معرفی - دکتر حق بین - پژوهشگاه ملی مهندسی ژنتیک و زیست فناوری

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مدارج علمی

دکتری شیمی زیست آلی، دانشگاه اوتاگو، نیوزلند، ۱۹۹۸
پسادکتری تثبیت آنزیم، مهندسی شیمی، ۲۰۰۷
استاد مدعو دانشگاه واترلو، کانادا، ۲۰۰۸، نوامبر ۲۰۱۲
استاد مدعو دانشگاه پاریس-سود/ساکلی، اکتبر ۲۰۱۸، اکتبر ۲۰۱۹
استاد مدعو دانشگاه کریستین-آلبرشت، کیل، آلمان، سپتامبر تا دسامبر ۲۰۲۱
همکاری علمی 5 ساله با مرکز تحقیقات محیط زیست هلم هولتز، لایبزیک آلمان 2013 الی 2017

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کمال‌الدین حق‌بین

استاد بیوشیمی آلی، آنزیمولوژیست

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متابولیت‌های ثانویه گیاهی

آنزیم‌های اکسیدکننده ترکیبات فنلی

من کمال‌الدین حق‌بین، استاد بیوشیمی آلی و آنزیمولوژیست در پژوهشگاه ملی مهندسی ژنتیک و زیست‌فناوری هستم. کارشناسی ارشد خود را در رشته شیمی آلی از دانشگاه فردوسی مشهد (ایران) و دکترای تخصصی خود را در رشته بیوشیمی آلی از دانشگاه اوتاگو (نیوزیلند) دریافت کرده‌ام. دوره فرصت مطالعاتی و پسادکتری را در دانشگاه واترلو (کانادا) بوده ام و علاوه بر همکاری مستمر با مراکز دانشگاهی و تحقیقاتی ایران، در مراکز تحقیقاتی و دانشگاهی آلمان، کانادا، و فرانسه حضور داشته و با محققان ایرانی و غیر ایرانی همکاری داشته ام. من علاقه‌مند به مطالعه آنزیم‌ها بویژه فنلازها، شیمی ترکیبات آزو و فنلی و مطالعه بیوسنتز و تولید مشتقات طبیعی فنل به کمک فناوری کشت سلولی گیاهی با استفاده از روش های مختلف اسپکتروسکوپی، آنزیمولوژی، و بایوآنالایتیکال هستم. در طول دوران حرفه‌ای خود، علاوه بر تجربیات متعددی در زمینه تدریس و تحقیق، سمت‌های اجرائی مختلفی را نیز در دانشگاه‌ها و موسسات پژوهشی داشته‌ام.

QUALIFICATIONS & AWARDS

CAREER HISTORY

POSITIONS & AFFILIATIONS

RESEARCH PROJECTS

PUBLICATIONS

BOOKS & PATENTS

NATIONAL PRESENTATIONS

INTERNATIONAL PRESENTATIONS

TEACHING & TUTORIALS

RESEARCH THESES

QUALIFICATIONS
BSc (Chemistry)	Mashhad University, Iran		1989
MSc (Organic Chemistry)	Mashhad University, Iran		1992
PhD (Bio-organic Chemistry)	Otago University, New Zealand		1998
Sabbatical Research	Chem Eng Dept. of Waterloo Un. Canada		2007-2008
Visiting Professor	Chem Eng Dept. of Waterloo Un. Canada		Nov. 2012
Visiting Professor	Plant Ecophysiol Dept, Paris-Sud Un.		Sep-Oct 2018
Visiting Professor	Plant Ecophysiol Dept, Paris-Saclay Un.		Sep-Oct 2019
Visiting Professor	Dept. Pharmaceutical Biology, Christian-Albrecht University, Kiel, Germany		Sep. to Dec. 2021


AWARDS
MSc scholarship	1989	The Ministry of Culture and Higher Education
PhD scholarship	1992	The Ministry of Culture and Higher Education
NSERC Grant (Canada)	2007	In collaboration with Professor R.L. Legge
DAAD Grant (Germany)	2012	In collaboration with Professor D. Schlosser
Paris-SUD Un. Grant	2018	In collaboration with Professor J. Ghashghaie
Paris-Saclay Un. Grant	2019	In coll. with Prof. J. Ghashghaie & Dr. Zoran G. Cerovic
DAAD Grant	2021	In collaboration with Professor C. Zidorn


WORKSHOPS

Career History
Jan. 1990 to Aug. 1991	Researcher (part-time)	Mashhad University, (Science branch of Jehad Daneshgahi)
Feb. 1990 to Feb. 1992	Teaching Assistant (part-time)	Mashhad University (Department of Chemistry)
Feb. 1990 to Feb. 1992	Teaching Fellowship (part-time)	Free University of Mashhad
May 1992 to Oct. 1993	Junior Lecturer (Full time)	Department of Chemistry, International University of Imam Khomeini
Feb. 1998 to July 1999	Assistant Professor (Full-time)	Department of Chemistry, International Un. of Imam Khomeini
Oct. 1999 up to now	Tenure Position as a Researcher and a Lecturer (Professor of Bioorganic Chemistry)	NRCGEB (now NIGEB)
Feb. 1992 up to now	Collaboration with other Iranian Universities as lecturer and research supervisor

Positions

2009 -20011	Head of Basic Sciences of Biotechnology Research Group (NIGEB)
2011 - 2013	Director of Evaluation, Budget, and Planning Office (NIGEB)
2012 - 2014	Head of Microbial Biotechnology Group (University of Science and Technology of Mazandaran)
2014 - 2018	Head of Plant Bioproducts Group (NIGEB)
2018 - 2020	Head of Agricultural Biotechnology Department (NIGEB)
2023 up to now	Manager of the International Office for Scientific Collaborations (NIGEB)

POSITIONS

2009 -20011	Head of Basic Sciences of Biotechnology Research Group (NIGEB)
2011 - 2013	Director of Evaluation, Budget, and Planning Office (NIGEB)
2012 - 2014	Head of Microbial Biotechnology Group (University of Science and Technology of Mazandaran)
2014 - 2018	Head of Plant Bioproducts Group (NIGEB)
2018 - 2020	Head of Agricultural Biotechnology Department (NIGEB)
2023 up to now	Manager of the International Office for Scientific Collaborations (NIGEB)

1-3 March 2016, NIGEB, Tehran, IRAN	Head of Scientific Committee of 1st Congress of Chemical Biotechnology

Research Projects
1	Primiphos methyl synthesis	Granted by the science branch of Jehad Daneshgahi-Mashhad University	1991
2	Synthesis of the novel heterocyclic system, pyrimido [4,5-d] [1,2,3] triazine	MSc thesis (Scholarship)	1992
3	Kinetic and spectroscopic studies on cresolase and catecholase activities of tyrosinase	PhD thesis (Scholarship)	1998
4	Comparative study on Laboratory Scale Production of Shikonin by Arnebia euchroma, Lithospermum officinale and Lithospermum erythrorhizon in suspension Culture.	NRCGEB	2003
5	Examining the effect of shikonin on Helicobacter Pilori growth and proliferation	Ministry of Culture and Higher Education	2004
6	Production and purification of cholesterol oxidase from Nocardia Erythropolis (rhodococcus erythropolis ATCC 4277) and proper assay of its activity	Ministry of Culture and Higher Education	2005
7	Examining the biotransformation of phenolic substrates to ortho-dihydroxy compounds by the trapped tyrosinase into the solid phase	NRCGEB	2005
8	Measuring phenolic substances in the drinking water underground resources of Tehran by enzymatic and chemical methods.	Organization for Protection of Environment	2007
9	New applications for diazo derivatives of catechol	Presidential Office for Supporting Researchers (INSF)	2008
10	Designing selective inhibitors for tyrosinase	NIGEB	2008
11	Novel Diazo Cross-linkers	Natural Sci. and Eng. Res. Council (NSERC) – Canada	2008
12	Surveying the Biochemical and Biophysical properties of the Arnebia euchroma Peroxidase	NIGEB	2009
13	Studying the anti-inflammatory effect of shikonin on microgelial cells	NIGEB	2010
14	Purification, biochemical characterization and hemagglutinin activity of Agaricus bisporus Lectin	NIGEB	2010
15	Examining the organogenesis ability of the medicinal plant, Arnebia euchroma, callus	NIGEB	2011
16	Co-immobilization of tyrosinase and laccase in Cross-Linked Poly acrylamide using One Phase Binary Solutions as the reaction medium	German Academic Exchange Service (DAAD)	2012

Research Projects (continue)
17	Examination of phenol removal methods from drinking water resources	Organization for Protection of Environment	2012
18	Identifying the phenolic pollutants in the drinking water resources of Tehran	Organization for Protection of Environment	2012
19	Enzymatic production of L-dopa; pre-pilot research	the Iran National Science Foundation (INSF)	2015
20	Study of indirect regeneration of Arnebia pulchra	NIGEB	2015
21	Synthesis of a novel class of chromophoric cross-linkers	University of Waterloo, ON-Canada	2016
22	Comparative evaluation of the antioxidant capacity of the extracts of callus and natural root of Arnebia euchroma	NIGEB	2016
23	Synthesis and preparation of advanced nano and mesoporous xerogels for enzyme immobilization and pollutant adsorption	ICRP
24	Reviewing analytical methods for measuring the concentration of total aromatic compounds in water resources	Tehran Water and Waste waters management	2017
25	Comparative study on the production of phenolic metabolites in the callus of Alkanna frigida and its natural root	NIGEB	2018
26	Non-destructive fluorescence-based method for monitoring the development of phenolic compounds in the solid cell culture of medicinal plants	Joint Research with the University of Paris-SUD	2018-2019
27	Evaluation of capabilities of phenolic compounds of Onosma dasytrichum and Alkanna frigida for UVA absorption and tyrosinase inhibition	NIGEB	2019
28	Extraction of phenolic acids with polyphenolase inhibition and UVA extinction capabilities from Rosa damascene waste	INSF	2019
29	Controlled release of plant aroma from hydrogel	Ministry of Science and Technology	2020
30	The fate of alkaloids in the cell culture of two medicinal plants of Boraginaceae; Lithospermum officinale and Nonea caspica	DAAD + NIGEB	2021

Undergraduate Courses

Postgraduate Courses

1 - General Chemistry (I),

2 - General Chemistry (II),

3 - Analytical Chemistry,

4 - Organic Chemistry (I),

5 - Organic Chemistry (II),

6 - Organic Chemistry (III),

7 - Biochemistry (Basic),

8 - Environmental Chemistry,

9 - Principle of Organic Synthesis,

10 - Physical Organic Chemistry,

11 - Separation and Identification of Organic Compounds,

12 - Applications of Spectroscopic Methods

13 - Biochemistry (Advanced),

14 - Cellular Biophysics,

15 - Transport phenomena in living organisms,

16 - Biochemical and Biophysical Methods in Bioscience,

17 - Applied Enzymology

فعالیت های پژوهشی

Publications (1)
1	J. Org. Chem. 63, 4503-4505, (1998)	K. Haghbeen, Eng Wui Tan	Facile Synthesis of Catechol Azo Dyes
2	Anal. Biochem., 312 23-32 (2003)	K. Haghbeen*, Eng Wue Tan	Direct Spectrophotometric Assay of Mono-oxygenase and Oxidase Activities of Mushroom Tyrosinase in the Presence of Synthetic and Natural Substrates
3	Coll. Surf. B; Biointerfaces, 32, 137-143 (2003)	F. Karbassi, K. Haghbeen A. A. Saboury, B. Ranjbarb, A. A. Moosavi-Movahedia	Activity, Structural and Stability Changes of Mushroom Tyrosinase by Sodium Dodecyl Sulfate
4	BBRC. 314 925-930 (2004).	Shahrzad Shareefi Brojerdi, K. Haghbeen*,	Successful resonance Raman study of cresolase activity of mushroom tyrosinase
5	Biologia, Bratislava, 59/3: 317-324, (2004)	F. Karbassi, K. Haghbeen, A.A. Saboury	Calorimetric, spectrophotometric and circular dichroism studies on the impact of sodium dodecyl sulfate on the mushroom tyrosinase structure
6	Intl J Biol Macromol 34: 257–262, (2004)	A.A. Saboury, F. Karbassi, K. Haghbeen, B. Ranjbar, A.A. Moosavi-Movahedi,	Stability, structural and suicide inactivation changes of Mushroom tyrosinase after acetylation by N-acetyl imidazole
7	BBA - Gen. Subjects 1675/1-3 139-146, (2004)	K. Haghbeen*, Ali Akbar Saboury, Farhad Karbassi	Substrate share in the suicide inactivation of mushroom tyrosinase
8	Iranian J Biotechnol, 2(3) 189-194, (2004)	K. Haghbeen*, S. Shareefi Borojerdi, F. Rastgar	Purification of Tyrosinase from edible mushroom
9	Iranian Polymer J. 14(8) 729-734. (2005)	R. Agharafeie, K. Haghbeen*, M. Maghsudi	Polyacrylamide ability for protein immobilizing in one-phase binary-solvent systems
10	Coll. Surf. B: Biointerfaces 45 104–107. (2005)	N. Gheibi, A.A. Saboury, K. Haghbeen, A.A. Moosavi-Movahedi	Activity and structural changes of mushroom tyrosinase induced by n-alkyl sulfates
11	Intl J Biol Macromol. 36 305-309. (2005)	A. A. Saboury, M.S. Atri,M. H. Sanati, A.A. Moosavi-Movahedi, K. Haghbeen	Effects of calcium binding on the structure and stability of human growth hormone
12	J Enz Inh Med Chem. 20(4) 393-399. (2005)	N. Gheibi, A.A. Saboury, H. Mansuri-Torshizi, K. Haghbeen*, A.A. Moosavi	The inhibition effect of some n-alkyl dithiocarbamates on mushroom tyrosinase
13	Biologia Bratislava 20(4) 393-399 (2006)	K. Haghbeen*, V. Mozaffarian, F. Ghaffari	Lithospermum officinale callus produces shikalkin
14	J Enz Inh Med Chem. 21(6), 711-717 (2006)	A. A. Saboury, S. Zolghadri, K. Haghbeen, A. A. Moosavi-Movahedi	The inhibitory effect of benzenethiol on the cresolase and catecholase activities of mushroom tyrosinase.
15	J Biosci. 31 (3), 355-362 (2006).	N. Gheibi, A.A. Saboury, K. Haghbeen, A. A. Moosavi-Movahedi	The effect of some osmolytes on the activity and stability of mushroom tyrosinase
16	Bull Korean Chem Soc. 27 (5), 642-648 (2006)	N. Gheibi, A.A. Saboury, K. Haghbeen	Substrate Construes the Copper and Nickel Ions Impacts on the Mushroom Tyrosinase Activities
17	J Enz Inh Med Chem. 22(2), 239-246 (2007)	M. Alijanianzadeh, A.A. Saboury, H. Mansuri-Torshizi, K. Haghbeen,	The Inhibitory effect of some new synthesized xanthates on mushroom tyrosinase activities
18	Modern Genetics Journal, 2(2), 2007, 41-51.	Sheikhani R., Mousavi A., Jonoubi P., Haghbeen K.	Analysis of T1 generation of 5-enol pyruvylshikmate-3-phosphate synthase (EPSPS) transformed oil seed rape plants for glyphosate resistance

Publications (2)
19		Dyes and Pigments 77, 363-368 (2008)		S. Rouhani, S. Salimi, K. Haghbeen	Development of optical pH sensors based on derivatives of hydroxyazobenzene, and the extended linear dynamic range using a mixture of dyes
20		Spectrochimica Acta Part A 70(1) 1–6 (2008)		M. Shamsipur, B. Maddah, K. Haghbeen	Multiwavelength spectrophotometric determination of acidity constants of some azo dyes
21		Biotechnology, (ANSI) 7(2); 200-204 (2008)		K. Rahimi, K. Haghbeen, J. Marefatjo, F. Rastgar Jazii	Successful production of hairy root of Valeriana sisymbriifolium by Agrobacterium rhizogenes
22		Iranian Polymer J 17 (5), 2008, 345-352		N. Bahmanyar, K. Haghbeen*, A. Jamshidi, H. Mobedi	Studying the Structural Stability of Leuprolide acetate after Releasing from Lactide-co-Glycolide Copolymer by Different Spectroscopic Methods and HPTLC
23		J. Biol. Sci (ANSI), 8(3), 526-533, 2008		F. Saeid Nematpour, K. Haghbeen,	The Banana Pulp Polyphenol Oxidase Is a Tyrosinase
24		Chem. Engin. J. 2009, 150, 1-7.		K. Haghbeen, R.. L. Legge	Adsorption of Phenolic Compounds on Some Hybrid Xerogels
25		J. Enz. Inh. and Med. Chem. 24(5), 1076-1081 (2009)		N. Gheibi‌, A.A. Saboury‌, K. Haghbeen, F. Rajaei‌, A.A. Pahlevan‌	Dual effects of aliphatic carboxylic acids on cresolase and catecholase reactions of mushroom tyrosinase
26		Iranian J. of Biology, 22(2), 2009, 300-311		Alizadeh M., Sabouni F., Abbasi AH., Moghimi A., Haghbeen K.	Effects of shikonin, a component of Chinese herbal medicine, on activation and apoptosis of inflammated microglial cells in vitro
27	Spectrochimica Acta Part A 74 (2009) 691–694		K. Alizadeh, S. Seyyedi, K. Haghbeen		Solvatochromism and temperature effects on the electronic absorption spectra of some azo dyes
28	Interl J Biotechnol & Biochem (IJBB) 5, 4 (2009) 423—431.		J. Raheb, H. Esmaeil Lashgarian, Babak K. Haghbeen,		Identification of Novel Cholesterol Oxidase from Rhodococcus Erythropolis ATCC 4277
29	J. Food Biochem. 2010, 34(2) 308-327		K. haghbeen,*, F. Saeid Nematpour, M. Babaei,		Surveying allosteric cooperativity and cooperative inhibition in mushroom tyrosinase
30	J. Biomed. Biotech. 2011, doi:10.1155/2011/165852		K. Haghbeen,* S. Pourmolaei, M. J.Mareftjo, A.Mousavi, K. Akbari		Detailed Investigations on the Solid Cell Culture and Antimicrobial Activities of the Iranian Arnebia euchroma
31	Analytical Chemistry, 2011. 83(11), 4200-4205.		S.M. Moshtaghioun, K. Haghbeen		Direct Spectrophotometric Assay of Laccase Using Diazo Derivatives of Guaiacol,
32	Biotechnol Applied Biochem 2011, 58(6):456-63. doi: 10.1002/bab.42.		S. Farhadi, K. Haghbeen*, M.J. Marefatjo, M. Ghiyami Hoor		Anionic Peroxidase Production by Arnebia euchroma Callus
33	Intl Res J Applied & Basic Sci 2011, 392-397.pd		S. Bageri, F. Sanjarian, K. Haghbeen, M. Ali Ebrahimi		Establishment of cell suspension culture from onosma dasytrichum seed Callus culture
34	Biochem Eng J. 60, 2012, 99-105.		E. Jahangiria, R. Agharafeiea, K. Haghbeen*		Medium engineering to enhance mushroom tyrosinase stability
35	Iranian J. Biol, 2012 (1391), 25(3); 358-365.		Mirrazavi M., Sabouni F., Abbasi AH., Haghbeen K., Hajhosseini R. Nazem H.		The investigation of cytotoxic effects of standard shikonin and extraction shikonin from Arnebia euchroma on astrocytes

Publications (3)
36	Biochem Genet. 2012, 50(9-10):722-35. doi: 10.1007/s10528-012-9515-3	S. Babashpour, S. Aminzadeh, N. Farrokhi, A. Karkhane, K. Haghbeen	Characterization of a Chitinase (Chit62) from Serratia marcescens B4A and Its Efficacy as a Bioshield Against Plant Fungal Pathogens
37	Iranian Journal of Horticaltural Sciences, 43(4), 403-410, 2013	N. zaynali, M. Delshad, A. kashi, K. Haghbin	Effect of Water Stress on Yield and Fruit Quality of some Iranian Melons
38	J of Aquatic Ecology, 2013, 2(3), 1-13	Akbarzadeh A, Farahmand H, Mahjoubi F, Nematollahi M A, Haghbeen K, Kolangi Miandareh H.	Selection of suitable reference genes for real-time PCR studies of early developmental stages of sturgeons
39	AAPS PharmSciTech 2013, 14(1):160-7. doi: 10.1208/s12249-012-9899-8	M. Alemi, F. Sabouni, F. Sanjarian, K. Haghbeen, S. Ansari	Anti-inflammatory Effect of Seeds and Callus of Nigella sativa L. Extracts on Mix Glial Cells with Regard to Their Thymoquinone Content
40	progress in biological sciences 3(1) 2013, 53-59	A. Ahmadizadeh; F. Sanjarian; K. Haghbeen	Enzymatic detoxification of Don in transgenic plants via expression of Fusarium graminearum Tri101 gene
41	Marine and Freshwater Behaviour and Physiology, 2013, 45(5) 349–355,	A. Akbarzadeh, K. Haghbeen*, H. Farahmand,	The time course of L-gulono-gamma-lactone oxidase expression during the larval ontogeny
42	Acta Biochem Biophys Sinica, 2013 45:10 845-856.	S. Matroodi, M. Zamani, K. Haghbeen*	Physicochemical Study of a Novel Chimeric Chitinase with Enhanced Binding Ability
43	Biotechnol Appl Biochem. 2014 Mar-Apr;61(2):118-25. doi: 10.1002/bab.1140.	Mojallali L, Shahbani Zahiri H, Rajaei S, Akbari Noghabi K, Haghbeen K.	A novel ~34-kDa α-amylase from psychrotroph Exiguobacterium sp. SH3: production, purification, and characterization
44	Env Stu Persian Gulf, 2014, 1(2), 93-101)	A. Zaribafan, K. Haghbeen*	Spectrophotometric method for hydrogen peroxide determination through oxidation of organic dyes
45	Tetrahedron, (2015) 71(3), 436-444	H. Eshghi, F. Moeinpour, S. Rezaeian, M. Bakavoli, M. Teymouri, A. Rostami, K. Haghbeen	Nanomagnetic organic-inorganic hybrid (Fe@Si-Gu-Prs): a novel magnetically green catalyst for the synthesis of tetrahydropyridine derivatives at room temperature under solvent-free conditions
46	Iran J Basic Med Sci, 18(2) 2015, 122-129	N. Gheibi, N. Taherkhani, A. Ahmadi, K. Haghbeen, D. Ilghari	Characterization of inhibitory effects of the potential therapeutic inhibitors, benzoic acid and pyridine derivatives, on the monophenolase and diphenolase activities of tyrosinase
47	Iran J Biotech. 2015;13(4): e1058	P. Arghavani, K. Haghbeen*, A. Mousavi	Enhancement of Shikalkin Production in Arnebia euchroma Callus by a Fungal Elicitor, Rhizoctonia solani

Publications (4)
48	Canadian J. Chem. Eng. DOI: 10.1002/cjce.22341 2015, 93(12) 2214–2221	S. Hassani, A. Ghasemi, M. Fazli, K. Haghbeen,* R. L. Legge	Cation-assisted Adsorption of Chlorophenols by Nanoxerogels
49	J Applied Chem. 2015, 9 (33), 35-50 DOI: 10.22075/CHEM.2017.689	M. Shamsodin, M. Fazli, K. Haghbeen	Removal of Strontium (II) from aqueous solution by adsorption using Xerogel synthesized from TEOS: Batch and Fixed-bed Study
50	J Nanostructures, 5 (2015) 209-218	F. Bourumand Sarand, S. Hassani, M. Fazli, K. Haghbeen*	Nanoporous Xerogel for Adsorption of Pb²⁺ and Cd²⁺
51	J. Med. Plants and By-products, JMPB 2015, 4(2), 233-242	T.Ezati, M.J. Marefatjo, K. Haghbeen*,R. Ahmmadkhaniha	Successful indirect regeneration of Arnebia pulchra (Roemer and Schultes)
52	Iran. J. Chem. Chem. Eng. 34(4) 2015, 89-96	Darroudi, A.; Eshghi, H.; Rezaeian, S.; Chamsaz, M.; Bakavoli, M.; Haghbeen, K.	A Novel Carbon Paste Electrode for Potentiometric Determination of Vanadyl Ion
53	NSMSI, 34(4) 2016, 31-43	M. Shamsodin; M. Fazli; M. Nasiri; K. Haghbeen	Removal of Strontium (II) from Aqueous Solution by Adsorption Using Xerogel Synthesized by TEOS: Kinetics and Thermodynamics Study
54	J. Food Biochem. DOI: 10.1111/jfbc.12199 2016, 40(1) 100–108	S. Javadian, F. Sabouni, K. Haghbeen*	Origanum vulgare l. Extracts versus thymol: an Anti-inflammatory study on activated microglial And mixed glial cells
55	J. Enz Inhib. Med. Chem. 2016; 31(6):1162-9. doi: 10.3109/14756366.2015.1103234	F. Mirazizi, A. Bahrami, K. Haghbeen*, M. Bakavoli, H. Shahbani Zahiri R. L. Legge	Rapid and direct spectrophotometric method for kinetics studies and routine assay of peroxidase based on aniline diazo substrates
56	J. Plant Process and Function. 2016; 5 (16) :105-116	Zeinali N, Haghbeen K, Delshad M.	Water deficit effects on some physiological characteristics, sugars, and proline as osmolytes in Cucumis melo var. reticulates cv. Samsoury.
57	J IRAN CHEM SOC (2016) 13: 957. doi:10.1007/s13738-016-0811-4	K. Haghbeen*, R L. Legge	Synthesis of a novel class of chromophoric cross‑linkers
58	Separation Sci. Technol. (2016) 51, 9, DOI:10.1080/01496395.2016.1165251	M. Nadimifara, H. khorshidia, K. Haghbeena*, A.A. Karkhanea	A Facile and Cost-Effective Method for Simultaneous Preparation of Lectin and Tyrosinase from Edible Mushroom

Publications (5)
59	Brazil. J Microbiol. 2016, 47(4): 931–940	N. Aliabadi, S. Aminzadeh∗, A.A. Karkhane, K. Haghbeen	Thermostable Chitinase from Cohnella sp. A01: Isolation and Product Optimization
60	Eur. J. Med. Chem. 2016, 21;122:138-48. doi: 10.1016/j.ejmech.2016.06.013	S. Hassani, K. Haghbeen,* M. Fazli	Non-specific binding sites help to explain mixed inhibition in mushroom tyrosinase activities
61	Applied Biochem. Microbiol. 2016, 52(3), 304–310	N. Gheibia, S. Hosseini Zavareh, G. R. Rezaei Behbahani, K. Haghbeen, M. Sirati-sabet, D. Ilgharid, and K. Goodarzvand Chegini	Comprehensive Kinetic and Structural Studies of Different Flavonoids Inhibiting Diphenolase Activity of Mushroom Tyrosinase
62	Trop. plant pathol. 2016, 41(6) 350–356 DOI: 10.1007/s40858-016-0103-7	A. Ataei, M. Zamani, M. Motallebi, K. Haghbeen	Increased antifungal activity of Chit42 from Trichoderma atroviride by the addition of a chitin-binding domain
63	3 Biotech. 2016, 6(2): 129. doi: 10.1007/s13205-016-0441-7	N. Mohandesi, S.O. Ranaei Siadat, K. Haghbeen, A. Hesampour	Cloning and expression of Saccharomyces cerevisiae SUC2 gene in yeast platform and characterization of recombinant enzyme biochemical properties
64	Enz. Microbial Technol. 2017, 96, 14–22.	N. Mohandesi, K. Haghbeen,∗ O. Ranaei, S.S. Arab, S. Hassani	Catalytic efficiency and thermostability improvement of Suc2 invertase through rational site-directed mutagenesis
65	J Functional Foods 2017, 30, 56–62	N. Zeinalipour, K. Haghbeen*, I. Tavassolian, A.A. Karkhane, J. Ghashghaie	Enhanced production of 3-methylthiopropionic ethyl ester in native Iranian Cucumis melo L. Group Dudaim under regulated deficit irrigation
66	Biocatal. Biotransfor. (2017) 35(1), 1-10	S. M. Moshtaghioun, M. Dadkhah, K. Bahremandjo, K. Haghbeen*, S. Aminzadeh, R. L. Legge	Optimization of Simultaneous Production of Tyrosinase and Laccase by Neurospora crassa
67	J Applied Chem. (2017) 12(42),167-180	Ali Aslrousta; K. haghbeen, A. Akbari, M. Fazli	Investigation of adsorption of Chromium and Copper ions on TEOS xerogel
68	J. Applied Chem. Res., (2017) 11(3), 84-96	K. Haghbeen,* S. Rezaeian, M. Bakavoli	A Synthetic Approach for Evaluation of Cytosinediazonium Susceptibility
69	PLOS ONE, 2017, 12(4): e0175013	F. Zebardast Roodi, S. Aminzadeh, N. Farrokhi, A.A. Karkhane, K. Haghbeen	Cohnella amylo pullulanases: Biochemical characterization of two recombinant thermophilic enzymes
70	J. Agri. Sci. Technol. 2018, 20 (2), 347-357	Amiri-nowdijeh, F. Fazelipour, K. Haghbeen, M. Taheri, M. Hosseini-Mazinani	Minor Olive Varieties ITom Iran with Promising Nutraceutical Properties

Publications (6)
71	International J. Environ. Sci Technol. 2018, 15(8): 1679-1686	F. Mirazizi, A. Bahrami, S. Soleimani Asl, A. Zaribafan, K. Haghbeen*, S. Aminzadeh	Evaluation of oxidative enzymes for efficient degradation of aniline and phenolic pollutants
72	Extremophiles, 2018, 22(2): 315-326	K. Khalili Ghadikolaei, J. Gharechahi, K. Haghbeen, K. Akbari Noghabi, G. Hosseini Salekdeh, H. Shahbani Zahiri	A cold-adapted endoglucanase from camel rumen with high catalytic activity at moderate and low temperatures: an anomaly of truly cold-adapted evolution in a mesophilic environment
73	J Iran Chem Soc. 2018, 15 (5), 1097-1106	A. Hashem Nia, S. Rezaeian, H. Eshghi, K. Haghbeen, M. Bakavoli, M. Ramezani	Synthesis and evaluation of apoptosis induction levels of carbamate-and thiocarbamate-functionalized multi-walled carbon nanotubes
74	International J Biol Macromol. 2018, 114, 821-829	S. Hassani, B. Gharechaei, S. Nikfard, M. Fazli, N. Gheibi, R. Hardré, R. L Legge, K. Haghbeen	New insight into the allosteric effect of L-tyrosine on mushroom tyrosinase during L-dopa production
75	International J Biol Macromol 2018, 116, 64-70	Z. Emruzi, S. Aminzadeh, A. Karkhane, J. Alikhajeh, K. Haghbeen, D. Gholami	Improving the thermostability of Serratia marcescens B4A chitinase via G191V site-directed mutagenesis
76	Ecotoxicology and environmental safety 2018, 164, 455-466	S. Shahryari, H. Shahbani Zahiri, K. Haghbeen, L. Adrian, K. Akbari Noghabi	High phenol degradation capacity of a newly characterized Acinetobacter sp. SA01: Bacterial cell viability and membrane impairment in respect to the phenol toxicity
77	Applied Biochem. Biotechnol., 2019, 187 (3), 744-752	E. Khosravi, A. Mousavi, M. Farhadpour, J. Ghashghaie, F. Ghanati, K. Haghbeen	Pyrrolizidine Alkaloids-Free Extract from the Cell Culture of Lithospermum officinale with High Antioxidant Capacity
78	J. Marine Sci. Technol. 2019, 18(2) ; 66-75	Nateghzadeh M., Matroodi S., Haghbeen K.	Comparative Antioxidant Activities and Polyphenolic Content of Marine actinomycetes from Deylam nearshore sediments
79	Heliyon 2019,5 (9), e02543	M Shafiei, F Afzali, AA Karkhane, SM Ebrahimi, K Haghbeen	Cohnella sp. A01 laccase: thermostable, detergent resistant, anti-environmental and industrial pollutants enzyme
80	International J. Farm Sci., 2020,10 (3and4), 98-103	ST Goojgi, A Mousavi, K Haghbeen, K Piri	Morphological changes of Hyoscyamus niger calli resulting from somaclonal variation using ISSR markers
81	Spectrochimica Acta Part A: Mol. Biomol. Spectroscopy 2020, 229, 117897	P Mohammadnejad, SS Asl, S Aminzadeh, K Haghbeen	A new sensitive spectrophotometric method for the determination of saliva and blood glucose
82	Mol. Biol. Res. Commun. 2020, 9 (1), 23	S Yousefian, T Lohrasebi, M Farhadpour, K Haghbeen	Production of phenolic acids in hairy root cultures of medicinal plant Mentha spicata L. in response to elicitors
83	Plant Cell, Tissue and Organ Culture (PCTOC) 2020,142, 285-297	S Yousefian, T Lohrasebi, M Farhadpour, K Haghbeen	Effect of methyl jasmonate on phenolic acids accumulation and the expression profile of their biosynthesis-related genes in Mentha spicata hairy root cultures

Publications (7)
84	Curr Pharm Biotechnol. 2020, doi: 10.2174/1389201021666201104145439.	M Kheyrollah, F Sabouni, M Farhadpour, K Haghbeen	Neuroprotective effect of Lithospermum officinale callus extract on inflamed primary microglial cells
85	Msystems 2021, 6 (1), doi.org/10.1128/mSystems.01175-20	S Shahryari, M Talaee, K Haghbeen, L Adrian, H Vali, HS Zahiri,	New Provisional Function of OmpA from Acinetobacter sp. Strain SA01 Based on Environmental Challenges
86	Plant Cell, Tissue and Organ Culture (PCTOC), 2021, 146, 375–386	P Mohammadnejad, SS Asl, Z Rasoulian, S Aminzadeh, J Ghashghaie	A potent peroxidase from solid cell culture of Ocimum basilicum with high sensitivity for blood glucose determination
87	J Food Biochem, 2021,45 (11), e13949	N Ghorbanian, A Mousavi, MJ Marefatjoo, NS Ghofrani, T Lohrasebi, K. Haghbeen	Toward a more specific inhibitor for Solanum tuberosum polyphenol oxidase through structural insight into its activities and inhibition
88	International Journal of Biological Macromolecules, 2021, 187(30), 373-385	Z. K. Mazraeh Shahi, Z. Takalloo, J. Mohamadzadeh, R. H Sajedi, K. Haghbeen, S. Aminzadeh	Thermophilic iron containing type superoxide dismutase from Cohnella sp. A01
89	The protein journal, 2021, 40 (5), 689-698	NS Ghofrani, M Sheikhi, …, K. Haghbeen	New Insight into the Interactions of Arbutin with Mushroom Tyrosinase
90	J Environmental Science and Health, Part A, 2021, 56 (10), 1131-1137	Z Javaheri Safa, A Olya, M Zamani, M Motalebi, R Khalili, K Haghbeen	Biodegradation of cyanide to ammonia and carbon dioxide by an industrially valuable enzyme from the newly isolated Enterobacter zs
91	J Iranian Chemical Society, 2021,1-12	F Haghbeen, N Ghorbanian, G Hajatpour, …, H Eshghi, K Haghbeen	Introducing a potential lead structure for the synthesis of more specific inhibitors of tyrosinases and catechol oxidases
92	Iranian Journal of Genetics and Plant Breeding, 10(1): 39-46, 2021	Tavakoli M., Mousavi A.,and Haghbeen K.	Evaluation of somaclonal variation of Arnebia pulchra (Boraginaceae) calli versus seeds using ISSR Marker
93	Phytochemistry, 2022, 194, 113022	SS Asl, AA Karkhane, JZ Amirzakaria, KA Noghabi, J Ghashghaie	Structure and activity of a novel robust peroxidase from Alkanna frigida cell culture
94	Biotechnology Letters, 2022,1-8	ST Goojgi, M Tavakoli, K Haghbeen, A Mousavi, K Piri	A novel spray bioreactor for the proliferation of plant callus; Hyoscyamus niger and Arnebia pulchra
95	Scientific Reports 12 (1), 10301. 2022	S Mohammadi, H Tarrahimofrad, S Arjmand, J Zamani, K Haghbeen, ...	A Expression, characterization, and activity optimization of a novel cellulase from the thermophilic bacteria Cohnella sp. A01
96	Journal of Food Biochemistry 46 (10), e14279. 2022	N Taherkhani, A Hekmat, H Piri, K Haghbeen	Structural and inhibitory effects of fulvic and humic acids against tyrosinase

Publications (8)
97	Applied Chemistry 17 (63), 151-164, 2022	F Mirazizi, M Bakavoli, K Haghbeen, M Ebrahimi	Influential parameters on the substrate selectivity of laccase and tyrosinase
98	Journal of Inflammatory Diseases Volume 0, Issue 0 (5-2023)	N Taherkhani, A Hekmat, H Piri, K Haghbeen	Humic and Fulvic acids induced thermodynamic and structural instability of tyrosinase with antiproliferative effect on A375 melanoma cancer cell line
99	Biotechnology and Bioprocess Engineering DOI 10.1007/s12257-023-0049-9. 2023	Reyhane Zamani, Sayyed Shahryar Rahpeyma	Enhancing the Thermostability of Cellulase from Clostridium thermocellumvia Salt Bridge Interactions
100	Journal of Cleaner Production 406, 137126, 2023	M Golbabaie, A Khosronejad, AA Baharanchi, MJ Marefatjoo	Enzymatic remediation of water resources by a durable and potent peroxidase from the cell culture of Origanum vulgare
101	Sustainable Environmental Research	M Golbabaie, B Gharachei, F Mirazizi, AA Baharanchi, A Khosronejad, AA Karkhanie K Haghbeen	Efficient degradation of various recalcitrant azo dyes in an aqueous medium by immobilized Origanum vulgare peroxidase

Books & Chapters

1 -	Biotechnological Production of Plant Secondary Metabolites, Edited by Ilkay Erdogan Orhan	Translated to Persian, Published by NIGEB in 2021
2 -	Benefits and challenges of olive biophenols: a perspective, By H Rasouli, MH Mazinani, K Haghbeen*	In "Olives and Olive Oil in Health and Disease Prevention", 489-503
3 -	Treatment and valorization of olive mill wastewater By P Mohammadnejad, K Haghbeen, H Rasouli*	In “Olives and Olive Oil in Health and Disease Prevention”, 505-519
4 -	Laccases in the Context of Potentially Cooperating Enzymes By K Haghbeen, D Schlossser	In “Laccases in Bioremediation and Waste Valorisation”, 79-114

Patents

1 -	The technology of in-vitro production of Arnebia euchroma root
2 -	Enzymatic production of L-dopa

International proceedings and presentations
1	A Facile Method For Synthesising Diazo Catechol Dyes Used As Chromophoric Substrates For Tyrosinase	K. Haghbeen*, E. W. Tan	Molecules For Future) (University Of Otago, Dunedin 2-6 December 1996)
2	Mix-Cooperativity In The Mushroom Tyrosinase Activities	K. Haghbeen*, E. W. Tan	15th FAOBMB Symposium, Perspectives Of Biochemistry And Molecular Biology In The 21 Century (Beigin, China, October 21-24, 2000)
3	Preliminary Experiments On Cell Culture Of Iranian Arnebia Euchrom Root Seems Quite Promising	K. Haghbeen*, A. Meshkat, S. Poormolaee	First International Congress On Plant Metabolomics (Wageningen, Netherlands, April 7-11, 2002)
4	Calorimetric Studies Reveal Inhibition of The Catecholase Reaction Of Mushroom Tyrosinase By The Nitrated Diazo Derivatives Of Catechol	K. Haghbeen*, B. Zamani	8th European Symposium On Thermal Analysis And Calorimetry (Barcelona, Spain, August 25-29, 2002)
5	Efficient Competitive Inhibitor Lets Resonance Raman Studies On Cresolase Activity Of Mushroom Tyrosinase	B. Zamani, K. Haghbeen*, A.A. Sabouri	Biophysical Society (46th Annual Meeting, February 23-27) Biophysical Journal, Vol 82No 1, Part2, 2134-Pos, (2002)
6	Kinetic Evidence For The Allostric Behaviour Of Mushroom Tyrosinase	F. Karbasi, K. Haghbeen*, A. A. Sabouri	Biophysical Society (46th Annual Meeting, February 23-27) Biophysical Journal, Vol 82No 1, Part2, 2133-Pos, (2002).
7	Non-Enzymicide Substrate For The Catecholase Reaction Of Mushroom Tyrosinase	Farhad Karbassi¹, Kamahldin Haghbeen², Ali Akbar Saboury¹	Biophysical Journal, February 2003, Volume 84, Number 2, Part 2 Of 2 1692-Pos Board # B64 2003
8	Inhibition Studies On The Catecholase Reaction Of Mushroom Tyrosinase Failed To Produce Normal Dixon Plots	K. Haghbeen¹, Ali Akbar Saboury², Bita Zamani², Ali Akbar Moosavi-Movahedi²	Biophysical Journal, February 2003, Volume 84, Number 2, Part 2 Of 2 1693-Pos.
9	Organogenesis Ability Of The Arnebia Euchroma Callus”	K. Haghbeen, K. Rahimi*, S. A. Mohammadi, M. Valizadeh	Fifth International Plant Tissue Culture & Biotechnology Conference From At. (Dhaka, Bangladesh, December 4- 6, 2004)
10	Rhodococcus : Multi-Purposes Micro-Organism	B. Nazari, K. Haghbeen*	10th International Congress For Culture Collections (Tsukuba, Japan, October 10-15, 2004)
11	The Effects Of Copper And Nickel Ions On The Activity And Stability Of Mushroom Tyrosinase”	F. Karbasi*, N. Gheibi, A.A. Sabouri, K. Haghbeen	Biophysical Society (49th Annual Meeting, February 12-16) Biophysical Journal, (2005)
12	Novel Optical Ph Sensors Based On Catechol Azo Dye Derivatives	S. Rouhani*, S. Salimi, K. Haghbeen	International Conference Analytical Chemistry And Chemical Analysis, 12-18 Sep. 2005, Keiv, Ukraine

International proceedings and presentations (2)
13	Studying The Apoptosis-Inducing Activity Of Shikonin	F. Sabouni*, S.H. Abbasi, K. Haghbeen, S.Z. Bathaie	First ICBMB, Tehran, Iran, Sep. 11-15, 2005, Clinical Biochemistry, 38 (9), 2005, Abs. 90
14	Efficient Medium Engineering For Tyrosinase Durability	Haghbeen, K*.; Jahangeeri, E.	1th Nternational IUPAC Conference On Green Chemistry, Dresden, Germany, Sep. 10-15; 2006
15	Simple Reactions For Biomimic Purposes; Versatility of Imines As Chelating Ligands	Haghbeen, K.; Mansouri-Torshizi, H	1th Nternational IUPAC Conference On Green Chemistry, Dresden, Germany, Sep. 10-15; 2006
16	Genetic Analysis And Shikimate Assay Of Glyphosphate …	R. Sheikhani, A. Mossavi, P. Jonoubi, K. Haghbeen	11^th IUPAC International Congress Of Pesticide Chem., Kobe, Japan, 6-11 Aug 2006
17	Kinetic Studies Guide To Effective Administration of Tyrosinase Inhibitor	Kamahldin Haghbeen, Fatimah Saied Nematpour	BIT Life Sciences’ 7th Annual Congress Of International Drug Discovery Science And Technology (IDDST) 2009, Shanghai·China
18	Interesting Results From The Preliminary Studies on The Optimization Of The Neurospora Crassa (FGSC #321) Growth And Laccase Production	Seyed Mohammad Moshtaghioun,1,2 Kamahldin Haghbeen1	16th National And 4th International Conference Of Biology, Ferdowsi University Of Mashhad, Mashhad, Iran 14-16 September 2010
19	A Direct And Accurate Spectrophotometric Method For Assaying The Laccase	S.M. Moshtaghioun, K. Haghbeen	Oxizymes & 9^th International Symposium On Peroxidases Leipzig-Germany 14-16 June 2010
20	Biochemical Characterization Of The Peroxidase Extracted From The Arnebia Euchroma Callus	S. Farhadi, K. Haghbeen	Oxizymes & 9^th International Symposium On Peroxidases Leipzig-Germany 14-16 June 2010
21	Stability And Kinetics Parameters Of Mushroom Tyrosinase In One-Phase Binary Medium	E. Jahangiri, K. Haghbeen	Oxizymes & 9^th International Symposium On Peroxidases Leipzig-Germany 14-16 June 2010
22	Interesting Results from the Preliminary Studies on the Optimization of the Neurospora crassa (FGSC#321) Growth and Laccase Production	S.M. Moshtaghioun, K. Haghbeen	16th National and 4th International Conference of Biology, Ferdowsi University of Mashhad, Iran 14-16 September 2010
23	Bioethics; Can scientists meet a global consensus?	K. Haghbeen*, E. Karimi, F. Ahmadpour, R. Heidari, H. Khorshidi	2^nd International Congress of Bioethics; 5-7 Feb 2011, Tehran, Iran
24	Tyrosinase immobilization on the magnetized hybrid xerogels with controllable binding sites	B. Gharehchei, S. Nikfard, M. Baharloui, D. Schlosser, K. Haghbeen	Oxizyme 2014, Vienna

Supervised research theses
* National Research Institute for Genetic Engineering and Biotechnology (NIGEB) Science and Research Unit of Azad University (SRU-AU) * Iran University of science and Technology (IUST) ** Islamic Azad University (IAU) * Payam Noor University (PNU) * Chemistry & Chem Eng Res Center of Iran (CCERCI) * Institute of Biochemistry & Biophysics (IBB**)
1	Shikonin production by selected cell-lines of Iranian Arnebia euchroma (A. Meshkat)- SRU-AU	MSc	March 2002

2	Spectroscopic and calorimetric examination of inhibition of oxidase activity of tyrosinase (B. Zamani) – Birjand Un.	MSc	March 2002

3	Biosynthesis pathway of shikalkin in Arnebia euchroma (S. Pourmolaei) - SRU-AU	MSc	Jan. 2003

4	Purification and assessment of tyrosinase from edible mushroom (S. Sharifi) - SRU-AU	MSc	Jan. 2003

5	Study on rosmarinic acid production by the Lithospermum officinale callus (E. Pourazizi) - SRU-AU	MSc	July 2003

6	Biosynthetic pathway of shikalkin in the Lithospermum officinale root (F. Ghafarri) - SRU-AU	MSc	2004

7	Thermodynamic of Agaricus bisporus tyrosinase activities (F. Karbasi) – IBB, Tehran Un.	PhD	July 2004

8	Molecular & biochemical aspects of cholesterol oxidase production in Rhodococcus erythropolis ATCC4277 – (B. Nazari) – Tehran Un.	MSc	Sep 2004

9	Evalution of enzymatic activity of Arnebia euchroma callus for biotransformations (M. Ghiami Hoor)- IUST	MSc	May 2005

10	PEGylation technology consideration on Bovine Serum Albumin (E. Mobedi) CCERCI.	MSc	June 2005

11	Tyrosinase efficiency enhancement through immobilization on solid phase (R. Agharafeie) – IUST	MSc	April 2005

12	Examining the effects of some metal ions and synthetic ligands on the activity and active structure of mushroom tyrosinase – (N. Gheibi) – IBB, Tehran of Un.	PhD	2005

13	Agrobacterium effect on the Arnebia euchroma callus (K. Rahimi)- Tabriz Un.	MSc	May 2005

Supervised research theses (2)

14	Extraction and purification of Neurospora crassa tyrosinase (M. Babaei Khalili) – Guillan Un.	MSc	Feb 2006

15	The effect of thiophenol on the activity of tyrosinase (S. Zolghadri-Jahromi) – IBB - Tehran of Un.	MSc	Sep 2006

16	Study on mushroom tyrosinase inhibition by new synthetic ligands (M. Alijanzadeh) – IBB, Tehran Un.	MSc	Feb 2007

17	Functional stability of mushroom tyrosinase in a medium containing water and acetonitrile (E. Jahangeeri) - PNU	MSc	March 2007

18	Study on active site of mushroom tyrosinase in secondary and tertiary structures (R. Khoshneviszadeh). IAU	MSc

19	Study on Banana tyrosinase and its role in enzymatic browning (F.S. Nematpour) SRU-AU	PhD	Feb. 2008

20	Leuprolide acetate stability study in formulations by different spectroscopic methods - (N. Bahmanyar) – IAU	MSc	2006

21	Effects of shikonin on activation and apoptosis of inflamed microglial cells in vitro - (M. Alizade) – Mashhad Un.	MSc	Sep 2007

22	Electrophoretic pattern of cytoplasmic proteins of Agaricus bisporus (A. Ansariyan) SRU-AU	MSc	Feb. 2010

23	Extraction and purification of peroxidase from Arnebia euchroma callus (S. Farhadi) SRU-AU	MSc	Feb. 2010

24	Expression of acetyltransferase gene in tobacco (A. Ahmadizadeh) – NIGEB	MSc	Dec. 2010

25	The antioxidant ability of Arnebia euchroma callus in comparison with its natural root - (N. Amin Tehrani) – PNU	MSc	Sep 2010

International proceedings and presentations (3)

25	Chemical oxidation versus enzymatic oxidation of azo dyes	F. Mirazi, A. Bahrami, K. Haghbeen	Oxizyme 2014, Vienna
26	Combining laccase and tyrosinase for the biodegradation of environmental micro-pollutants	E. Jahangiri, K. Haghbeen, D. Schlosser	Oxizyme 2014, Vienna
27	Callogenesis and organogenesis in medicinal plant; Lithospermum officinalis	E. Khosravi, K. Haghbeen, A. Mosavi, F. Ghanati	19th National & 7th International Congress of Biology (30-31 Aug 2016); Tabriz - Iran
28	Measuring antioxidant power of plant callus of Origanum Vulgare	F. Ghaseminsb, Z. Rasoulian, K. Haghbeen, M.J. Marefatjoo	First International Congress of Biotechnology, 24-26 May 2015, Tehran - Iran
29	Study on callus induction in plant of Nonea caspica	Z. rasoulian, F. ghaseminasab, K. haghbin, E. khosravi	First International Congress of Biotechnology, 24-26 May 2015, Tehran - Iran
30	Evaluation of catalase and peroxidase production in callus culture of medicinal plant lemon balm (Melissa officinalis L.)	S, Soleimany, E. Khosravi, K. Haghbeen	First International Congress of Biotechnology, 24-26 May 2015, Tehran - Iran
31			Second International Congress of Biotechnology 2018
32	Adverse effect of latitude on phenolic acids and alkaloids biosynthesis in Lithospermum officinale	E. Khosravi, K. Haghbeen, A. Mosavi	Х lnternational Scientific Agriculture Symposium, AGROSYM 2019" 03- 06 Oct. Jahorina mountain, Bosnia and Herzegovina

Teaching experiences

Undergraduate Courses	Postgraduate Courses

1 - General Chemistry (I), 2 - General Chemistry (II), 3 - Analytical Chemistry, 4 - Organic Chemistry (I), 5 - Organic Chemistry (II), 6 - Organic Chemistry (III), 7 - Biochemistry (Basic), 8 - Environmental Chemistry, 9 - Principle of Organic Synthesis, 10 - Physical Organic Chemistry, 11 - Separation and Identification of Organic Compounds, 12 - Applications of Spectroscopic Methods	13 - Biochemistry (Advanced), 14 - Cellular Biophysics, 15 - Transport phenomena in living organisms, 16 - Biochemical and Biophysical Methods in Bioscience, 17 - Applied Enzymology

Supervised research theses (3)

26	Antioxidant activity of the Lithospermum Officinalis callus (F. Fazelipour) - PNU	MSc	Sep 2010

27	Adsorption of heavy metal ions on xerogels (F. Broumand) – Semnan Un.	MSc	Sep 2010

28	Studying the Tyrosinase production in Neurospora crassa – (M. Dadkhah) – PNU	MSc	Feb 2011

29	Surveying the function and stability of laccases enzyme in non conventional media (K. Bahremandjooy) – PNU	MSc	2011

30	Simultaneous production of laccase and tyrosinase by Neurospora crassa (M. Moshtaghioun) - NIGEB	PhD	2011

31	Investigation of adsorption effect of metal ions Cd, Zn and Ni on TEOS & TMOS Xerogels (M. Safarpour) – Semnan Un.	MSc	Aug 2011

32	Investigation of adsorption of Chromium & Copper ions on TEOS & TMOS xerogels (M. Naserelami) – Semnan Un.	MSc	Oct 2011

33	Callus production from Nigella sativa L. Seeds and study of anti-inflammatory effects of the extracted oli from seed and callus on Rat brain mix cells - (M. Alemi) – NIGEB.	MSc	Sep 2011

34	Ontogeny of L-gulonolactone oxidase enzyme gene expression in Persion sturgeon, Acipenser persicus (A. Akbarzadeh) TehranUn.	Ph.D	Sep 2011

35	Surveying drought stress on melons (N. Zeinali)- Tehran Un.	PhD	Feb 2012

36	Assisted adsorption of Metal ions on TEOS xerogel by oxalic acid (E. Kianejad) – Semnan Un.	MSc	Feb 2012

37	Investigation of adsorption metal ions Cd²⁺ and Ni²⁺ on Alominum (S. Sadeghian) – Semnan Un.	MSc	Sep 2012

38	Hairy roots induction in Arnebia euchroma by Agrobacterium rhizogenesis (T. Ezati) – NIGEB	MSc	Feb 2012

39	Surveying the Inhibition of the Cresolase and Catecholase Activities of Tyrosinase at low concentrations of Kojic acid , 2-ketohexanoic acid and pyruvic acid - (Y. Tahmasebi) – NIGEB	MSc	Sep 2012

40	Evaluation of the efficiency of phenols and aromatic compounds removal from drinking water resources by advanced oxidation and enzymatic processes - (A. Zaribafan) – Shahid Chamran Un.	MSc	Feb 2012

41	Extraction and purification of lectin from the edible button mushroom (Agaricus bisporus ) and evaluation of its hemagglutinin activity in the presence of ABO blood groups cells – (H. Khorshidi) - NIGEB	MSc	Feb 2012

42	Investigation of adsorption effect of Chlorophenol pollutants on TEOS & TMOS Xerogels in the presence of metal ions - (A. Ghasemi) – Semnan Un.	MSc	Sep 2012

Supervised research theses (4)

43	Induction and growth of Onosma dasytrichum callus (S. Bagheri) – PNU	MSc	Aug. 2012

44	Study on Organogenesis Ability of the Arnebia euchroma Callus (M.J. Marefatjoo) - IAU	MSc	Aug. 2012

45	Investigation of adsorption organic pigments on TEOS Xerogel absorbent – (A. Mohebbi) – Semnan Un.	MSc	Oct 2012

46	Adsorption of metal cations on ormosils of TMOS (A. Zarghami) – Semnan Un.	MSc	Sep 2013

47	Examining the kinetic and Thermodynamic stability of the immobilized mushroom tyrosinase on the modified xerogels (B. Gharehchei) – Semnan Un.	MSc	March 2013

48	Study the kinetic of L-dopa production by free and immobilized mushroom tyrosinase (S. Nikfard Zakelebari) – Semnan Un.	MSc	March 2013

49	Examining the adsorption and desorption of bi-valent metal cation (Cu(II)) on the ormosils derivatized from teraethoxy-ortho-silane - ( N.Shakarami)- Semnan Un.	MSc	Sep 2013

50	Studying the interaction of Lectin and Tyrosinases of edible mushroom Agaricus bisporus - (M. S. Nadimi far) NIGEB	MSc	March 2014

51	Studying Shikalkin production by the callus of Iranian Arnebia euchroma in the presence of Methyl jasmonate , Salicylic acid and Rhizoctonia solani as elicitors - (P. Arghavani) NIGEB	MSc	Feb 2014

52	Determination of optimum condition for Origanum vulgare callus induction and study of anti-inflammatory effects of plant extract on rat brain mix glial cell culture (S. Javadian) IAU.	MSc	Jan. 2013

53	Degradation of diazo dyes by Neurospora crassa laccase (A. Bahrami) IUST	MSc	Nov. 2013

54	Surveying Influential Parameters on the Production invertase by saccharomyces cerevisiae(M. Ghasemi) – Semnan Un.	MSc	March 2015

56	Study on in vitro optimization of Arnebia euchoma root proliferation and its pigment production (F. Ghaseminasab) PNU	PhD	Feb 2015

57	Examination of antioxidant capacity of Nonea caspica and Melissa officinalis Calli - (Z. Rsoulian) – PNU	Msc	Aug 2015

Supervised research theses (5)

58	Functionalization of multi-wall cabon nanotube and their biological evaluation Synthesis of new heterocyclic system7,8-dihydro-6H benzotetrazolo thiadiazines and derivatives Synthesis of substituted tetrahydropyridine with novel catalyst preyssler heteropolyacid supported on the surface of nano magnetic silica Synthesis of new derivatives of benzo[g]pteridine (Sh. Rezaeian) – Mashhad Un.	PhD	March 2015

59	Evaluation of the surface hydrophobicity of the porous polymers on the concentration of alkyphenols in aqueous medium - (M. Baharlouie Yancheshmeh) – IAU.	MSc	Feb 2016

60	Evaluation of polyphenoloc contents and antioxidant activity in cell suspention cultures and optimization of genomic DNA and RNA extractions in Lithospermum officinale L. (N. Faridi) NIGEB	MSc	March 2016

61	Cloning and expression of Invertase – coding gene in Pichin pastoris and biochemical characterization of the enzyme using rational mutagenesis (N. Mohandesi) NIGEB.	PhD	Oct. 2016

62	Enzymatic oxidation of diazo dyes (F. Mirazizi) – Mashhad Un.	PhD	Aug 2016

63	Study of apple (Malus domestica Borkh.) tyrosinase inhibition by som of biological componds - (S. Kompanisaeid) – Kharazmi Un.	MSc	Sep 2016

64	Inhibition of mushrrom tyrosinase by carboxylic acids (S. Hassani) - Semnan University	PhD	Aug 2016

65	Diversity of Gene Clusters for Polyketide in actinomycetes (M. Nateghzadeh) – Khoramshahr Marine Science University	MSc	Jan 2017

66	Flavonoids production in Nonea caspica callus (A. Hamzepour) - PNU	MSc	Aug 2017

67	Activities of Oxidoreductases during proliferation of Lithospermum officinale callus (N. Soltani) - NIGEB	MSc	Feb 2017

68	PPO activity and phenolic metabolites production in Onosma dasytrichum callus (M. Sheikhi) - NIGEB	MSc	Feb 2017

69	Effects of Lithospermum officinale callus extract on activation and apoptosis of inflammated microglial cells in vitro – (M. Kheyrollah) - Esfahan Un.	MSc	Sep 2017

70	Evaluation of inhibition of polyphenol oxidase in potato plant (Solanom tuberosum) (N. Ghorbanian) - NIGEB	MSc	March 2018

71	Investigation on peroxidase performance from ocimum Bassilicum`s calluse for detection of cholesterol and Glucose in natural samples (P. Mohammadnejad) - NIGEB	MSc	Feb 2018

72	Competetive biosynthetic routes of phenolic acids in medicinal plants “Lithospermum officinale and Onosma dasytrichum” (S. Nezami) - NIGEB	MSc	Feb 2019

73	Investigation of the effective factors on callus propagation and expression of some key genes during cell cycle of medicinal plant; Lithospermum officinale L. (E. Khosravi) - SRU-AU	PhD	Aug 2018

74	Computational Analysis of strong inhibitors of mushroom tyrosinase at low and high concentrations in the presence of p-coumaric acid (S. Shamaie) - NIGEB	MSc	Aug 2019

75	Production of neurospora crassa tyrosinase by gene expression in E. coli and evaluation of enzyme activity (G. Hajatpour) - NIGEB	MSc	Aug 2019

76	Effect of methyl jasmonate on phenolic acids accumulation and the expression profile of their biosynthesis-related genes in Mentha spicata hairy root cultures (E. Yousefian) - SRU-AU	PhD	Aug 2020

77	Function of OmpA from Acinetobacter sp. Strain SA01 Based on Environmental Challenges (E. Shahriyari) - SRU-AU	PhD	Feb 2021

78	Study of peroxidase isozyme in Alkanna frigida (S. Soleimani Asl) - NIGEB	PhD	Sep 2021

79	Investigation on feeding strategy of the influential nutrients for propagation of Arnebia pulchra cells in a spray bioreactor (M. Tavakoli) - NIGEB	PhD	Sep 2022

80	Optimization of total alkaloids production in Papaver orientale callus (S. Tahmasbi) - NIGEB	PhD	Sep 2022

81	Physicochemical studies on peroxidase of Origanum vulgare callus with emphasize on potential environmental applications for removal of phenolic pollutants (M. Golbabaei) - NIGEB	PhD	Sep 2023

82	Evaluation of radish (Raphanus sativus) peroxidase coupled reactions with glucose oxidase, cholesterol oxidase, and urease in comparison to the reactions of HRP obtained from the solid cell culture of Armoracia rusticana (Ali Khosrownejad) - NIGEB	PhD	Current