National Institute Of Genetic Engineering and Biotechnology

P.I:Mohammad-Ali Malboobi
Here we provide last mutation observed in Nucleocapsid gene of COVID-19 prevalent in Iran.
We kindly wait your comment or coopration in tracking crona virus project.

Amino acid changes

How to read this table:
- Rows are reference amino acids and columns are changed amino acids. E.g. Row 'A' column 'E' indicates how many 'A' amino acids have been replaced by 'E' amino acids.
- Red background colors indicate that more changes happened (heat-map).
- Diagonals are indicated using grey background color
- WARNING: This table may include different translation codon tables (e.g. mamalian DNA and mitochondrial DNA).

  * - ? A C D E F G H I K L M N P Q R S T V Y
*     3                                      
-     370                                      
?                                            
A     27 3                             2   2  
C     18   1     1                           1
D     6     1       1                        
E 2   24 1   1 2         2         1          
F     30         2         2                  
G     12       1   1                 1 1   1  
H     9             2         1             2
I     25         1                     1   2  
K     21                             1        
L 1   45                   4                  
M     6                                   1  
N     6     1                 1              
P     18                   3           4      
Q 1   15             1     1       2          
R     15               3                 1    
S     21 1                       1     1      
T     30 2             6             2        
V     24         2     3   2               1  
Y     15   1                                 3

Nucleotide and amino acid mutations

Here we provide list of mutation observed in Nucleocapsid at gene and protein of COVID-19.
-The position column is nucleotide position in reference genome as NC_045512.2
-The Reference column indicate reference nucleotide in NC_045512.2
-The NS column indicate number of samples that this position have been observed
-The NSR column indicate number of samples with reference nucleotide. Therefore diffrenciate related to Ns indicate number of sample with mutated nucleotide

Contoury Position Reference Alt. NSR NS AAchange
0 Netherlands 27394 A 5883 5883
1 Netherlands 27395 T 5883 5883
2 Netherlands 27396 G 5883 5883
3 Netherlands 27397 A 5883 5883
4 Netherlands 27398 A 5883 5883
5 Netherlands 27399 A 5883 5883
6 Netherlands 27400 A 5883 5883
7 Netherlands 27401 T 5883 5883
8 Netherlands 27402 T 5883 5883
9 Netherlands 27403 A T 5883 5880 Ile4Phe
10 Netherlands 27404 T 5883 5883
11 Netherlands 27405 T 5883 5883
12 Netherlands 27406 C 5883 5883
13 Netherlands 27407 T 5883 5883
14 Netherlands 27408 T 5883 5883
15 Netherlands 27409 T C 5883 5874 Phe6Leu
16 Netherlands 27410 T 5883 5883
17 Netherlands 27411 C 5883 5883
18 Netherlands 27412 T 5883 5883
19 Netherlands 27413 T A 5883 5881 Leu7*
20 Netherlands 27414 G 5883 5883
21 Netherlands 27415 G 5883 5883
22 Netherlands 27416 C T 5883 5882 Ala8Val
23 Netherlands 27417 A G 5883 5881 Ala8Ala
24 Netherlands 27418 C 5883 5883
25 Netherlands 27419 T 5883 5883
26 Netherlands 27420 G 5883 5883
27 Netherlands 27421 A 5883 5883
28 Netherlands 27422 T 5883 5883
29 Netherlands 27423 A 5883 5883
30 Netherlands 27424 A 5883 5883
31 Netherlands 27425 C T,G 5883 5877 Thr11Ile-p.Thr11Arg
32 Netherlands 27426 A 5883 5883
33 Netherlands 27427 C 5883 5883
34 Netherlands 27428 T 5883 5883
35 Netherlands 27429 C 5883 5883
36 Netherlands 27430 G 5883 5883
37 Netherlands 27431 C 5883 5883
38 Netherlands 27432 T 5883 5883
39 Netherlands 27433 A 5883 5883
40 Netherlands 27434 C T 5883 5842 Thr14Ile
41 Netherlands 27435 T 5883 5883
42 Netherlands 27436 T 5883 5883
43 Netherlands 27437 G 5883 5883
44 Netherlands 27438 T 5883 5883
45 Netherlands 27439 G 5883 5883
46 Netherlands 27440 A C 5883 5881 Glu16Ala
47 Netherlands 27441 G 5883 5883
48 Netherlands 27442 C 5883 5883
49 Netherlands 27443 T 5883 5883
50 Netherlands 27444 T 5883 5883
51 Netherlands 27445 T 5883 5883
52 Netherlands 27446 A G 5883 5882 Tyr18Cys
53 Netherlands 27447 T C 5883 5882 Tyr18Tyr
54 Netherlands 27448 C 5883 5883
55 Netherlands 27449 A 5883 5883
56 Netherlands 27450 C 5883 5883
57 Netherlands 27451 T 5883 5883
58 Netherlands 27452 A 5883 5883
59 Netherlands 27453 C 5883 5883
60 Netherlands 27454 C 5883 5883
61 Netherlands 27455 A 5883 5883
62 Netherlands 27456 A 5883 5883
63 Netherlands 27457 G 5883 5883
64 Netherlands 27458 A 5883 5883
65 Netherlands 27459 G A 5883 5882 Glu22Glu
66 Netherlands 27460 T 5883 5883
67 Netherlands 27461 G 5883 5883
68 Netherlands 27462 T 5883 5883
69 Netherlands 27463 G A 5883 5878 Val24Ile
70 Netherlands 27464 T 5883 5883
71 Netherlands 27465 T 5883 5883
72 Netherlands 27466 A 5883 5883
73 Netherlands 27467 G T,C 5883 5881 Arg25Ile-p.Arg25Thr
74 Netherlands 27468 A 5883 5883
75 Netherlands 27469 G 5883 5883
76 Netherlands 27470 G 5883 5883
77 Netherlands 27471 T 5883 5883
78 Netherlands 27472 A G 5883 5875 Thr27Ala
79 Netherlands 27473 C 5883 5883
80 Netherlands 27474 A 5883 5883
81 Netherlands 27475 A 5883 5883
82 Netherlands 27476 C T,G 5883 5880 Thr28Ile-p.Thr28Arg
83 Netherlands 27477 A 5883 5883
84 Netherlands 27478 G T 5883 5882 Val29Leu
85 Netherlands 27479 T 5883 5883
86 Netherlands 27480 A T 5883 5882 Val29Val
87 Netherlands 27481 C 5883 5883
88 Netherlands 27482 T 5883 5883
89 Netherlands 27483 T C 5883 5880 Leu30Leu
90 Netherlands 27484 T C 5883 5880 Leu31Leu
91 Netherlands 27485 T 5883 5883
92 Netherlands 27486 A 5883 5883
93 Netherlands 27487 A 5883 5883
94 Netherlands 27488 A 5883 5883
95 Netherlands 27489 A 5883 5883
96 Netherlands 27490 G A 5883 5882 Glu33Lys
97 Netherlands 27491 A 5883 5883
98 Netherlands 27492 A 5883 5883
99 Netherlands 27493 C T 5883 5879 Pro34Ser
100 Netherlands 27494 C 5883 5883
101 Netherlands 27495 T 5883 5883
102 Netherlands 27496 T 5883 5883
103 Netherlands 27497 G A 5883 5882 Cys35Tyr
104 Netherlands 27498 C 5883 5883
105 Netherlands 27499 T 5872 5872
106 Netherlands 27500 C 5872 5872
107 Netherlands 27501 T 5872 5872
108 Netherlands 27502 T 5872 5872
109 Netherlands 27503 C 5872 5872
110 Netherlands 27504 T C 5872 5871 Ser37Ser
111 Netherlands 27505 G A 5872 5869 Gly38Arg
112 Netherlands 27506 G T,A 5872 5870 Gly38Val-p.Gly38Glu
113 Netherlands 27507 A 5872 5872
114 Netherlands 27508 A 5872 5872
115 Netherlands 27509 C T 5872 5870 Thr39Ile
116 Netherlands 27510 A 5872 5872
117 Netherlands 27511 T 5872 5872
118 Netherlands 27512 A 5872 5872
119 Netherlands 27513 C T 5872 5870 Tyr40Tyr
120 Netherlands 27514 G T,A 5868 5866 Glu41*-p.Glu41Lys
121 Netherlands 27515 A 5868 5868
122 Netherlands 27516 G T 5866 5864 Glu41Asp
123 Netherlands 27517 G A 5866 5865 Gly42Ser
124 Netherlands 27518 G 5866 5866
125 Netherlands 27519 C T 5866 5865 Gly42Gly
126 Netherlands 27520 A G 5866 5865 Asn43Asp
127 Netherlands 27521 A 5859 5859
128 Netherlands 27522 T 5856 5856
129 Netherlands 27523 T 5855 5855
130 Netherlands 27524 C 5855 5855
131 Netherlands 27525 A 5854 5854
132 Netherlands 27526 C 5854 5854
133 Netherlands 27527 C T 5854 5853 Pro45Leu
134 Netherlands 27528 A 5854 5854
135 Netherlands 27529 T 5854 5854
136 Netherlands 27530 T 5854 5854
137 Netherlands 27531 T 5854 5854
138 Netherlands 27532 C T,A 5854 5847 His47Tyr-p.His47Asn
139 Netherlands 27533 A 5854 5854
140 Netherlands 27534 T C 5854 5853 His47His
141 Netherlands 27535 C 5854 5854
142 Netherlands 27536 C 5854 5854
143 Netherlands 27537 T 5854 5854
144 Netherlands 27538 C 5854 5854
145 Netherlands 27539 T 5854 5854
146 Netherlands 27540 A 5854 5854
147 Netherlands 27541 G 5852 5852
148 Netherlands 27542 C 5852 5852
149 Netherlands 27543 T 5852 5852
150 Netherlands 27544 G 5852 5852
151 Netherlands 27545 A 5852 5852
152 Netherlands 27546 T 5852 5852
153 Netherlands 27547 A 5852 5852
154 Netherlands 27548 A 5852 5852
155 Netherlands 27549 C T 5852 5845 Asn52Asn
156 Netherlands 27550 A 5852 5852
157 Netherlands 27551 A 5852 5852
158 Netherlands 27552 A 5852 5852
159 Netherlands 27553 T 5852 5852
160 Netherlands 27554 T 5852 5852
161 Netherlands 27555 T 5852 5852
162 Netherlands 27556 G T 5852 5849 Ala55Ser
163 Netherlands 27557 C 5852 5852
164 Netherlands 27558 A 5852 5852
165 Netherlands 27559 C 5852 5852
166 Netherlands 27560 T 5852 5852
167 Netherlands 27561 G 5852 5852
168 Netherlands 27562 A 5852 5852
169 Netherlands 27563 C 5852 5852
170 Netherlands 27564 T 5852 5852
171 Netherlands 27565 T 5852 5852
172 Netherlands 27566 G 5852 5852
173 Netherlands 27567 C 5852 5852
174 Netherlands 27568 T 5852 5852
175 Netherlands 27569 T 5852 5852
176 Netherlands 27570 T 5852 5852
177 Netherlands 27571 A 5852 5852
178 Netherlands 27572 G 5852 5852
179 Netherlands 27573 C 5852 5852
180 Netherlands 27574 A 5840 5840
181 Netherlands 27575 C 5840 5840
182 Netherlands 27576 T 5840 5840
183 Netherlands 27577 C 5840 5840
184 Netherlands 27578 A 5840 5840
185 Netherlands 27579 A 5840 5840
186 Netherlands 27580 T 5840 5840
187 Netherlands 27581 T 5840 5840
188 Netherlands 27582 T 5840 5840
189 Netherlands 27583 G T 5840 5839 Ala64Ser
190 Netherlands 27584 C 5840 5840
191 Netherlands 27585 T 5840 5840
192 Netherlands 27586 T C 5840 5839 Phe65Leu
193 Netherlands 27587 T 5840 5840
194 Netherlands 27588 T 5840 5840
195 Netherlands 27589 G 5840 5840
196 Netherlands 27590 C 5840 5840
197 Netherlands 27591 T 5840 5840
198 Netherlands 27592 T 5840 5840
199 Netherlands 27593 G T 5840 5839 Cys67Phe
200 Netherlands 27594 T C 5840 5839 Cys67Cys
201 Netherlands 27595 C T 5840 5839 Pro68Ser
202 Netherlands 27596 C 5840 5840
203 Netherlands 27597 T 5840 5840
204 Netherlands 27598 G C 5840 5839 Asp69His
205 Netherlands 27599 A 5840 5840
206 Netherlands 27600 C T 5840 5827 Asp69Asp
207 Netherlands 27601 G 5840 5840
208 Netherlands 27602 G 5840 5840
209 Netherlands 27603 C 5840 5840
210 Netherlands 27604 G T 5840 5836 Val71Leu
211 Netherlands 27605 T 5840 5839
212 Netherlands 27606 A 5840 5840
213 Netherlands 27607 A 5840 5840
214 Netherlands 27608 A G 5840 5837 Lys72Arg
215 Netherlands 27609 A 5840 5840
216 Netherlands 27610 C T 5840 5838 His73Tyr
217 Netherlands 27611 A 5840 5840
218 Netherlands 27612 C T 5840 5704 His73His
219 Netherlands 27613 G A 5840 5839 Val74Ile
220 Netherlands 27614 T 5840 5840
221 Netherlands 27615 C 5840 5840
222 Netherlands 27616 T 5840 5840
223 Netherlands 27617 A 5840 5840
224 Netherlands 27618 T C 5840 5839 Tyr75Tyr
225 Netherlands 27619 C 5840 5840
226 Netherlands 27620 A 5840 5840
227 Netherlands 27621 G A,T 5840 5831 Gln76His-p.Gln76Gln
228 Netherlands 27622 T 5840 5840
229 Netherlands 27623 T 5840 5840
230 Netherlands 27624 A 5840 5840
231 Netherlands 27625 C 5840 5840
232 Netherlands 27626 G 5840 5840
233 Netherlands 27627 T 5840 5840
234 Netherlands 27628 G 5840 5840
235 Netherlands 27629 C 5840 5840
236 Netherlands 27630 C T 5840 5839 Ala79Ala
237 Netherlands 27631 A 5840 5840
238 Netherlands 27632 G T 5840 5814 Arg80Ile
239 Netherlands 27633 A 5840 5840
240 Netherlands 27634 T 5854 5854
241 Netherlands 27635 C 5854 5854
242 Netherlands 27636 A 5854 5854
243 Netherlands 27637 G 5854 5854
244 Netherlands 27638 T 5854 5854
245 Netherlands 27639 T 5854 5854
246 Netherlands 27640 T G 5854 5853 Ser83Ala
247 Netherlands 27641 C 5854 5854
248 Netherlands 27642 A 5854 5854
249 Netherlands 27643 C T 5854 5852 Pro84Ser
250 Netherlands 27644 C T 5854 5852 Pro84Leu
251 Netherlands 27645 T 5854 5854
252 Netherlands 27646 A 5854 5854
253 Netherlands 27647 A 5854 5854
254 Netherlands 27648 A 5854 5854
255 Netherlands 27649 C 5854 5854
256 Netherlands 27650 T 5854 5854
257 Netherlands 27651 G T 5854 5843 Leu86Leu
258 Netherlands 27652 T 5854 5854
259 Netherlands 27653 T 5854 5854
260 Netherlands 27654 C T 5854 5736 Phe87Phe
261 Netherlands 27655 A G 5854 5851 Ile88Val
262 Netherlands 27656 T G 5854 5852 Ile88Ser
263 Netherlands 27657 C 5854 5854
264 Netherlands 27658 A 5854 5854
265 Netherlands 27659 G 5854 5854
266 Netherlands 27660 A 5854 5854
267 Netherlands 27661 C 5854 5854
268 Netherlands 27662 A 5854 5854
269 Netherlands 27663 A G 5854 5853 Gln90Gln
270 Netherlands 27664 G 5854 5854
271 Netherlands 27665 A 5854 5854
272 Netherlands 27666 G 5854 5854
273 Netherlands 27667 G 5854 5854
274 Netherlands 27668 A 5854 5854
275 Netherlands 27669 A 5854 5854
276 Netherlands 27670 G T 5854 5844 Val93Phe
277 Netherlands 27671 T 5854 5854
278 Netherlands 27672 T 5854 5854
279 Netherlands 27673 C T 5854 5851 Gln94*
280 Netherlands 27674 A T 5854 5832 Gln94Leu
281 Netherlands 27675 A 5854 5854
282 Netherlands 27676 G C 5854 5850 Glu95Gln
283 Netherlands 27677 A 5854 5854
284 Netherlands 27678 A 5854 5854
285 Netherlands 27679 C 5854 5854
286 Netherlands 27680 T 5854 5854
287 Netherlands 27681 T 5854 5854
288 Netherlands 27682 T 5854 5854
289 Netherlands 27683 A 5855 5855
290 Netherlands 27684 C 5855 5855
291 Netherlands 27685 T C 5855 5853 Ser98Pro
292 Netherlands 27686 C 5855 5855
293 Netherlands 27687 T 5855 5855
294 Netherlands 27688 C T 5855 5852 Pro99Ser
295 Netherlands 27689 C T 5855 5854 Pro99Leu
296 Netherlands 27690 A 5855 5855
297 Netherlands 27691 A G 5855 5854 Ile100Val
298 Netherlands 27692 T 5855 5855
299 Netherlands 27693 T 5855 5855
300 Netherlands 27694 T 5826 5826
301 Netherlands 27695 T 5826 5826
302 Netherlands 27696 T 5826 5826
303 Netherlands 27697 C 5826 5826
304 Netherlands 27698 T 5826 5826
305 Netherlands 27699 T 5826 5826
306 Netherlands 27700 A 5826 5826
307 Netherlands 27701 T 5826 5826
308 Netherlands 27702 T 5826 5826
309 Netherlands 27703 G A,T 5826 5823 Val104Ile-p.Val104Phe
310 Netherlands 27704 T 5826 5826
311 Netherlands 27705 T 5826 5826
312 Netherlands 27706 G 5826 5826
313 Netherlands 27707 C T 5826 5808 Ala105Val
314 Netherlands 27708 G 5826 5826
315 Netherlands 27709 G 5826 5826
316 Netherlands 27710 C 5826 5826
317 Netherlands 27711 A G 5826 5825 Ala106Ala
318 Netherlands 27712 A 5826 5826
319 Netherlands 27713 T 5826 5826
320 Netherlands 27714 A 5826 5826
321 Netherlands 27715 G 5826 5826
322 Netherlands 27716 T 5826 5826
323 Netherlands 27717 G 5826 5826
324 Netherlands 27718 T 5826 5826
325 Netherlands 27719 T 5826 5826
326 Netherlands 27720 T 5826 5826
327 Netherlands 27721 A 5827 5827
328 Netherlands 27722 T 5827 5827
329 Netherlands 27723 A 5827 5827
330 Netherlands 27724 A 5827 5827
331 Netherlands 27725 C 5827 5827
332 Netherlands 27726 A 5827 5827
333 Netherlands 27727 C 5827 5827
334 Netherlands 27728 T 5827 5827
335 Netherlands 27729 T 5827 5827
336 Netherlands 27730 T 5827 5827
337 Netherlands 27731 G 5827 5827
338 Netherlands 27732 C 5826 5826
339 Netherlands 27733 T 5826 5826
340 Netherlands 27734 T 5826 5826
341 Netherlands 27735 C T 5826 5823 Phe114Phe
342 Netherlands 27736 A 5826 5826
343 Netherlands 27737 C T 5826 5825 Thr115Ile
344 Netherlands 27738 A 5826 5826
345 Netherlands 27739 C 5826 5826
346 Netherlands 27740 T 5826 5826
347 Netherlands 27741 C T 5826 5820 Leu116Leu
348 Netherlands 27742 A 5826 5826
349 Netherlands 27743 A 5826 5826
350 Netherlands 27744 A 5826 5826
351 Netherlands 27745 A 5826 5826
352 Netherlands 27746 G T 5826 5825 Arg118Ile
353 Netherlands 27747 A 5826 5826
354 Netherlands 27748 A 5826 5826
355 Netherlands 27749 A 5826 5826
356 Netherlands 27750 G 5826 5826
357 Netherlands 27751 A G 5826 5825 Thr120Ala
358 Netherlands 27752 C T 5826 5808 Thr120Ile
359 Netherlands 27753 A 5826 5826
360 Netherlands 27754 G T 5826 5824 Glu121*
361 Netherlands 27755 A 5826 5826
362 Netherlands 27756 A G 5826 5820 -p.Met1?
363 Netherlands 27757 T 5826 5826
364 Netherlands 27758 G 5826 5826
365 Netherlands 27759 A 5826 5826