National Institute Of Genetic Engineering and Biotechnology

P.I:Mohammad-Ali Malboobi
Here we provide last mutation observed in Nucleocapsid gene of COVID-19 prevalent in Iran.
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Amino acid changes

How to read this table:
- Rows are reference amino acids and columns are changed amino acids. E.g. Row 'A' column 'E' indicates how many 'A' amino acids have been replaced by 'E' amino acids.
- Red background colors indicate that more changes happened (heat-map).
- Diagonals are indicated using grey background color
- WARNING: This table may include different translation codon tables (e.g. mamalian DNA and mitochondrial DNA).

  * - ? A C D F G H I K L M N P Q R S T V Y
*     2                         1          
-     116                                    
?                                          
A     6 1                               2  
C     3   1                                
D     3                                   1
F     12   1   1         1                  
G     3                                    
H                                          
I     9                   1             1  
K                                          
L     12       1                            
M     6             1                      
N     16     1         1     2       1     1
P     3                 1     1     1      
Q 1   3                                    
R     6   1       1 1   1         1   1    
S     6       1 1                          
T     6 1                 1           1    
V     11             1   3               1  
Y     9   1                               1

Nucleotide and amino acid mutations

Here we provide list of mutation observed in Nucleocapsid at gene and protein of COVID-19.
-The position column is nucleotide position in reference genome as NC_045512.2
-The Reference column indicate reference nucleotide in NC_045512.2
-The NS column indicate number of samples that this position have been observed
-The NSR column indicate number of samples with reference nucleotide. Therefore diffrenciate related to Ns indicate number of sample with mutated nucleotide
Contoury Position Reference Alt. NSR NS AAchange
0 Japan 29558 A 17017 17017
1 Japan 29559 T 17017 17017
2 Japan 29560 G 17017 17017
3 Japan 29561 G 17017 17017
4 Japan 29562 G 17017 17017
5 Japan 29563 C 17017 17017
6 Japan 29564 T 17017 17017
7 Japan 29565 A 17017 17017
8 Japan 29566 T 17017 17017
9 Japan 29567 A G 17017 17014 Ile4Val
10 Japan 29568 T 17017 17017
11 Japan 29569 A 17017 17017
12 Japan 29570 A 17017 17017
13 Japan 29571 A 17017 17017
14 Japan 29572 C 17017 17017
15 Japan 29573 G 17017 17017
16 Japan 29574 T 17017 17017
17 Japan 29575 T C 17017 17016 Val6Val
18 Japan 29576 T 17017 17017
19 Japan 29577 T G 17017 17016 Phe7Cys
20 Japan 29578 C T 17017 17015 Phe7Phe
21 Japan 29579 G 17017 17017
22 Japan 29580 C T 17017 17015 Ala8Val
23 Japan 29581 T C 17017 17016 Ala8Ala
24 Japan 29582 T C 17017 17015 Phe9Leu
25 Japan 29583 T 17017 17017
26 Japan 29584 T 17017 17017
27 Japan 29585 C T 17017 17013 Pro10Ser
28 Japan 29586 C T 17017 17016 Pro10Leu
29 Japan 29587 G T 17017 17016 Pro10Pro
30 Japan 29588 T 17017 17017
31 Japan 29589 T 17017 17017
32 Japan 29590 T 17017 17017
33 Japan 29591 A 17017 17017
34 Japan 29592 C T 17017 17016 Thr12Met
35 Japan 29593 G T 17016 17015 Thr12Thr
36 Japan 29594 A 17016 17016
37 Japan 29595 T 17015 17015
38 Japan 29596 A G 17015 17013 Ile13Met
39 Japan 29597 T 17015 17015
40 Japan 29598 A G 17015 17014 Tyr14Cys
41 Japan 29599 T 17015 17015
42 Japan 29600 A G 17015 17014 Ser15Gly
43 Japan 29601 G 17015 17015
44 Japan 29602 T 17015 17015
45 Japan 29603 C 17015 17015
46 Japan 29604 T 17015 17015
47 Japan 29605 A 17015 17015
48 Japan 29606 C 17015 17015
49 Japan 29607 T 17015 17015
50 Japan 29608 C 17015 17015
51 Japan 29609 T 17015 17015
52 Japan 29610 T 17015 17015
53 Japan 29611 G 17015 17015
54 Japan 29612 T 17015 17015
55 Japan 29613 G 17015 17015
56 Japan 29614 C T 17015 16763 Cys19Cys
57 Japan 29615 A 17015 17015
58 Japan 29616 G T,C 17015 17013 Arg20Ile-p.Arg20Thr
59 Japan 29617 A G 17015 17008 Arg20Arg
60 Japan 29618 A 17017 17017
61 Japan 29619 T 17017 17017
62 Japan 29620 G T 17017 16984 Met21Ile
63 Japan 29621 A T 17017 17016 Asn22Tyr
64 Japan 29622 A G 17017 17016 Asn22Ser
65 Japan 29623 T 17017 17017
66 Japan 29624 T 17016 17016
67 Japan 29625 C T 17016 17015 Ser23Phe
68 Japan 29626 T 17016 17016
69 Japan 29627 C T 17016 17013 Arg24Cys
70 Japan 29628 G T,A 17016 17012 Arg24Leu-p.Arg24His
71 Japan 29629 T 17016 17016
72 Japan 29630 A G 17015 17014 Asn25Asp
73 Japan 29631 A 17015 17015
74 Japan 29632 C T,A 17015 17013 Asn25Lys-p.Asn25Asn
75 Japan 29633 T 17015 17015
76 Japan 29634 A 17015 17015
77 Japan 29635 C T 17015 16946 Tyr26Tyr
78 Japan 29636 A 17015 17015
79 Japan 29637 T 17015 17015
80 Japan 29638 A 17012 17012
81 Japan 29639 G 17012 17012
82 Japan 29640 C T 17012 17006 Ala28Val
83 Japan 29641 A 17012 17012
84 Japan 29642 C T 17012 16974 Gln29*
85 Japan 29643 A 17012 17012
86 Japan 29644 A 17012 17012
87 Japan 29645 G T,A,C 17008 16988 Val30Ile-p.Val30Leu
88 Japan 29646 T 17002 17002
89 Japan 29647 A 17002 17002
90 Japan 29648 G T 17001 16909 Asp31Tyr
91 Japan 29649 A 17000 17000
92 Japan 29650 T 16999 16999
93 Japan 29651 G T 16999 16998 Val32Leu
94 Japan 29652 T 16999 16999
95 Japan 29653 A 16998 16998
96 Japan 29654 G 16998 16998
97 Japan 29655 T 16998 16998
98 Japan 29656 T 16998 16998
99 Japan 29657 A 16998 16998
100 Japan 29658 A 16981 16981
101 Japan 29659 C T 16981 16980 Asn34Asn
102 Japan 29660 T 16981 16981
103 Japan 29661 T 16980 16980
104 Japan 29662 T 16979 16979
105 Japan 29663 A 16978 16978
106 Japan 29664 A 16977 16977
107 Japan 29665 T 16975 16975
108 Japan 29666 C T 16846 16841 Leu37Phe
109 Japan 29667 T 16833 16831
110 Japan 29668 C 16832 16829
111 Japan 29669 A G 16829 16823 Thr38Ala
112 Japan 29670 C 16828 16828
113 Japan 29671 A 16824 16824
114 Japan 29672 T C 16823 16822 Ter39Glnext*?
115 Japan 29673 A 16823 16823
116 Japan 29674 G 16822 16822