پروژه ها

1. بررسی پایگاه‌های داده آلرژن و مطالعه تطبیقی آنها به منظور آنالیز آلرژنیسیته پروتئین‌های نوترکیب
2. بررسی و شناسایی موتیف‌های سرکوب‌کننده ایمنی در باکتری‌های پروبیوتیک Lactobacillus, Bifidiobacter به‌منظور توسعه سویه‌های آنتی‌آلرژیک پروبیوتیک
3. کاهش فعالیت گلوتامینازی آنزیم آسپاراژیناز به روش In Silico
4. بررسی جنبه‌های آلرژنتسیته ال- آسپارژیناز II برمبنای مطالعات اپی‌توپی، داکینگ و دینامیک مولکولی، سنتز ژن ansB موتانت کم آلرژنیسیته و همسانه‌سازی و بیان آن در E.coli
5. بررسی، تعیین و توسعه سویه های آنتی آلرژیک پروبیوتیک Lactobacillus برمبنای مطالعات آلرژنیسیته، ژنومی و پروتئومی و ارزیابی شاخصهای پروبیوتیکی
6. هدفگیری پروتئین های اتوفاژیک LC3/P62 به منظور یک راهکار درمانی در لاین های سلولی خون
7. بررسی داکینگ پپتیدهای باکتریوسین با منشا پروبیوتیکی علیه اجزاء اول و دوم پروتئین S (S1, S2) ویروس SARS-CoV-2 و ارزیابی پتانسیل آنتی پاتوژنیسیته باکتریوسینهای برگزیده (In vitro)
8. طراحی و ساخت سویه نوترکیب تولید کننده اسیدآمینه ال-ترئونین
9. بررسی و طراحی پپتیدهای موثر بر جلوگیری از تجمعات سمی آلفا-سینوکلئین با استفاده از الگوی زیستی ناحیه NAC

 

راهنمایی / مشاوره پایان نامه و رساله های دانشجویی

PhD

1. Assessment and reclassification of plant allergens using conventional algorithms and Pfam database to ascertain the biosafety of transgenic plants, Nasim Rahmani.
2. Investigation and design of bioactive peptides effective in preventing the accumulation of alpha-synuclein with the ability to cross the blood-brain barrier, Maryam Motamedi.
3. Drug repositioning for inhibition of p62 protein and investigating its effect on survival and chemotherapy resistance of cancer cell lines and cancer stem cells, Ali Kian Saei.
4. Docking study and peptide desigening for inactivate RNAse-kinase domine IRE1 and and sensitizing colorectal cancer cells (CRC) to drugs, Alireza Ghanbari.
5. Genomic investigation and determination Immunosuppressive Motifs (ISMs) in probiotic bacteria and their effect on allergic mouse model, Narges Abbasi.
6. Identification and analysis of miRNAs involved in triple-negative breast cancer (TNBC) and investigation of regulatory relationship on target genes, Samira Behroozi.
7. Analysis of the SAL1/OLD101 gene family, identification and evaluation of their miRNA expression and the docking study of SAL1 protein-protein interaction in Arabidopsis thaliana, Azamsadat Mousavizadeh.

MSc

7. Investigation and design a package of probiotic bacteria with the aim of allergenicity reduction using bacterial genomes and allergens sequences databases, Zakie Mazhari
8. Comparative study of genomic and proteomic characteristics of Bacteriocins in probiotic species (Lactobacillus and Bifidobacter) and their ability to inhibit pathogens, Nasrin Darvishi
9. Study of Protein- Protein Interaction Network for Gastric, esophagus and intestine Cancers and Determination of Candidate Proteins for Drug Design, Afrooz Davari
10. Investigation of protein_protein interaction for alpha-glucosidase and study of its inhibitors for finding diabetes treatment, Ali Dehghanian
11. Comparative evaluation of genomics and proteomics Sortase Dependent Proteins (SDPs) in Lactobacillus species and analysis of their quantitative expression, Nahid Javanshir
12. Determination of Suitable Databases for Bioinformatics Allergenicity Assessment of Recombinant Proteins, Abdolmanan Orange
13. In silico Allergenicity and Cross-Reactivity Assessment of Recombinant Drugs Based on Sequence & Structure bases Algorithms, Amin Shafiei
14. Classification of Plant Aeroallergen and Assessment of Their Cross Reactivity Using Conventional Algorithms,Allergen Database and Pfam, Atefeh Ehghaghi
15. Allergenicity Assessment of L-Asparaginase II and Investigation of Molecular Docking of L- Asparaginase II with H1, H2 Antihistamins Groups, Kiomars Goodarzi
16. Investigation and Allergeniciry Reduction of profilin and PR-10 panallergens based on Molecular and Structural Docking, Homayoon Poorhosaini
17. Study of IgE Suppressive Motif (ISM) in Probiotics Bacteria (Lactobacillus and Bifidiobacter) and Comparative Analysis of ISM in Probiotics and Pathogen Bacteria, Amene Rezvani
18. Evaluation of allergenicity and cross-reactivity of Lactobacillus speciesbased on proteome mining and EpETE, Zahra Bigdeli 
19. Specific screening and investigation of docking of inhibitors against Alpha-synuclein fibrillation compared to the effect of Baicalin, Sepidesadat Seyedfatemi
20. Designing and evaluating contraceptive vaccine based on IZUMO1, SACA3 and PH-20 epitopes, Behnam Mortazavi
21. Comparative study of the interaction between Tubulin with its inhibitors and determining appropriate anti-carcinoma drugs, Najme Ghasemi
22. Molecular Identification and Optimization of Growth Conditions of Petroleum Bacteria Isolated from Oil-Contaminated Soil, Maryam Jenabi
23. Evaluation of Sorbase Gene Expression in Iranian Isolated Lactobacillus strains, Sepide Razani
24. Evaluation of GPSA Peptide and Proteomic Assessment of Probiotic Bacteria to Determine their Antidiabetic Properties, Aida Nikkar
25. Bioinformatics analysis of gene expression profiling for identification of key proteins associated with non‑alcoholic fatty liver disease, Maryam Yaraghi
26. Bioinformatics analysis of gene expression profiling for identification of key proteins associated with Parkinson’s disease, Baharak Akbarian
27. Bioinformatics analysis of gene expression profiling for identification of key proteins associated with Hepatocellular carcinoma (HCC), Mrayam Mehvari
28. Study the Cross-talk Between Hepatitis B Virus (HBV) and Hepatocellular carcinoma (HCC), Zohre Khademi
29. Evaluation of diversity and abundance of bacteriocin nisin types (A, Z, F, U, Q) in proteomic and genomic data of probiotic species and ability to inhibit pathogen, Tahereh Aghaei
30. Evaluation of Plantaricin antibacterial peptide (AMP-P) diversity in Lactobacillus probiotic species and comparative evaluation of their antipathogenic activity potential, Asefeh Khazaeian
31. Comparative study of YY peptide effective on type 2 diabetes in the proteomes and genomes of probiotic and non-probiotic bacteria, a network and pathway study and its expression in E. coli, Erfan Fereidoni
32. Investigating the interaction of bacteriocins with probiotic origin, specifically nisin and its derivatives on surface proteins of SARS-CoV2 virus, Bahar Saadaei Jahromi
33. Identification of potential pharmacological targets by bioinformatics analysis of gene expression profiles in non-small cell lung cancer, Fatemeh Afkhaminegad
34. Computational and network pharmacology analysis of medicinal plants as possible natural antivirals in COVID-19, Mahshid Kavoosi
35. The Identification of Key Genes and Pathways in Brain Cancer (GBM) by Bioinformatics Analysis, Zahra Farsi
36. Identification of Key Genes and Potential Drug Targets for Hepatitis B Virus Associated Liver Diseases by Bioinformatics Analysis, Alireza Gholizade
37. Epitope mapping of E-655 to P-779 fragment in human lysosomal acid alpha glucosidase, Mehrnaz Bahrainy
38. Epitope mapping of V-510 to G-643 fragment in recombinant human lysosomal acid alpha glucosidase, Maryam Mohammadi
39. Investigation of interaction of native medicinal plant compounds against Mpro protease of SARS-CoV-2 virus and its determination by HPLC method, Roya Fallah
40. Inhibition of S protein (RBM region) in different strains of SARS-CoV-2 based on fungal compounds: an in silico study, Sara Soleimanian
41.  Systems Biology Assessment and Transcriptome Analysis of the Interaction of Probiotic Bacteria and host in the Anti-Inflammatory Process, Arezu Heydari
42. Investigation of interaction of native medicinal plant compounds against Mpro protease of SARS-CoV-2 virus and its determination by HPLC method, Roya Fallahpour
43. Epitope mapping and engineering of L-asparaginase-2 protein with the aim of reducing immune response, Pegah Akbari Amjad
44. Evaluation of the effect of probiotic bacteriocins on S protein of SARS-CoV-2 virus and evaluation of their anti-pathogenicity by in vitro and in silico methods, Zeinab Dehbashi
45. Investigation and mapping of the effective gene network in Parkinson's disease with a focus on α-synuclein protein and the study, design and synthesis of peptide inhibitor of its aggregates (50-58 residues), Zahra Salmanpour
46. Studying alpha-synuclein gene variants, investigating and designing a peptide that interacts with it (64-72 residues),  with the aim of controlling Parkinson's disease, Ami-Hossein Jabbari

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PATENT

1. The process of allergenenicty assessment of recombinant proteins, Iran, 2016.
2. Motif and Domain Finding in Proteoms Data (Sortase Dependent Proteind (SDPs); A Specific Sample), Iran, 2019.
3. The process of preparing a set of anti-allergy probiotic strains based on genomic comparison of anti-allergy motifs and evaluation of their proteomes allergenenicty, Iran, 2020.

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 SOFTWARE

1. Nahid Javanshir, Ehsaneh Moslem Rezvani, Najaf Allahyari Fard, Gholamreza Ahmadian, ProtScreen: proteome motif scanner, (http://nigebprotscreen.com/)

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 BOOKS/CHAPTERS

1. Najaf Allahyari Fard, GholamReza Ahmadian, Zakieh Mazhari, Nahid Javanshir, Probiotics in Biotechnology, 2019.
2. Najaf Allahyari Fard, Zakieh Mazhari, Nahid Javanshir, Probiotics against allergy (Book Chapter: Human Microbiome), 2020.
3. Arezu Heidari, Farshid Parvini, Najaf Allahyari Fard, Functional foods and antioxidant effects; Emphasizing the role of probiotics, (Book Chapter: Functional Foods), 2022.
4. Narges Malmir, Najaf Allahyari Fard,  Saeed Aminzadeh, Zahra Moghaddassi-Jahromi, L Mekuto, Emerging Cyanide Bioremediation Methods, https://encyclopedia.pub/entry/history/show/66245, 2022.
5. Nasim Rahmani, Najaf Allahyari Fard, Bioinformatics (Nucleotide, Protein, and Genome Databases), 2021, (Under Publication).
6. Najaf Allahyari Fard, Maryam Motamedi, Peptide based Drug Design, 2022. (Under Publication).
7. Nasim Rahmani, Najaf Allahyari Fard, Molecular biotechnology; Principles and Applications of Recombinant DNA, 2022, (Under Publication).