National Institute Of Genetic Engineering and Biotechnology

P.I:Mohammad-Ali Malboobi
Here we provide last mutation observed in Nucleocapsid gene of COVID-19 prevalent in Iran.
We kindly wait your comment or coopration in tracking crona virus project.

Amino acid changes

How to read this table:
- Rows are reference amino acids and columns are changed amino acids. E.g. Row 'A' column 'E' indicates how many 'A' amino acids have been replaced by 'E' amino acids.
- Red background colors indicate that more changes happened (heat-map).
- Diagonals are indicated using grey background color
- WARNING: This table may include different translation codon tables (e.g. mamalian DNA and mitochondrial DNA).

  * - ? A C D E F G H I K L M N P Q R S T V Y
*     3                             1        
-     362                                      
?                                            
A     26 5     1   1                   8 3 5  
C     18   4     3                     2     2
D     6     2     1           1             1
E 5   23     3 6   5     2         2       2  
F     30         6         8               1  
G     11 1 2   1   2                 1 1   2  
H     9             2                       2
I     25         3     3     1 1         6 6  
K     21               1 1     4     1   1    
L     44         8     2   17     4 2 2 1   1  
M     6               2                 1 1  
N     6                       1       1      
P     18             2     4     2     6      
Q 5   15             3   1 3       1 2        
R     13   1         1 4 1 1     1   1 1 2    
S     20   1     2     1   3   1 3     7 2   1
T     30 3             7               2 6    
V     23 2       5     2   4 1             5  
Y     15   2         3         1             4

Nucleotide and amino acid mutations

Here we provide list of mutation observed in Nucleocapsid at gene and protein of COVID-19.
-The position column is nucleotide position in reference genome as NC_045512.2
-The Reference column indicate reference nucleotide in NC_045512.2
-The NS column indicate number of samples that this position have been observed
-The NSR column indicate number of samples with reference nucleotide. Therefore diffrenciate related to Ns indicate number of sample with mutated nucleotide

Contoury Position Reference Alt. NSR NS AAchange
0 England 27394 A 50850 50850
1 England 27395 T 50850 50850
2 England 27396 G T,A 50850 50846 Met1?-p.Met1?
3 England 27397 A 50851 50850
4 England 27398 A G 50851 50850 Lys2Arg
5 England 27399 A C 50852 50847 Lys2Asn
6 England 27400 A G 50853 50835 Ile3Val
7 England 27401 T C 50853 50846 Ile3Thr
8 England 27402 T C 50854 50849 Ile3Ile
9 England 27403 A T,G 50854 50847 Ile4Phe-p.Ile4Val
10 England 27404 T A 50855 50849 Ile4Asn
11 England 27405 T C 50855 50851 Ile4Ile
12 England 27406 C T 50855 50839 Leu5Phe
13 England 27407 T C 50855 50851 Leu5Pro
14 England 27408 T C 50857 50853 Leu5Leu
15 England 27409 T C 50857 50838 Phe6Leu
16 England 27410 T 50857 50856
17 England 27411 C T,A 50857 50851 Phe6Leu-p.Phe6Phe
18 England 27412 T 50857 50857
19 England 27413 T 50857 50857
20 England 27414 G T,A 50857 50853 Leu7Phe-p.Leu7Leu
21 England 27415 G A,T 50857 50717 Ala8Thr-p.Ala8Ser
22 England 27416 C T 50857 50854 Ala8Val
23 England 27417 A G 50857 50854 Ala8Ala
24 England 27418 C T 50857 50855 Leu9Leu
25 England 27419 T A 50857 50856 Leu9Gln
26 England 27420 G A 50858 50848 Leu9Leu
27 England 27421 A G 50859 50856 Ile10Val
28 England 27422 T C 50859 50854 Ile10Thr
29 England 27423 A 50859 50859
30 England 27424 A G 50859 50857 Thr11Ala
31 England 27425 C T 50859 50842 Thr11Ile
32 England 27426 A T 50859 50858 Thr11Thr
33 England 27427 C T 50859 50857 Leu12Phe
34 England 27428 T C,G 50859 50853 Leu12Pro-p.Leu12Arg
35 England 27429 C T 50859 50855 Leu12Leu
36 England 27430 G A,T 50860 50853 Ala13Thr-p.Ala13Ser
37 England 27431 C T 50860 50858 Ala13Val
38 England 27432 T C 50860 50858 Ala13Ala
39 England 27433 A G 50860 50859 Thr14Ala
40 England 27434 C T 50860 50830 Thr14Ile
41 England 27435 T 50860 50860
42 England 27436 T 50860 50859
43 England 27437 G A,T 50860 50854 Cys15Tyr-p.Cys15Phe
44 England 27438 T C 50860 50858 Cys15Cys
45 England 27439 G T 50860 50854 Glu16*
46 England 27440 A G 50860 50855 Glu16Gly
47 England 27441 G T 50860 50828 Glu16Asp
48 England 27442 C T,A 50861 50819 Leu17Phe-p.Leu17Ile
49 England 27443 T 50861 50855
50 England 27444 T 50861 50859
51 England 27445 T 50861 50858
52 England 27446 A 50861 50858
53 England 27447 T C 50865 50860 Tyr18Tyr
54 England 27448 C 50865 50863
55 England 27449 A 50865 50864
56 England 27450 C T 50865 50861 His19His
57 England 27451 T A,C 50864 50851 Tyr20Asn-p.Tyr20His
58 England 27452 A G 50868 50864 Tyr20Cys
59 England 27453 C 50868 50865
60 England 27454 C T 50876 50874 Gln21*
61 England 27455 A G 50876 50820 Gln21Arg
62 England 27456 A 50878 50876
63 England 27457 G 50879 50878
64 England 27458 A 50879 50876
65 England 27459 G T 50879 50861 Glu22Asp
66 England 27460 T 50879 50877
67 England 27461 G T 50881 50869 Cys23Phe
68 England 27462 T C 50882 50876 Cys23Cys
69 England 27463 G T,C,A 50883 50864 Val24Leu-p.Val24Ile
70 England 27464 T 50884 50880
71 England 27465 T 50884 50882
72 England 27466 A 50883 50880
73 England 27467 G T,C 50883 50821 Arg25Ile-p.Arg25Thr
74 England 27468 A 50883 50879
75 England 27469 G A,C 50883 50874 Gly26Ser-p.Gly26Arg
76 England 27470 G 50883 50879
77 England 27471 T 50881 50877
78 England 27472 A G 50915 50907 Thr27Ala
79 England 27473 C 50915 50911
80 England 27474 A 50915 50911
81 England 27475 A 50915 50912
82 England 27476 C T 50915 50876 Thr28Ile
83 England 27477 A 50915 50909
84 England 27478 G T 50915 50898 Val29Leu
85 England 27479 T C 50915 50909 Val29Ala
86 England 27480 A 50915 50911
87 England 27481 C T 50916 50912 Leu30Phe
88 England 27482 T 50916 50910
89 England 27483 T 50916 50912
90 England 27484 T C 50916 50905 Leu31Leu
91 England 27485 T 50921 50916
92 England 27486 A 50921 50916
93 England 27487 A 50921 50917
94 England 27488 A T 50921 50902 Lys32Ile
95 England 27489 A 50921 50917
96 England 27490 G 50921 50918
97 England 27491 A G 50921 50914 Glu33Gly
98 England 27492 A G 50921 50916 Glu33Glu
99 England 27493 C T 50922 50906 Pro34Ser
100 England 27494 C T 50922 50904 Pro34Leu
101 England 27495 T C 50922 50915 Pro34Pro
102 England 27496 T 50922 50917
103 England 27497 G T,A 50922 50905 Cys35Phe-p.Cys35Tyr
104 England 27498 C T 50922 50914 Cys35Cys
105 England 27499 T C 50922 50911 Ser36Pro
106 England 27500 C 50922 50917
107 England 27501 T G 50922 50904 Ser36Ser
108 England 27502 T A 50922 50901 Ser37Thr
109 England 27503 C T,A 50922 50903 Ser37Phe-p.Ser37Tyr
110 England 27504 T C 50922 50914 Ser37Ser
111 England 27505 G 50922 50916
112 England 27506 G T,C,A 50922 50888 Gly38Ala-p.Gly38Glu
113 England 27507 A T 50922 50915 Gly38Gly
114 England 27508 A 50922 50916
115 England 27509 C T 50921 50869 Thr39Ile
116 England 27510 A G 50919 50908 Thr39Thr
117 England 27511 T 50917 50908
118 England 27512 A 48040 47943
119 England 27513 C T 48032 47674 Tyr40Tyr
120 England 27514 G T,A 47991 47884 Glu41*-p.Glu41Lys
121 England 27515 A T,G 47980 47882 Glu41Val-p.Glu41Gly
122 England 27516 G T,A 47980 47862 Glu41Asp-p.Glu41Glu
123 England 27517 G T 47977 47882 Gly42Cys
124 England 27518 G 47972 47882
125 England 27519 C 47907 47820
126 England 27520 A 47841 47747
127 England 27521 A 47833 47736
128 England 27522 T 47825 47725
129 England 27523 T 47817 47724
130 England 27524 C T 47787 47678 Ser44Leu
131 England 27525 A 47521 47424
132 England 27526 C T 47492 47390 Pro45Ser
133 England 27527 C T 46608 46441 Pro45Leu
134 England 27528 A 45418 45142
135 England 27529 T 45399 45132
136 England 27530 T 45397 45139
137 England 27531 T C 45391 45135 Phe46Phe
138 England 27532 C T 45382 45064 His47Tyr
139 England 27533 A 45320 45064
140 England 27534 T C 44521 44336 His47His
141 England 27535 C T 44511 44335 Pro48Ser
142 England 27536 C A 44507 44344 Pro48His
143 England 27537 T 44485 44303
144 England 27538 C A,T 44482 44297 Leu49Ile-p.Leu49Leu
145 England 27539 T C 44480 44296 Leu49Pro
146 England 27540 A G 44479 44315 Leu49Leu
147 England 27541 G 44475 44311
148 England 27542 C T 44471 44239 Ala50Val
149 England 27543 T 44468 44305
150 England 27544 G 44467 44307
151 England 27545 A G 44452 44274 Asp51Gly
152 England 27546 T C 44451 44281 Asp51Asp
153 England 27547 A 44450 44287
154 England 27548 A G 44448 44290 Asn52Ser
155 England 27549 C T 44445 44284 Asn52Asn
156 England 27550 A 44443 44275
157 England 27551 A C 44440 44300 Lys53Thr
158 England 27552 A 44438 44303
159 England 27553 T C 44433 44291 Phe54Leu
160 England 27554 T 44428 44281
161 England 27555 T C,A 44421 44266 Phe54Leu-p.Phe54Phe
162 England 27556 G T,A 44409 44243 Ala55Ser-p.Ala55Thr
163 England 27557 C A,T,G 44396 44229 Ala55Val-p.Ala55Gly
164 England 27558 A 44392 44232
165 England 27559 C T 44385 44206 Leu56Leu
166 England 27560 T A 44383 44212 Leu56Gln
167 England 27561 G T,A 44378 44222 Leu56Leu-p.Leu56Leu
168 England 27562 A T 44375 44248 Thr57Ser
169 England 27563 C 44372 44252
170 England 27564 T 44370 44245
171 England 27565 T 44369 44255
172 England 27566 G 44364 44272
173 England 27567 C T 44360 44264 Cys58Cys
174 England 27568 T 44360 44267
175 England 27569 T 44360 44272
176 England 27570 T C 44357 44263 Phe59Phe
177 England 27571 A 44351 44250
178 England 27572 G T,C,A 44351 44245 Ser60Thr-p.Ser60Asn
179 England 27573 C 44350 44259
180 England 27574 A 44312 44220
181 England 27575 C T,G 44311 44225 Thr61Ile-p.Thr61Ser
182 England 27576 T G,C 44312 44210 Thr61Thr-p.Thr61Thr
183 England 27577 C T 44314 44211 Gln62*
184 England 27578 A T 44313 44236 Gln62Leu
185 England 27579 A T 44306 44245 Gln62His
186 England 27580 T C 44299 44221 Phe63Leu
187 England 27581 T 44297 44234
188 England 27582 T 44292 44229
189 England 27583 G T 44291 44224 Ala64Ser
190 England 27584 C 44287 44235
191 England 27585 T 44287 44194
192 England 27586 T 44286 44222
193 England 27587 T 44288 44237
194 England 27588 T 44292 44244
195 England 27589 G T 44296 44243 Ala66Ser
196 England 27590 C 44296 44243
197 England 27591 T 44296 44244
198 England 27592 T A 44293 44239 Cys67Ser
199 England 27593 G 44298 44239
200 England 27594 T 44298 44247
201 England 27595 C T 44301 44217 Pro68Ser
202 England 27596 C 44297 44244
203 England 27597 T C 44292 44232 Pro68Pro
204 England 27598 G T,A 44295 44234 Asp69Tyr-p.Asp69Asn
205 England 27599 A 44294 44238
206 England 27600 C T 44287 44176 Asp69Asp
207 England 27601 G T 44286 44213 Gly70Cys
208 England 27602 G T 44285 44210 Gly70Val
209 England 27603 C T 44286 44211 Gly70Gly
210 England 27604 G A 44309 44256 Val71Ile
211 England 27605 T 44308 44248
212 England 27606 A 44342 44275
213 England 27607 A 44352 44303
214 England 27608 A 44349 44295
215 England 27609 A C 44354 44222 Lys72Asn
216 England 27610 C T 44334 44217 His73Tyr
217 England 27611 A 44327 44237
218 England 27612 C 44314 44211
219 England 27613 G T 44316 44214 Val74Phe
220 England 27614 T 44313 44212
221 England 27615 C T 44310 44210 Val74Val
222 England 27616 T C 44308 44215 Tyr75His
223 England 27617 A G 44309 44213 Tyr75Cys
224 England 27618 T C 44303 44204 Tyr75Tyr
225 England 27619 C T 44286 44134 Gln76*
226 England 27620 A G 44285 44125 Gln76Arg
227 England 27621 G T 44280 44112 Gln76His
228 England 27622 T C 44277 44113 Leu77Leu
229 England 27623 T C 44278 44124 Leu77Ser
230 England 27624 A 44272 44104
231 England 27625 C T 44266 44079 Arg78Cys
232 England 27626 G C,T,A 44266 44074 Arg78Leu-p.Arg78His
233 England 27627 T 44262 44102
234 England 27628 G T 44261 44096 Ala79Ser
235 England 27629 C 44258 44082
236 England 27630 C T 44253 44037 Ala79Ala
237 England 27631 A 44253 44069
238 England 27632 G T 44254 43913 Arg80Ile
239 England 27633 A 44252 44068
240 England 27634 T C 44310 44110 Ser81Pro
241 England 27635 C T 44362 44167 Ser81Leu
242 England 27636 A T,G 44356 44142 Ser81Ser-p.Ser81Ser
243 England 27637 G T 44356 44177 Val82Phe
244 England 27638 T 44357 44203
245 England 27639 T C 44358 44224 Val82Val
246 England 27640 T 44357 44229
247 England 27641 C T 44353 44191 Ser83Leu
248 England 27642 A G 44352 44236 Ser83Ser
249 England 27643 C T 44350 44220 Pro84Ser
250 England 27644 C T,A 44349 44220 Pro84Leu-p.Pro84His
251 England 27645 T 44347 44227
252 England 27646 A 44343 44218
253 England 27647 A 44339 44212
254 England 27648 A G 44338 44194 Lys85Lys
255 England 27649 C T 44335 44170 Leu86Leu
256 England 27650 T 44332 44149
257 England 27651 G C,A,T 44332 44210 Leu86Leu-p.Leu86Leu
258 England 27652 T C 44331 44232 Phe87Leu
259 England 27653 T 44331 44237
260 England 27654 C T,G 44331 44233 Phe87Leu-p.Phe87Phe
261 England 27655 A G,T 44330 44245 Ile88Val-p.Ile88Phe
262 England 27656 T C 44328 44243 Ile88Thr
263 England 27657 C T 44327 44219 Ile88Ile
264 England 27658 A 44326 44224
265 England 27659 G T,C,A 44325 44211 Arg89Thr-p.Arg89Lys
266 England 27660 A G,T 44324 44228 Arg89Ser-p.Arg89Arg
267 England 27661 C T 44322 44204 Gln90*
268 England 27662 A T 44322 44247 Gln90Leu
269 England 27663 A 44321 44247
270 England 27664 G 44322 44246
271 England 27665 A G 44322 44263 Glu91Gly
272 England 27666 G A 44321 44259 Glu91Glu
273 England 27667 G T 44320 44252 Glu92*
274 England 27668 A 44296 44207
275 England 27669 A G 44295 44006 Glu92Glu
276 England 27670 G T,C 44295 44197 Val93Phe-p.Val93Leu
277 England 27671 T C 44295 44215 Val93Ala
278 England 27672 T C 44294 44218 Val93Val
279 England 27673 C T,A 44291 44193 Gln94*-p.Gln94Lys
280 England 27674 A T 44288 44210 Gln94Leu
281 England 27675 A C,G 44286 44208 Gln94His-p.Gln94Gln
282 England 27676 G C,T 44284 44208 Glu95*-p.Glu95Gln
283 England 27677 A 44284 44225
284 England 27678 A G 44282 44220 Glu95Glu
285 England 27679 C T 44275 44086 Leu96Phe
286 England 27680 T G 44273 44179 Leu96Arg
287 England 27681 T 44272 44196
288 England 27682 T C 44269 44194 Tyr97His
289 England 27683 A 44263 44188
290 England 27684 C T 44262 44150 Tyr97Tyr
291 England 27685 T C 44260 44170 Ser98Pro
292 England 27686 C T,G 44257 44179 Ser98Phe-p.Ser98Cys
293 England 27687 T G,C 44256 44188 Ser98Ser-p.Ser98Ser
294 England 27688 C T 44254 44131 Pro99Ser
295 England 27689 C T 44254 44191 Pro99Leu
296 England 27690 A 44253 44205
297 England 27691 A T 44253 44201 Ile100Phe
298 England 27692 T C 44253 44170 Ile100Thr
299 England 27693 T 44255 44212
300 England 27694 T 44255 44210
301 England 27695 T 44254 44203
302 England 27696 T 44253 44201
303 England 27697 C T,G 44240 44189 Leu102Phe-p.Leu102Val
304 England 27698 T 44233 44193
305 England 27699 T 44231 44193
306 England 27700 A G 44227 44193 Ile103Val
307 England 27701 T 44224 44192
308 England 27702 T G 44223 44187 Ile103Met
309 England 27703 G T 44208 44134 Val104Phe
310 England 27704 T 44206 44172
311 England 27705 T C 44204 44178 Val104Val
312 England 27706 G T 44203 44152 Ala105Ser
313 England 27707 C T 44203 44174 Ala105Val
314 England 27708 G A,T 44202 44172 Ala105Ala-p.Ala105Ala
315 England 27709 G T 44203 44178 Ala106Ser
316 England 27710 C 44200 44178
317 England 27711 A 44199 44178
318 England 27712 A 44197 44176
319 England 27713 T C 44196 44173 Ile107Thr
320 England 27714 A 44194 44174
321 England 27715 G T,A 44193 44156 Val108Leu-p.Val108Met
322 England 27716 T 44188 44166
323 England 27717 G A 44188 44174 Val108Val
324 England 27718 T 44183 44158
325 England 27719 T 44183 44171
326 England 27720 T C 44183 44170 Phe109Phe
327 England 27721 A G 44183 44170 Ile110Val
328 England 27722 T C 44184 44173 Ile110Thr
329 England 27723 A 44182 44173
330 England 27724 A 44181 44175
331 England 27725 C 44179 44173
332 England 27726 A 44169 44157
333 England 27727 C 44164 44159
334 England 27728 T 44146 44122
335 England 27729 T 44146 44140
336 England 27730 T A 44144 44136 Cys113Ser
337 England 27731 G 44143 44137
338 England 27732 C 44140 44133
339 England 27733 T C,G 44137 44123 Phe114Leu-p.Phe114Val
340 England 27734 T 44137 44131
341 England 27735 C 44135 44123
342 England 27736 A 44130 44116
343 England 27737 C T 44129 44114 Thr115Ile
344 England 27738 A C 44120 44096 Thr115Thr
345 England 27739 C T 44120 44093 Leu116Phe
346 England 27740 T C 44116 44108 Leu116Pro
347 England 27741 C T 44112 44075 Leu116Leu
348 England 27742 A 44108 44054
349 England 27743 A 44105 44093
350 England 27744 A 44103 44100
351 England 27745 A 44100 44094
352 England 27746 G T 44097 44073 Arg118Ile
353 England 27747 A 44096 44091
354 England 27748 A 44088 44083
355 England 27749 A 44084 44082
356 England 27750 G T,C 44078 44043 Lys119Asn-p.Lys119Asn
357 England 27751 A 44075 44073
358 England 27752 C T 44073 44048 Thr120Ile
359 England 27753 A T 44055 44053 Thr120Thr
360 England 27754 G T,A,C 44054 44031 Glu121Lys-p.Glu121Gln
361 England 27755 A T,G 44051 44045 Glu121Val-p.Glu121Gly
362 England 27756 A G 44046 44042 -p.Met1?
363 England 27757 T C 44040 44039 -p.Ter122Argext*?
364 England 27758 G 44036 44034
365 England 27759 A 44023 44023