National Institute Of Genetic Engineering and Biotechnology

P.I:Mohammad-Ali Malboobi
Here we provide last mutation observed in Nucleocapsid gene of COVID-19 prevalent in Iran.
We kindly wait your comment or coopration in tracking crona virus project.

Amino acid changes

How to read this table:
- Rows are reference amino acids and columns are changed amino acids. E.g. Row 'A' column 'E' indicates how many 'A' amino acids have been replaced by 'E' amino acids.
- Red background colors indicate that more changes happened (heat-map).
- Diagonals are indicated using grey background color
- WARNING: This table may include different translation codon tables (e.g. mamalian DNA and mitochondrial DNA).

  * - ? A C D E F G H I K L M N P Q R S T V W Y
*     2                                        
-     366                                        
?                                              
A     15                               1 2 1    
C     21         1                              
D     22     3     1                       1   1
E 2   18     1 2         1         1       1    
F     24         1                              
G 1   15                             1 2   1    
H     12             1                         2
I     30         2     5   1             2      
K     15       1                                
L     30         1                     1        
M     3                                        
N     6                                        
P     21                   3     1     3 1      
Q 1   18             1               1          
R     12             1     2                    
S     27         1         2     1     1        
T     15               1 1               1      
V     36         1     1   2 1             1    
W     3   1                                    
Y     21   1         1                         2

Nucleotide and amino acid mutations

Here we provide list of mutation observed in Nucleocapsid at gene and protein of COVID-19.
-The position column is nucleotide position in reference genome as NC_045512.2
-The Reference column indicate reference nucleotide in NC_045512.2
-The NS column indicate number of samples that this position have been observed
-The NSR column indicate number of samples with reference nucleotide. Therefore diffrenciate related to Ns indicate number of sample with mutated nucleotide

Contoury Position Reference Alt. NSR NS AAchange
0 Netherlands 27894 A 4372 4372
1 Netherlands 27895 T 4372 4372
2 Netherlands 27896 G 4372 4372
3 Netherlands 27897 A G 4372 4370 Lys2Glu
4 Netherlands 27898 A 4372 4372
5 Netherlands 27899 A 4372 4372
6 Netherlands 27900 T 4372 4372
7 Netherlands 27901 T 4372 4372
8 Netherlands 27902 T 4372 4372
9 Netherlands 27903 C 4372 4372
10 Netherlands 27904 T 4372 4372
11 Netherlands 27905 T 4372 4372
12 Netherlands 27906 G 4372 4372
13 Netherlands 27907 T 4372 4372
14 Netherlands 27908 T 4372 4372
15 Netherlands 27909 T 4372 4372
16 Netherlands 27910 T 4372 4372
17 Netherlands 27911 C 4372 4372
18 Netherlands 27912 T 4372 4372
19 Netherlands 27913 T 4372 4372
20 Netherlands 27914 A 4372 4372
21 Netherlands 27915 G 4372 4372
22 Netherlands 27916 G 4372 4372
23 Netherlands 27917 A 4372 4372
24 Netherlands 27918 A 4372 4372
25 Netherlands 27919 T C 4372 4367 Ile9Thr
26 Netherlands 27920 C T 4372 4368 Ile9Ile
27 Netherlands 27921 A T 4372 4367 Ile10Phe
28 Netherlands 27922 T C 4373 4354 Ile10Thr
29 Netherlands 27923 C T 4373 4372 Ile10Ile
30 Netherlands 27924 A 4373 4373
31 Netherlands 27925 C A 4373 4371 Thr11Lys
32 Netherlands 27926 A 4373 4373
33 Netherlands 27927 A 4373 4373
34 Netherlands 27928 C 4373 4373
35 Netherlands 27929 T 4373 4373
36 Netherlands 27930 G 4373 4373
37 Netherlands 27931 T 4373 4373
38 Netherlands 27932 A 4373 4373
39 Netherlands 27933 G 4373 4373
40 Netherlands 27934 C 4373 4373
41 Netherlands 27935 T 4373 4373
42 Netherlands 27936 G 4373 4373
43 Netherlands 27937 C 4373 4373
44 Netherlands 27938 A 4373 4373
45 Netherlands 27939 T 4373 4373
46 Netherlands 27940 T 4373 4373
47 Netherlands 27941 T 4373 4373
48 Netherlands 27942 C T 4373 4371 His17Tyr
49 Netherlands 27943 A 4373 4373
50 Netherlands 27944 C T 4373 4067 His17His
51 Netherlands 27945 C T 4373 4370 Gln18*
52 Netherlands 27946 A 4373 4373
53 Netherlands 27947 A 4373 4373
54 Netherlands 27948 G C 4373 4366 Glu19Gln
55 Netherlands 27949 A 4373 4373
56 Netherlands 27950 A 4373 4373
57 Netherlands 27951 T 4373 4373
58 Netherlands 27952 G 4373 4373
59 Netherlands 27953 T 4373 4373
60 Netherlands 27954 A 4374 4374
61 Netherlands 27955 G 4374 4374
62 Netherlands 27956 T 4374 4374
63 Netherlands 27957 T 4374 4374
64 Netherlands 27958 T 4374 4374
65 Netherlands 27959 A 4374 4374
66 Netherlands 27960 C 4374 4374
67 Netherlands 27961 A 4374 4374
68 Netherlands 27962 G 4374 4374
69 Netherlands 27963 T 4374 4374
70 Netherlands 27964 C 4374 4374
71 Netherlands 27965 A 4374 4374
72 Netherlands 27966 T 4374 4374
73 Netherlands 27967 G T 4374 4373 Cys25Phe
74 Netherlands 27968 T 4375 4375
75 Netherlands 27969 A 4375 4375
76 Netherlands 27970 C T 4375 4374 Thr26Ile
77 Netherlands 27971 T 4375 4375
78 Netherlands 27972 C 4375 4375
79 Netherlands 27973 A 4375 4375
80 Netherlands 27974 A 4375 4375
81 Netherlands 27975 C 4375 4375
82 Netherlands 27976 A 4375 4375
83 Netherlands 27977 T 4375 4375
84 Netherlands 27978 C 4375 4375
85 Netherlands 27979 A 4375 4375
86 Netherlands 27980 A 4375 4375
87 Netherlands 27981 C 4375 4375
88 Netherlands 27982 C T 4375 4374 Pro30Leu
89 Netherlands 27983 A 4375 4375
90 Netherlands 27984 T 4375 4375
91 Netherlands 27985 A 4375 4375
92 Netherlands 27986 T 4375 4375
93 Netherlands 27987 G T 4375 4349 Val32Leu
94 Netherlands 27988 T 4375 4375
95 Netherlands 27989 A 4375 4375
96 Netherlands 27990 G 4375 4375
97 Netherlands 27991 T 4375 4375
98 Netherlands 27992 T 4375 4375
99 Netherlands 27993 G 4375 4375
100 Netherlands 27994 A G 4375 4373 Asp34Gly
101 Netherlands 27995 T 4375 4375
102 Netherlands 27996 G T 4375 4374 Asp35Tyr
103 Netherlands 27997 A 4375 4375
104 Netherlands 27998 C T 4375 4374 Asp35Asp
105 Netherlands 27999 C T 4375 4374 Pro36Ser
106 Netherlands 28000 C T 4375 4372 Pro36Leu
107 Netherlands 28001 G T 4375 4372 Pro36Pro
108 Netherlands 28002 T 4375 4375
109 Netherlands 28003 G 4371 4371
110 Netherlands 28004 T 4371 4371
111 Netherlands 28005 C T 4371 4369 Pro38Ser
112 Netherlands 28006 C 4371 4371
113 Netherlands 28007 T 4371 4371
114 Netherlands 28008 A 4371 4371
115 Netherlands 28009 T 4371 4371
116 Netherlands 28010 T C 4371 4370 Ile39Ile
117 Netherlands 28011 C T 4371 4368 His40Tyr
118 Netherlands 28012 A 4371 4371
119 Netherlands 28013 C 4371 4371
120 Netherlands 28014 T 4371 4371
121 Netherlands 28015 T 4371 4371
122 Netherlands 28016 C 4371 4371
123 Netherlands 28017 T 4371 4371
124 Netherlands 28018 A 4371 4371
125 Netherlands 28019 T C 4371 4370 Tyr42Tyr
126 Netherlands 28020 T 4371 4371
127 Netherlands 28021 C 4371 4371
128 Netherlands 28022 T 4371 4371
129 Netherlands 28023 A 4371 4371
130 Netherlands 28024 A 4371 4371
131 Netherlands 28025 A 4371 4371
132 Netherlands 28026 T 4371 4371
133 Netherlands 28027 G 4371 4371
134 Netherlands 28028 G T 4371 4370 Trp45Cys
135 Netherlands 28029 T 4371 4371
136 Netherlands 28030 A 4371 4371
137 Netherlands 28031 T 4371 4371
138 Netherlands 28032 A 4371 4371
139 Netherlands 28033 T 4371 4371
140 Netherlands 28034 T 4371 4371
141 Netherlands 28035 A 4371 4371
142 Netherlands 28036 G 4371 4371
143 Netherlands 28037 A 4371 4371
144 Netherlands 28038 G 4371 4371
145 Netherlands 28039 T 4371 4371
146 Netherlands 28040 A 4371 4371
147 Netherlands 28041 G T,A 4371 4369 Gly50*-p.Gly50Arg
148 Netherlands 28042 G 4371 4371
149 Netherlands 28043 A 4371 4371
150 Netherlands 28044 G 4371 4371
151 Netherlands 28045 C 4371 4371
152 Netherlands 28046 T 4371 4371
153 Netherlands 28047 A 4371 4371
154 Netherlands 28048 G 4371 4371
155 Netherlands 28049 A 4371 4371
156 Netherlands 28050 A 4371 4371
157 Netherlands 28051 A 4371 4371
158 Netherlands 28052 A 4371 4371
159 Netherlands 28053 T C 4371 4370 Ser54Pro
160 Netherlands 28054 C T 4371 4369 Ser54Leu
161 Netherlands 28055 A 4375 4375
162 Netherlands 28056 G A 4375 4374 Ala55Thr
163 Netherlands 28057 C 4375 4375
164 Netherlands 28058 A 4375 4375
165 Netherlands 28059 C 4375 4375
166 Netherlands 28060 C 4375 4375
167 Netherlands 28061 T 4375 4375
168 Netherlands 28062 T 4375 4375
169 Netherlands 28063 T 4375 4375
170 Netherlands 28064 A 4375 4375
171 Netherlands 28065 A 4375 4375
172 Netherlands 28066 T 4375 4375
173 Netherlands 28067 T 4375 4375
174 Netherlands 28068 G 4375 4375
175 Netherlands 28069 A T 4375 4372 Glu59Val
176 Netherlands 28070 A G 4375 4374 Glu59Glu
177 Netherlands 28071 T 4375 4375
178 Netherlands 28072 T 4375 4375
179 Netherlands 28073 G 4375 4375
180 Netherlands 28074 T 4374 4374
181 Netherlands 28075 G 4374 4374
182 Netherlands 28076 C 4374 4374
183 Netherlands 28077 G T,A 4374 4350 Val62Leu-p.Val62Met
184 Netherlands 28078 T 4374 4374
185 Netherlands 28079 G T 4374 4371 Val62Val
186 Netherlands 28080 G 4375 4375
187 Netherlands 28081 A 4375 4375
188 Netherlands 28082 T C 4375 4374 Asp63Asp
189 Netherlands 28083 G 4375 4375
190 Netherlands 28084 A 4375 4375
191 Netherlands 28085 G T 4375 4374 Glu64Asp
192 Netherlands 28086 G T,A 4375 4365 Ala65Ser-p.Ala65Thr
193 Netherlands 28087 C T 4375 4348 Ala65Val
194 Netherlands 28088 T 4375 4375
195 Netherlands 28089 G A 4375 4374 Gly66Ser
196 Netherlands 28090 G T 4375 4364 Gly66Val
197 Netherlands 28091 T 4375 4375
198 Netherlands 28092 T 4375 4375
199 Netherlands 28093 C T 4375 4356 Ser67Phe
200 Netherlands 28094 T 4375 4375
201 Netherlands 28095 A 4375 4375
202 Netherlands 28096 A 4375 4375
203 Netherlands 28097 A 4375 4375
204 Netherlands 28098 T 4375 4375
205 Netherlands 28099 C 4375 4375
206 Netherlands 28100 A 4375 4375
207 Netherlands 28101 C 4375 4375
208 Netherlands 28102 C 4375 4375
209 Netherlands 28103 C 4375 4375
210 Netherlands 28104 A 4375 4375
211 Netherlands 28105 T 4375 4375
212 Netherlands 28106 T 4375 4375
213 Netherlands 28107 C 4375 4375
214 Netherlands 28108 A G 4375 4374 Gln72Arg
215 Netherlands 28109 G T 4375 4374 Gln72His
216 Netherlands 28110 T C 4375 4374 Tyr73His
217 Netherlands 28111 A 4375 4375
218 Netherlands 28112 C T 4375 4372 Tyr73Tyr
219 Netherlands 28113 A 4375 4375
220 Netherlands 28114 T 4375 4375
221 Netherlands 28115 C T 4375 4374 Ile74Ile
222 Netherlands 28116 G 4375 4375
223 Netherlands 28117 A T 4375 4351 Asp75Val
224 Netherlands 28118 T 4375 4375
225 Netherlands 28119 A 4375 4375
226 Netherlands 28120 T 4375 4375
227 Netherlands 28121 C 4375 4375
228 Netherlands 28122 G A 4375 4374 Gly77Ser
229 Netherlands 28123 G 4375 4375
230 Netherlands 28124 T 4375 4375
231 Netherlands 28125 A 4375 4375
232 Netherlands 28126 A 4375 4375
233 Netherlands 28127 T 4375 4375
234 Netherlands 28128 T 4376 4376
235 Netherlands 28129 A 4377 4377
236 Netherlands 28130 T 4377 4377
237 Netherlands 28131 A 4377 4377
238 Netherlands 28132 C 4377 4377
239 Netherlands 28133 A T 4377 3951 Thr80Thr
240 Netherlands 28134 G T 4378 4377 Val81Phe
241 Netherlands 28135 T 4378 4378
242 Netherlands 28136 T 4378 4378
243 Netherlands 28137 T 4378 4378
244 Netherlands 28138 C 4378 4378
245 Netherlands 28139 C A 4378 4372 Ser82Ser
246 Netherlands 28140 T 4378 4378
247 Netherlands 28141 G 4378 4378
248 Netherlands 28142 T 4378 4378
249 Netherlands 28143 T 4378 4378
250 Netherlands 28144 T C 4378 4346 Leu84Ser
251 Netherlands 28145 A 4378 4378
252 Netherlands 28146 C T 4378 4377 Pro85Ser
253 Netherlands 28147 C 4378 4378
254 Netherlands 28148 T 4378 4378
255 Netherlands 28149 T 4378 4378
256 Netherlands 28150 T 4378 4378
257 Netherlands 28151 T 4378 4378
258 Netherlands 28152 A 4378 4378
259 Netherlands 28153 C 4378 4378
260 Netherlands 28154 A 4378 4378
261 Netherlands 28155 A 4378 4378
262 Netherlands 28156 T 4378 4378
263 Netherlands 28157 T 4378 4378
264 Netherlands 28158 A 4378 4378
265 Netherlands 28159 A 4378 4378
266 Netherlands 28160 T 4378 4378
267 Netherlands 28161 T 4378 4378
268 Netherlands 28162 G 4378 4378
269 Netherlands 28163 C 4378 4378
270 Netherlands 28164 C 4378 4378
271 Netherlands 28165 A 4378 4378
272 Netherlands 28166 G 4378 4378
273 Netherlands 28167 G 4378 4378
274 Netherlands 28168 A 4378 4378
275 Netherlands 28169 A G 4378 4362 Glu92Glu
276 Netherlands 28170 C A 4378 4373 Pro93Thr
277 Netherlands 28171 C T 4378 4338 Pro93Leu
278 Netherlands 28172 T 4378 4378
279 Netherlands 28173 A 4378 4378
280 Netherlands 28174 A 4378 4378
281 Netherlands 28175 A 4378 4378
282 Netherlands 28176 T 4378 4378
283 Netherlands 28177 T 4377 4377
284 Netherlands 28178 G T 4377 4376 Leu95Phe
285 Netherlands 28179 G 4377 4377
286 Netherlands 28180 G 4377 4377
287 Netherlands 28181 T 4377 4377
288 Netherlands 28182 A 4372 4372
289 Netherlands 28183 G 4372 4372
290 Netherlands 28184 T 4372 4372
291 Netherlands 28185 C 4370 4370
292 Netherlands 28186 T 4370 4370
293 Netherlands 28187 T 4369 4369
294 Netherlands 28188 G 4369 4369
295 Netherlands 28189 T 4369 4369
296 Netherlands 28190 A 4369 4369
297 Netherlands 28191 G 4369 4369
298 Netherlands 28192 T 4369 4369
299 Netherlands 28193 G 4369 4369
300 Netherlands 28194 C 4369 4369
301 Netherlands 28195 G T 4369 4367 Arg101Leu
302 Netherlands 28196 T 4369 4369
303 Netherlands 28197 T 4369 4369
304 Netherlands 28198 G 4369 4369
305 Netherlands 28199 T 4369 4369
306 Netherlands 28200 T 4369 4369
307 Netherlands 28201 C T 4369 4367 Ser103Leu
308 Netherlands 28202 G 4369 4369
309 Netherlands 28203 T 4368 4368
310 Netherlands 28204 T 4366 4366
311 Netherlands 28205 C 4366 4365
312 Netherlands 28206 T 4366 4365
313 Netherlands 28207 A G 4366 4364 Tyr105Cys
314 Netherlands 28208 T 4366 4365
315 Netherlands 28209 G T,A 4366 4361 Glu106*-p.Glu106Lys
316 Netherlands 28210 A 4366 4365
317 Netherlands 28211 A 4366 4365
318 Netherlands 28212 G 4366 4366
319 Netherlands 28213 A 4366 4366
320 Netherlands 28214 C 4366 4366
321 Netherlands 28215 T 4366 4366
322 Netherlands 28216 T 4366 4366
323 Netherlands 28217 T 4366 4366
324 Netherlands 28218 T 4366 4366
325 Netherlands 28219 T 4366 4366
326 Netherlands 28220 A 4366 4366
327 Netherlands 28221 G T 4366 4365 Glu110*
328 Netherlands 28222 A 4366 4366
329 Netherlands 28223 G 4366 4366
330 Netherlands 28224 T 4366 4366
331 Netherlands 28225 A 4366 4366
332 Netherlands 28226 T 4366 4366
333 Netherlands 28227 C 4366 4366
334 Netherlands 28228 A 4367 4367
335 Netherlands 28229 T 4367 4367
336 Netherlands 28230 G 4367 4367
337 Netherlands 28231 A 4367 4367
338 Netherlands 28232 C T 4367 4363 Asp113Asp
339 Netherlands 28233 G A 4367 4365 Val114Ile
340 Netherlands 28234 T 4367 4367
341 Netherlands 28235 T 4367 4367
342 Netherlands 28236 C 4367 4367
343 Netherlands 28237 G A,T 4367 4356 Arg115His-p.Arg115Leu
344 Netherlands 28238 T 4367 4367
345 Netherlands 28239 G 4367 4367
346 Netherlands 28240 T 4367 4367
347 Netherlands 28241 T 4367 4367
348 Netherlands 28242 G 4367 4367
349 Netherlands 28243 T 4367 4367
350 Netherlands 28244 T 4367 4367
351 Netherlands 28245 T 4367 4367
352 Netherlands 28246 T 4367 4367
353 Netherlands 28247 A 4367 4367
354 Netherlands 28248 G 4367 4367
355 Netherlands 28249 A 4367 4367
356 Netherlands 28250 T 4367 4367
357 Netherlands 28251 T 4367 4367
358 Netherlands 28252 T 4367 4367
359 Netherlands 28253 C T 4367 4348 Phe120Phe
360 Netherlands 28254 A T,C 4367 4364 Ile121Phe-p.Ile121Leu
361 Netherlands 28255 T 4367 4367
362 Netherlands 28256 C T 4367 4365 Ile121Ile
363 Netherlands 28257 T 4367 4367
364 Netherlands 28258 A 4367 4367
365 Netherlands 28259 A 4367 4367