National Institute Of Genetic Engineering and Biotechnology

P.I:Mohammad-Ali Malboobi
Here we provide last mutation observed in Nucleocapsid gene of COVID-19 prevalent in Iran.
We kindly wait your comment or coopration in tracking crona virus project.
Amino acid changes

How to read this table:
- Rows are reference amino acids and columns are changed amino acids. E.g. Row 'A' column 'E' indicates how many 'A' amino acids have been replaced by 'E' amino acids.
- Red background colors indicate that more changes happened (heat-map).
- Diagonals are indicated using grey background color
- WARNING: This table may include different translation codon tables (e.g. mamalian DNA and mitochondrial DNA).

  * - ? A C D E F G H I K L M N P Q R S T V W Y
*     2                                        
-     365                                        
?                                              
A     15 3         1                   1 2 3    
C     21   1     3                   1         1
D     21     1 1   1 1         3               4
E 5   18 1     1   1     1                      
F     24         2         1           3       1
G 1   15   1 1                       2 2   1    
H     12             2                         1
I     30         1     4   1           1 5 1    
K 2   15       1                                
L     30         2         2           1        
M     3                                        
N     6                                        
P     21                   3     3 1   3        
Q 2   18             1     1         2          
R     12   1         1 1               1        
S     27         1         3   1       3        
T     15 1             4       1       1 3      
V     36 3       3     1   5               3    
W     3   1               1                    
Y 1   21   1     1                             2

Nucleotide and amino acid mutations

Here we provide list of mutation observed in Nucleocapsid at gene and protein of COVID-19.
-The position column is nucleotide position in reference genome as NC_045512.2
-The Reference column indicate reference nucleotide in NC_045512.2
-The NS column indicate number of samples that this position have been observed
-The NSR column indicate number of samples with reference nucleotide. Therefore diffrenciate related to Ns indicate number of sample with mutated nucleotide
Contoury Position Reference Alt. NSR NS AAchange
0 Switzerland 27894 A 7948 7948
1 Switzerland 27895 T 7948 7948
2 Switzerland 27896 G 7948 7946
3 Switzerland 27897 A T,G 7948 7945 Lys2*-p.Lys2Glu
4 Switzerland 27898 A 7948 7946
5 Switzerland 27899 A 7948 7947
6 Switzerland 27900 T C 7948 7920 Phe3Leu
7 Switzerland 27901 T C 7948 7944 Phe3Ser
8 Switzerland 27902 T 7948 7948
9 Switzerland 27903 C 7948 7947
10 Switzerland 27904 T 7948 7948
11 Switzerland 27905 T 7948 7948
12 Switzerland 27906 G T 7948 7945 Val5Phe
13 Switzerland 27907 T 7948 7946
14 Switzerland 27908 T 7948 7947
15 Switzerland 27909 T 7948 7948
16 Switzerland 27910 T 7948 7948
17 Switzerland 27911 C 7948 7946
18 Switzerland 27912 T 7948 7946
19 Switzerland 27913 T 7948 7947
20 Switzerland 27914 A 7948 7948
21 Switzerland 27915 G A 7948 7944 Gly8Arg
22 Switzerland 27916 G T 7948 7946 Gly8Val
23 Switzerland 27917 A 7948 7948
24 Switzerland 27918 A 7948 7948
25 Switzerland 27919 T C 7948 7945 Ile9Thr
26 Switzerland 27920 C T 7948 7927 Ile9Ile
27 Switzerland 27921 A T 7948 7945 Ile10Phe
28 Switzerland 27922 T C 7956 7955 Ile10Thr
29 Switzerland 27923 C T 7961 7957 Ile10Ile
30 Switzerland 27924 A G 7961 7958 Thr11Ala
31 Switzerland 27925 C T 7961 7950 Thr11Ile
32 Switzerland 27926 A 7961 7961
33 Switzerland 27927 A 7961 7960
34 Switzerland 27928 C 7961 7960
35 Switzerland 27929 T C 7961 7959 Thr12Thr
36 Switzerland 27930 G A 7961 7944 Val13Ile
37 Switzerland 27931 T C 7961 7960 Val13Ala
38 Switzerland 27932 A 7962 7961
39 Switzerland 27933 G 7962 7957
40 Switzerland 27934 C 7962 7962
41 Switzerland 27935 T A 7962 7951 Ala14Ala
42 Switzerland 27936 G 7962 7961
43 Switzerland 27937 C 7963 7961
44 Switzerland 27938 A G 7963 7961 Ala15Ala
45 Switzerland 27939 T 7963 7962
46 Switzerland 27940 T 7963 7962
47 Switzerland 27941 T 7963 7962
48 Switzerland 27942 C T 7962 7874 His17Tyr
49 Switzerland 27943 A 7962 7962
50 Switzerland 27944 C T 7963 7764 His17His
51 Switzerland 27945 C T 7963 7954 Gln18*
52 Switzerland 27946 A 7963 7963
53 Switzerland 27947 A 7963 7960
54 Switzerland 27948 G T 7963 7960 Glu19*
55 Switzerland 27949 A 7963 7963
56 Switzerland 27950 A 7963 7961
57 Switzerland 27951 T 7963 7962
58 Switzerland 27952 G 7963 7962
59 Switzerland 27953 T 7963 7962
60 Switzerland 27954 A 7963 7961
61 Switzerland 27955 G A 7963 7960 Ser21Asn
62 Switzerland 27956 T 7963 7962
63 Switzerland 27957 T C 7963 7961 Leu22Leu
64 Switzerland 27958 T 7963 7960
65 Switzerland 27959 A 7963 7962
66 Switzerland 27960 C 7963 7962
67 Switzerland 27961 A 7963 7963
68 Switzerland 27962 G 7963 7962
69 Switzerland 27963 T 7963 7962
70 Switzerland 27964 C T 7963 7668 Ser24Leu
71 Switzerland 27965 A 7964 7964
72 Switzerland 27966 T 7964 7964
73 Switzerland 27967 G T,A 7964 7960 Cys25Phe-p.Cys25Tyr
74 Switzerland 27968 T 7964 7964
75 Switzerland 27969 A 7964 7963
76 Switzerland 27970 C T,A 7964 7949 Thr26Ile-p.Thr26Asn
77 Switzerland 27971 T C 7964 7958 Thr26Thr
78 Switzerland 27972 C T 7964 7761 Gln27*
79 Switzerland 27973 A G 7964 7963 Gln27Arg
80 Switzerland 27974 A 7964 7962
81 Switzerland 27975 C 7964 7964
82 Switzerland 27976 A 7965 7965
83 Switzerland 27977 T C 7965 7963 His28His
84 Switzerland 27978 C 7965 7965
85 Switzerland 27979 A T,G 7965 7962 Gln29Leu-p.Gln29Arg
86 Switzerland 27980 A 7965 7965
87 Switzerland 27981 C 7965 7965
88 Switzerland 27982 C T 7965 7746 Pro30Leu
89 Switzerland 27983 A C 7965 7962 Pro30Pro
90 Switzerland 27984 T 7965 7963
91 Switzerland 27985 A 7966 7965
92 Switzerland 27986 T C 7965 7960 Tyr31Tyr
93 Switzerland 27987 G T,C 7965 7952 Val32Leu-p.Val32Leu
94 Switzerland 27988 T 7965 7965
95 Switzerland 27989 A 7965 7963
96 Switzerland 27990 G 7965 7965
97 Switzerland 27991 T 7965 7964
98 Switzerland 27992 T 7965 7965
99 Switzerland 27993 G 7965 7964
100 Switzerland 27994 A 7965 7964
101 Switzerland 27995 T 7965 7965
102 Switzerland 27996 G T 7965 7949 Asp35Tyr
103 Switzerland 27997 A 7965 7964
104 Switzerland 27998 C T 7965 7950 Asp35Asp
105 Switzerland 27999 C T 7965 7959 Pro36Ser
106 Switzerland 28000 C A,T 7965 7948 Pro36Gln-p.Pro36Leu
107 Switzerland 28001 G T 7965 7957 Pro36Pro
108 Switzerland 28002 T 7965 7964
109 Switzerland 28003 G T 7958 7950 Cys37Phe
110 Switzerland 28004 T 7958 7956
111 Switzerland 28005 C T 7958 7956 Pro38Ser
112 Switzerland 28006 C 7958 7954
113 Switzerland 28007 T 7958 7958
114 Switzerland 28008 A G 7958 7955 Ile39Val
115 Switzerland 28009 T C,G 7958 7946 Ile39Thr-p.Ile39Ser
116 Switzerland 28010 T 7958 7956
117 Switzerland 28011 C 7958 7958
118 Switzerland 28012 A 7958 7958
119 Switzerland 28013 C 7958 7958
120 Switzerland 28014 T 7957 7956
121 Switzerland 28015 T 7957 7957
122 Switzerland 28016 C 7957 7955
123 Switzerland 28017 T 7957 7956
124 Switzerland 28018 A 7957 7957
125 Switzerland 28019 T C 7957 7952 Tyr42Tyr
126 Switzerland 28020 T 7957 7956
127 Switzerland 28021 C 7957 7954
128 Switzerland 28022 T 7957 7955
129 Switzerland 28023 A 7957 7956
130 Switzerland 28024 A 7957 7957
131 Switzerland 28025 A 7957 7954
132 Switzerland 28026 T 7957 7957
133 Switzerland 28027 G T 7957 7955 Trp45Leu
134 Switzerland 28028 G T 7957 7950 Trp45Cys
135 Switzerland 28029 T 7958 7957
136 Switzerland 28030 A 7958 7957
137 Switzerland 28031 T 7958 7955
138 Switzerland 28032 A 7958 7955
139 Switzerland 28033 T 7957 7953
140 Switzerland 28034 T 7957 7953
141 Switzerland 28035 A 7957 7950
142 Switzerland 28036 G 7957 7947
143 Switzerland 28037 A T 7957 7945 Arg48Ser
144 Switzerland 28038 G 7957 7944
145 Switzerland 28039 T 7957 7946
146 Switzerland 28040 A 7957 7945
147 Switzerland 28041 G T,A 7957 7938 Gly50*-p.Gly50Arg
148 Switzerland 28042 G 7957 7944
149 Switzerland 28043 A 7957 7946
150 Switzerland 28044 G 7957 7944
151 Switzerland 28045 C T 7957 7917 Ala51Val
152 Switzerland 28046 T 7957 7946
153 Switzerland 28047 A 7957 7945
154 Switzerland 28048 G T 7957 7735 Arg52Ile
155 Switzerland 28049 A 7957 7945
156 Switzerland 28050 A 7957 7944
157 Switzerland 28051 A 7957 7946
158 Switzerland 28052 A 7957 7946
159 Switzerland 28053 T 7957 7944
160 Switzerland 28054 C T 7957 7937 Ser54Leu
161 Switzerland 28055 A 7957 7946
162 Switzerland 28056 G A 7957 7928 Ala55Thr
163 Switzerland 28057 C T 7957 7942 Ala55Val
164 Switzerland 28058 A 7957 7946
165 Switzerland 28059 C T 7957 7944 Pro56Ser
166 Switzerland 28060 C 7957 7943
167 Switzerland 28061 T 7957 7944
168 Switzerland 28062 T 7957 7945
169 Switzerland 28063 T 7958 7944
170 Switzerland 28064 A C 7958 7944 Leu57Phe
171 Switzerland 28065 A 7958 7946
172 Switzerland 28066 T 7958 7946
173 Switzerland 28067 T 7958 7945
174 Switzerland 28068 G T 7958 7943 Glu59*
175 Switzerland 28069 A 7959 7947
176 Switzerland 28070 A 7959 7946
177 Switzerland 28071 T 7959 7946
178 Switzerland 28072 T 7959 7946
179 Switzerland 28073 G 7959 7943
180 Switzerland 28074 T 7953 7940
181 Switzerland 28075 G 7953 7940
182 Switzerland 28076 C T 7953 7938 Cys61Cys
183 Switzerland 28077 G T,C 7953 7857 Val62Leu-p.Val62Leu
184 Switzerland 28078 T C 7953 7937 Val62Ala
185 Switzerland 28079 G T,A 7953 7916 Val62Val-p.Val62Val
186 Switzerland 28080 G T,A 7956 7941 Asp63Tyr-p.Asp63Asn
187 Switzerland 28081 A 7974 7944
188 Switzerland 28082 T 8029 8026
189 Switzerland 28083 G T 8034 8003 Glu64*
190 Switzerland 28084 A C 8034 8030 Glu64Ala
191 Switzerland 28085 G 8034 8029
192 Switzerland 28086 G T,A 8034 7932 Ala65Ser-p.Ala65Thr
193 Switzerland 28087 C T,G 8034 7999 Ala65Val-p.Ala65Gly
194 Switzerland 28088 T A 8034 8021 Ala65Ala
195 Switzerland 28089 G 8038 8036
196 Switzerland 28090 G 8039 8037
197 Switzerland 28091 T 8039 8037
198 Switzerland 28092 T 8039 8037
199 Switzerland 28093 C T 8039 8024 Ser67Phe
200 Switzerland 28094 T 8039 8037
201 Switzerland 28095 A T 8040 7995 Lys68*
202 Switzerland 28096 A 8040 8038
203 Switzerland 28097 A 8040 8039
204 Switzerland 28098 T 8041 8038
205 Switzerland 28099 C 8041 8040
206 Switzerland 28100 A 8041 8040
207 Switzerland 28101 C 8041 8039
208 Switzerland 28102 C 8041 8040
209 Switzerland 28103 C T 8041 8039 Pro70Pro
210 Switzerland 28104 A 8042 8042
211 Switzerland 28105 T 8042 8042
212 Switzerland 28106 T C 8042 8035 Ile71Ile
213 Switzerland 28107 C 8042 8040
214 Switzerland 28108 A 8042 8040
215 Switzerland 28109 G T 8042 8037 Gln72His
216 Switzerland 28110 T 8042 8042
217 Switzerland 28111 A G 8042 7847 Tyr73Cys
218 Switzerland 28112 C 8042 8042
219 Switzerland 28113 A 8042 8042
220 Switzerland 28114 T C 8042 8041 Ile74Thr
221 Switzerland 28115 C 8042 8041
222 Switzerland 28116 G A 8042 8037 Asp75Asn
223 Switzerland 28117 A G 8042 8040 Asp75Gly
224 Switzerland 28118 T A 8042 8040 Asp75Glu
225 Switzerland 28119 A 8042 8042
226 Switzerland 28120 T C 8042 8041 Ile76Thr
227 Switzerland 28121 C 8042 8040
228 Switzerland 28122 G A,T 8042 8029 Gly77Ser-p.Gly77Cys
229 Switzerland 28123 G A 8042 8039 Gly77Asp
230 Switzerland 28124 T 8042 8042
231 Switzerland 28125 A 8042 8042
232 Switzerland 28126 A 8042 8042
233 Switzerland 28127 T 8042 8042
234 Switzerland 28128 T 8042 8042
235 Switzerland 28129 A 8042 8040
236 Switzerland 28130 T 8042 8042
237 Switzerland 28131 A T 8042 8041 Thr80Ser
238 Switzerland 28132 C T 8042 8040 Thr80Ile
239 Switzerland 28133 A T 8042 7816 Thr80Thr
240 Switzerland 28134 G T 8049 8047 Val81Phe
241 Switzerland 28135 T C 8049 8041 Val81Ala
242 Switzerland 28136 T 8049 8048
243 Switzerland 28137 T 8049 8047
244 Switzerland 28138 C 8049 8047
245 Switzerland 28139 C T 8049 8035 Ser82Ser
246 Switzerland 28140 T C 8049 8046 Cys83Arg
247 Switzerland 28141 G 8049 8048
248 Switzerland 28142 T 8049 8048
249 Switzerland 28143 T 8049 8048
250 Switzerland 28144 T C 8049 8034 Leu84Ser
251 Switzerland 28145 A 8049 8048
252 Switzerland 28146 C 8049 8047
253 Switzerland 28147 C 8049 8048
254 Switzerland 28148 T 8049 8048
255 Switzerland 28149 T 8049 8045
256 Switzerland 28150 T 8049 8048
257 Switzerland 28151 T C 8049 8045 Phe86Phe
258 Switzerland 28152 A 8049 8048
259 Switzerland 28153 C T 8049 8039 Thr87Ile
260 Switzerland 28154 A 8048 8046
261 Switzerland 28155 A 8048 8046
262 Switzerland 28156 T 8048 8042
263 Switzerland 28157 T 8048 8045
264 Switzerland 28158 A 8048 8046
265 Switzerland 28159 A 8048 8047
266 Switzerland 28160 T 8048 8047
267 Switzerland 28161 T 8048 8046
268 Switzerland 28162 G 8048 8046
269 Switzerland 28163 C 8048 8043
270 Switzerland 28164 C 8048 8046
271 Switzerland 28165 A 8048 8046
272 Switzerland 28166 G 8048 8045
273 Switzerland 28167 G A 8048 8043 Glu92Lys
274 Switzerland 28168 A G 8048 8046 Glu92Gly
275 Switzerland 28169 A G 8048 8031 Glu92Glu
276 Switzerland 28170 C 8048 8045
277 Switzerland 28171 C T 8048 8031 Pro93Leu
278 Switzerland 28172 T 8048 8048
279 Switzerland 28173 A 8017 8015
280 Switzerland 28174 A 8005 8003
281 Switzerland 28175 A 8003 8002
282 Switzerland 28176 T C 8003 8000 Leu95Leu
283 Switzerland 28177 T 8003 8002
284 Switzerland 28178 G T 8003 7997 Leu95Phe
285 Switzerland 28179 G A 8003 7997 Gly96Ser
286 Switzerland 28180 G 8003 8002
287 Switzerland 28181 T 8003 8001
288 Switzerland 28182 A 8003 8001
289 Switzerland 28183 G 8003 8002
290 Switzerland 28184 T 8003 8002
291 Switzerland 28185 C 8003 7999
292 Switzerland 28186 T 8003 8002
293 Switzerland 28187 T 8003 8002
294 Switzerland 28188 G 8003 8002
295 Switzerland 28189 T 8003 8002
296 Switzerland 28190 A 8003 8002
297 Switzerland 28191 G T 8003 7987 Val100Leu
298 Switzerland 28192 T 8003 7998
299 Switzerland 28193 G T 8003 7996 Val100Val
300 Switzerland 28194 C 8003 8000
301 Switzerland 28195 G A 8003 7993 Arg101His
302 Switzerland 28196 T 8003 8001
303 Switzerland 28197 T 8003 8002
304 Switzerland 28198 G T 8003 7998 Cys102Phe
305 Switzerland 28199 T 8003 8002
306 Switzerland 28200 T 8003 8000
307 Switzerland 28201 C T 8003 7998 Ser103Leu
308 Switzerland 28202 G A,T 8003 7997 Ser103Ser-p.Ser103Ser
309 Switzerland 28203 T 8003 8002
310 Switzerland 28204 T A 8003 8000 Phe104Tyr
311 Switzerland 28205 C 8003 8001
312 Switzerland 28206 T 8003 8002
313 Switzerland 28207 A 8003 8002
314 Switzerland 28208 T A 8003 8001 Tyr105*
315 Switzerland 28209 G T 8003 7977 Glu106*
316 Switzerland 28210 A 8003 8001
317 Switzerland 28211 A 8003 8001
318 Switzerland 28212 G 8003 8001
319 Switzerland 28213 A 8003 8002
320 Switzerland 28214 C 8003 7977
321 Switzerland 28215 T 8003 8003
322 Switzerland 28216 T C 8003 8001 Phe108Ser
323 Switzerland 28217 T 8003 8003
324 Switzerland 28218 T 8003 8003
325 Switzerland 28219 T 8003 8003
326 Switzerland 28220 A 8004 8004
327 Switzerland 28221 G T 8004 8002 Glu110*
328 Switzerland 28222 A 8004 8004
329 Switzerland 28223 G 8004 8003
330 Switzerland 28224 T 8004 8004
331 Switzerland 28225 A T 8004 7973 Tyr111Phe
332 Switzerland 28226 T 8004 8002
333 Switzerland 28227 C 8004 8003
334 Switzerland 28228 A 8004 8004
335 Switzerland 28229 T 8004 8003
336 Switzerland 28230 G T 8004 8001 Asp113Tyr
337 Switzerland 28231 A 8004 8004
338 Switzerland 28232 C 8004 8001
339 Switzerland 28233 G 8004 8004
340 Switzerland 28234 T 8004 8003
341 Switzerland 28235 T 8004 8004
342 Switzerland 28236 C T 8004 7987 Arg115Cys
343 Switzerland 28237 G 8004 8002
344 Switzerland 28238 T 8004 8004
345 Switzerland 28239 G 8004 8003
346 Switzerland 28240 T 8004 8003
347 Switzerland 28241 T 8004 8003
348 Switzerland 28242 G T 8004 8000 Val117Phe
349 Switzerland 28243 T 8004 8003
350 Switzerland 28244 T 8004 8004
351 Switzerland 28245 T 8004 8004
352 Switzerland 28246 T 8004 8004
353 Switzerland 28247 A 8004 8002
354 Switzerland 28248 G T,C,A 8003 7997 Asp119His-p.Asp119Asn
355 Switzerland 28249 A 8003 8003
356 Switzerland 28250 T 8002 8000
357 Switzerland 28251 T 8001 7999
358 Switzerland 28252 T C 8001 7987 Phe120Ser
359 Switzerland 28253 C T 8001 7837 Phe120Phe
360 Switzerland 28254 A C 8001 7986 Ile121Leu
361 Switzerland 28255 T 8001 8001
362 Switzerland 28256 C T 8001 7999 Ile121Ile
363 Switzerland 28257 T 8001 8000
364 Switzerland 28258 A 8001 8000
365 Switzerland 28259 A 8001 8001