Ahmadieh, Shahram Samiei. Simple and Inexpensive purification and concentration of recombinant AAv forefront vectors in human gene therapy. Amir Hossein Mansouri, Samira Kheytan, Zahra-Soheila Soheili, Hamid Ahmadieh, Shahram Samiei, Shima Ghaderi, Shamila Darvishalipour. Studying GRP-78 overexpression in cultured adult human RPE cells; effects on expression of the inflammatory factors. Ehsan Ranaei Pirmardan, Zahra-Soheila Soheili, Hamid Ahmadieh, Seyed Javad Mowla, Mozhgan Rezaei Kanavi, Shahram Samiei, Razieh Ezzati, Maliheh Davari, Shima Ghaderi, Narsis Daftarian. In Vivo expression of EGFP in mouse retia mediated by AAV. Razieh Ezzati, Zahra-Soheila soheili, Ehsan Ranaei Pirmardan, Shahram Samiei, Hamid Ahmadieh. Sox2 Overexpression stimulated human newborn RPE cells to dedifferentiate towards retinal progenitor cells. Hoda Shams-Najafabadi, Zahra Soheila Soheili, Shahram Samiei. Proliferation and differentiation of human RPE cells cultured on alginate-gelatin substrate. Fahimeh Zakeri, Mehsi Sadeghi, Zahra Soheila Soheili. Designing, generation and characterization of AAV-sFLTo1 gene therapy for neo-vascular based ocular disease. 16th Euretina Congress- Copenhagen 2016 Z. Soheili E. RanaeiPirmardan S. Samiei S. Mowla R. Ezati M. Naseri Characterization of a spontaneously generated murine retinal pigmented epithelium cell line; a model for in vitro experiments, S. Samiei, M. Davari Z. Soheili E. Ranaei-Pirmardan Evaluation of miR-183 cluster over expression effects on retinal pigment epithelial (RPE) cells. Z. Soheili, M. Massoumi S. Samiei M. Davari E. RanaeiPirmardan S. Ghaderi Evaluation of miR-30d, miR-181a and miR-199a-5p and GRP78 expression in human newborn and adult RPE cells in culture. Z. Soheili S. Mowla S. Samiei M. Naseri H. Ahmadieh Iran, E. RanaeiPirmardan Generation of an experimental mouse model of glaucoma by n-methyl d-aspartic acid. H.Ahmadieh, S. Ghaderi S. Ahmadian Z. Soheili S. Samiei . Overexpression of unfolded protein response (UPR) master regulator GRP78/BiP in human retinal pigment epithelial (RPE) cells. S. Samiee, F. Zakeri M. Sadehi Z. Soheili S. Samiei E. RanaeiPirmardan E. Rezaei sFLT01 Chimeric protein sequence suggestion, tertiary structure prediction, expression of construct in host cells and in vitro anti-angiogenic functional analysis. S.Samiei, E. Rezaei M. Sadehi Z. Soheili. sFLT01 Engineering for ph-dependent binding to improve Its recycling and neutralization potency as a chimeric VEGF receptor. 16th Euretina Congress- Copenhagen 2016 Poster Z. Soheili, E. Ranaei Pirmardan S. Samiei S. Mowla R. Ezati M. Naseri Characterization of a spontaneously generated murine retinal pigmented epithelium cell line; a model for in vitro experiments. S. Samiei, M. Davari Z. Soheili E. Ranaei-Pirmardan Evaluation of miR-183 cluster over expression effects on retinal pigment epithelial (RPE) cells H. Ahmadieh, E. RanaeiPirmardan Z. Soheili S. Mowla S. Samiei M. Naseri Generation of an experimental mouse model of glaucoma by n-methyl d-aspartic acid H. Ahmadieh, S. Ghaderi S. Ahmadian Z. Soheili S. Samiei Overexpression of unfolded protein response (UPR) master regulator GRP78/BiP in human retinal pigment epithelial (RPE) cells S. Samiei, E. Rezaei M. Sadehi Z. Soheili sFLT01 Engineering for ph-dependent binding to improve Its recycling and neutralization potency as a chimeric VEGF receptor Z. Soheili, M. Massoumi S. Samiei M. Davari E. RanaeiPirmardan S. Ghaderi Evaluation of miR-30d, miR-181a and miR-199a-5p and GRP78 expression in human newborn and adult RPE cells in culture N. Daftarian, t. Motevasseli M. Rezaeikanavi A. Bagheri S. Hosseini H. Ahmadieh Z. Soheili Ocular safety of intravitreal anti connective tissue growth factor neutralizing antibody 17th Euretina Congress- Barcelona 2017 Oral, S. Samiei, M. Davari Z. Soheili E. Ranaei Pirmardan Overexpression of miR-183/-96/-182 triggers neuronal cell fate in human retinal pigment epithelial cells in culture Poster, Z. Soheili, E. Ranaei Pirmardan H. Ahmadieh S. Samiei In vivo evaluation of Pax6 overexpression in transformation of murine retinal differentiated cells to retinal progenitor cells International Congress on Biomedicine, 18-21 Dec. 2017, Tehran, Iran Fatemeh Nafian, Mohammad Javad, Shahin Yazdani, Zahra Soheila Soheili, RNY12 peptidomimetic increases SH-SY5Y Neuronal Survival Comparable to BDNF 8th Iranian Ophthalmology and Eye Science Research Conference, April 2018 Hamid Latifi-navid - Zahra-Soheila Soheili - Mehdi Sadeghi - Shahram Samiei Design and structurally analysis of sFLT01-based novel tri-specific molecule with antiangiogenic activity. Samira Kheitan - Zahra-Soheila Soheili - Zarrin Minuchehr Interplay between ER Stress and Inflammation in AMD Bahareh Safdari - Mozhgan Rezaei Kanavi - Iman Salahshourifar - Zahra-Soheila Soheili Genes expression of NOGO-A and its receptors in amniotic fluid treated human RPE cells Edris Rezaei - Mehdi Sadeghi - Zahra-soheila soheili - sepideh taghizadeh Designing msFLT1.0 protein with use of Rational Protein engineering: Improves the potential of VEGF neutralization for inhibiting Neovascular Age-Related Macular Degeneration 2nd International Congress on Biomedicine, ICB, 24-27 Dec. 2018 H Latifi-navid, ZS soheili, M Sadeghi, S Samiei, E Ranaei Pirmardan, H Shams Najafabadi Development of ex vivo adult retinal explant organotypic tissue culture system for anti-angiogenic drug evaluation H Shams Najafabadi, ZS Soheili, S Samiei, E Ranaei Pirmardan, A Kashanian, R Salmanipour Generation of hek-girk stable cell line as an applied model for optogenetic study H Latifi-navid, ZS soheili, M Sadeghi, S Samiei, E Ranaei Pirmardan, S Arab Sfn0011: a sflt01-based novel tri-specific molecule with antiangiogenic activity H Parsamehr, ZS Soheili, Ehsan Ranaei The effect of sflt01 gene expression on cell proliferation and migration of bladder cancer cell line; 5637 The 9 th Annual Meeting of the Iranian Research Association for Vision and ophthalmology, Razi Convention Center, April 18-19, 2019 Hoda Shams Najafabadi, Zahra-Soheila Soheili, Hamid ahmadieh, Sharam Samiei, Ehsan Ranaei Pirmardan, Amirhossein Mahmoodi Neural differentiation of mouse retinal pigment epithelial cells by expression of optogenetic construct Hoda Shams Najafabadi, Zahra-Soheila Soheili, Mehdi Sadeghi, Sharam Samiei, Ehsan Ranaei Pirmardan, Hamid Ahmadieh, Amirhossein Mahmoodi Expression of Opto-mGluR6 as a new generation optogenetic tool in HEK-GIRK stable cell line Hoda Shams Najafabadi, Zahra-Soheila Soheili, Hamid ahmadieh, Sharam Samiei, Ehsan Ranaei Pirmardan Neural Differentiation of Human Retinal Pigment Epithelial Cells on Alginate/Gelatin Substrate Hoda Shams Najafabadi, Zahra-Soheila Soheili, Sharam Samiei, Ehsan Ranaei Pirmardan, Ali Kashanian, Reza Salmanipour, Hamid Ahmadieh Generation of HEK-GIRK stable cell line as an applied model for optogenetic study Zeynab Hosseinpoor, Zahra-Soheila Soheili, Maliheh Davari, Hamid Latifi-Navid, Shahram Samie In silico identification of IRS1 related genes and proteins involved in Diabetic Retinopathy Maliheh Davari, Zahra-Soheila Soheili, Shahram Samiei, Ehsan Ranaei Pirmardan Designing a synchronous expression cassette for optimization of microRNA overexpression Hamid Latifi-navid, Zahra-Soheila Soheili, Shahram Samiei, Ehsan Ranaei Pirmardan, Sepideh Taghizadeh, Shamila Darvishalipoor A comprehensive study of signaling pathways that involve in angiogenesis and exploring crosstalk between angiogenesis, epithelial-mesenchymal transition and inflammation in age related macular degeneration Hamid Latifi-navid, Zahra-Soheila Soheili, Mehdi Sadeghi, Shahram Samiei, Ehsan Ranaei Pirmardan, Sepideh Taghizadeh, Seyed Shahriar Arab, Fahimeh Zakeri Designing, construction and functional analysis of SFN0011 as a possible next generation antiangiogenic molecule. Sepideh Taghizadeh, Zahra-Soheila Soheili, Shahram Samiei, Ehsan Ranaei Pirmardan, Hamid Latifi-Navid A network analysis of possible intersection between angiogenic signaling pathways, metabolic symbiosis and endothelial cell metabolism in age related macular degeneration. International Conference on Cancer Research 2019, Website: www.CancerConf.org, June 10-11, London, UK Hamid Latifi-Navid, Sepideh Taghizadeh, Zahra-Soheila Soheili, Shahram Samiei, Ehsan Ranaie Pirmardan A Comprehensive Study of Possible Crosstalk between Angiogenic and Metabolic Signaling Pathways in Cancer 4th International and 16th Iranian Genetics Congress ISC: 99200-68682, IRAN/ITALY Sep30-Oct2 Borhan Baboli, Zahra-Soheila Soheili, Shahram Samiei, Ehsan Ranaei Pirmardan Knockdown of GRP78 gene expression by over ex¬pression of miR-181a in human bladder cancer cell line; 5637 Hamid Latifi-navid, Zahra-Soheila Soheili, Mehdi Sad¬eghi, Shahram Samiei, Ehsan Ranaei Pirmardan, Sepideh Taghizadeh, Seyed shahriar Arab, Fahimeh Zakeri Designing, construction and functional analysis of SFN0011 as a possible next generation antiangiogenic mol¬ecule. 16th National Congress of Biochemistry & 7th International Congress of Biochemistry & Molecular Biology 9-12 November 2020, Tehran, Iran Sepideh Taghizadeh, Zahra-Soheila Soheili, Shahram Samiei, Ali Kashanian, Hoda Shams Najafabadi Effects of sFLT01 overexpression on angiogenesis and migration of DU145 prostate cancer cell line Hoda Shams Najafabadi, Zahra-soheila Soheili, Hamid Ahmadieh, Shahram Samiee, Mehdi Sadeghi, Mohammad Ismail Zibaii, Ehsan Ranaei Pirmardan and Sepideh Taghizadeh Neural Differentiation of Retinal Pigment Epithelial Cells and Mesenchymal Stem Cells by Optogenetic Stimulation Hamid Latifi-navid, Zahra-Soheila Soheili, Mehdi Sadeghi, Shahram Samiei, Ehsan Ranaei Pirmardan, Sepideh Taghizadeh, Seyed shahriar Arab, Saman Tajbakhsh, Fahimeh Zakeri SFN0011: A new developed next-generation anti-angiogenic molecule. Hoda Shams Najafabadi, Zahra-Soheila Soheili, Sharam Samiei, Hamid Gholami Pourbadie, Mohammad Ismail Zibaii Expression and function of engineered red Opto-mGluR6 as an optogenetic neural inducer in HEK-GIRK cell line Narges Zolfaghari, Zahra-Soheila Soheili, Maliheh Davari, Shahram Samiei Cloning of mmu-miR-96 into pAAV-MCS vector to pursue for its role in diabetic retinopathy Somayeh piroozmand, Zahra-Soheila Soheili, Saman Hosseinkhani, Shahram Samiee Physicochemical characterization of MiRGD peptide and sFLT01 gene nano-carrier IRAVO 17-19 FEB, 2021, TEHRAN, IRAN Narges Zolfaghari, Zahra-Soheila Soheili, Maliheh Davari, Shahram Samiei mmu-miR-96 Expression in mRPE Cell Line Under High Glucose Condition Zeynab Hosseinpoor, Zahra-Soheila Soheili, Maliheh Davari, Shahram Samie, Hamid Ahmadieh Effects of miR-96 overexpression on Pigment epithelium-derived factor (PEDF) expression in hRPE cells Zeynab Hosseinpoor, Zahra-Soheila Soheili, Maliheh Davari, Shahram Samie, Hamid Ahmadieh MicroRNA-96 impairs insulin signaling pathway by inhibiting IRS2 associated signaling molecules Mahshad Karimifard, Zahra-Soheila Soheili, Maliheh Davari, Hamid Latifi Navid, Shahram Samiei miR-96 overexpression in hRPE cells, surveying the effects on the target genes that are involved in proliferation Hoda Shams Najafabadi, Zahra-Soheila Soheili, Mohammad Ismail Zibaii, Shahram Samiee, Hamid Ahmadieh, Mehdi Sadeghi, Ehsan Ranaei Pirmardan, Sepideh Taghizadeh Optogenetic Stimulation Promotes Proliferation and Neuroretinal differentiation of Retinal Pigment Epithelial Cells and Mesenchymal Stem Cells Hoda Shams Najafabadi, Zahra-Soheila Soheili, Mehdi Sadeghi, Hamid Ahmadieh, Hamid Gholami Pourbadie, Amir-Hossein Mahmoudi, Sharam Samiei, Mohammad Ismail Zibaii Engineered Red Opto-mGluR6 Variants as Red-shifted Optogenetics Tools to Induce Action Potential in HEK-GIRK Cells Hamid Latifi Navid, Zahra-Soheila Soheili, Mehdi Sadeghi, Shahram Samiei, Ehsan Ranaei Pirmardan, Sepideh Taghizadeh, Seyed Shahriar Arab, Saman Tajbakhsh, Fahimeh Zakeri SFN0011: A Novel Potent Inhibitor as a Next-generation Anti-angiogenic Molecule Hamid Latifi-Navid, Zahra-Soheila Soheili, Shahram Samiei, Mehdi Sadeghi Identification of Key Residues in SFN0011 Protein Structure Through Network Centrality Analysis and Computational Machine Learning Approaches. Somayeh Piroozmand, Zahra-Soheila Soheili, Saman Hosseinkhani, Shahram Samiee Characterization of MiRGD peptide nanocarrier for sFLT01 gene delivery to the retinal pigment epithelium cells