National Institute Of Genetic Engineering and Biotechnology

P.I:Mohammad-Ali Malboobi
Here we provide last mutation observed in Nucleocapsid gene of COVID-19 prevalent in Iran.
We kindly wait your comment or coopration in tracking crona virus project.
Amino acid changes

How to read this table:
- Rows are reference amino acids and columns are changed amino acids. E.g. Row 'A' column 'E' indicates how many 'A' amino acids have been replaced by 'E' amino acids.
- Red background colors indicate that more changes happened (heat-map).
- Diagonals are indicated using grey background color
- WARNING: This table may include different translation codon tables (e.g. mamalian DNA and mitochondrial DNA).

  * - ? A C D E F G I K L M N P Q R S T V W Y
*                                            
-     339                                      
?                                            
A     30 11                           1        
C     9   2                                  
D     18     3 1             1                
E     9       2                              
F     12         2                            
G     27           7                 1        
I     6             1                        
K     21               5     1                
L 1   45         7       19                    
M     6                                      
N     21                     2                
P     18                       3     1        
Q     12                         1            
R     18                           2          
S     15   1                       1 4 1      
T     36             2 1     1       2 9      
V     18                                 3    
W     3                                      
Y     15                                     4

Nucleotide and amino acid mutations

Here we provide list of mutation observed in Nucleocapsid at gene and protein of COVID-19.
-The position column is nucleotide position in reference genome as NC_045512.2
-The Reference column indicate reference nucleotide in NC_045512.2
-The NS column indicate number of samples that this position have been observed
-The NSR column indicate number of samples with reference nucleotide. Therefore diffrenciate related to Ns indicate number of sample with mutated nucleotide
Contoury Position Reference Alt. NSR NS AAchange
0 China 12686 A 945 945
1 China 12687 A 945 945
2 China 12688 T 945 945
3 China 12689 A 945 945
4 China 12690 A 945 945
5 China 12691 T 945 945
6 China 12692 G 945 945
7 China 12693 A 945 945
8 China 12694 G A 945 936 Glu4143Glu
9 China 12695 C 945 945
10 China 12696 T 945 945
11 China 12697 T G 945 937 Leu4144Leu
12 China 12698 A 945 945
13 China 12699 G 945 945
14 China 12700 T 945 945
15 China 12701 C 945 945
16 China 12702 C 945 945
17 China 12703 T C,A 945 937 Pro4146Pro-p.Pro4146Pro
18 China 12704 G 945 945
19 China 12705 T 945 945
20 China 12706 T A 945 937 Val4147Val
21 China 12707 G 945 945
22 China 12708 C 945 945
23 China 12709 A 945 945
24 China 12710 C 945 945
25 China 12711 T 945 945
26 China 12712 A T 945 938 Leu4149Leu
27 China 12713 C 945 945
28 China 12714 G 945 945
29 China 12715 A 945 945
30 China 12716 C 945 945
31 China 12717 A 945 945
32 China 12718 G 945 945
33 China 12719 A 945 945
34 China 12720 T 945 945
35 China 12721 G 945 945
36 China 12722 T 945 945
37 China 12723 C 945 945
38 China 12724 T A 945 931 Ser4153Ser
39 China 12725 T 945 945
40 China 12726 G 945 945
41 China 12727 T 945 945
42 China 12728 G 945 945
43 China 12729 C 946 946
44 China 12730 T C,G 946 938 Ala4155Ala-p.Ala4155Ala
45 China 12731 G 946 946
46 China 12732 C 946 946
47 China 12733 C A,T 947 939 Ala4156Ala-p.Ala4156Ala
48 China 12734 G 947 947
49 China 12735 G 947 947
50 China 12736 T 947 947
51 China 12737 A 947 947
52 China 12738 C 947 947
53 China 12739 T A 947 940 Thr4158Thr
54 China 12740 A 947 946
55 China 12741 C T 947 946 Thr4159Ile
56 China 12742 A 947 947
57 China 12743 C 947 947
58 China 12744 A 947 947
59 China 12745 A 947 947
60 China 12746 A 947 947
61 China 12747 C 947 947
62 China 12748 T A 947 932 Thr4161Thr
63 China 12749 G 947 947
64 China 12750 C 947 947
65 China 12751 T A 947 940 Ala4162Ala
66 China 12752 T 947 947
67 China 12753 G 947 947
68 China 12754 C T 947 940 Cys4163Cys
69 China 12755 A 947 947
70 China 12756 C A 947 940 Thr4164Asn
71 China 12757 T 947 947
72 China 12758 G 947 947
73 China 12759 A 947 947
74 China 12760 T G 947 940 Asp4165Glu
75 China 12761 G A 947 946 Asp4166Asn
76 China 12762 A 947 947
77 China 12763 C T 947 933 Asp4166Asp
78 China 12764 A 947 947
79 China 12765 A 947 947
80 China 12766 T 947 947
81 China 12767 G 947 947
82 China 12768 C 947 947
83 China 12769 G T,A 947 931 Ala4168Ala-p.Ala4168Ala
84 China 12770 T C 947 939 Leu4169Leu
85 China 12771 T 947 947
86 China 12772 A T,G 947 945 Leu4169Phe-p.Leu4169Leu
87 China 12773 G T 947 946 Ala4170Ser
88 China 12774 C 947 946
89 China 12775 T C 947 931 Ala4170Ala
90 China 12776 T 947 946
91 China 12777 A 947 946
92 China 12778 C T 947 941 Tyr4171Tyr
93 China 12779 T 947 946
94 China 12780 A 946 944
95 China 12781 C T 946 931 Tyr4172Tyr
96 China 12782 A 946 945
97 China 12783 A 946 944
98 China 12784 C 946 945
99 China 12785 A 946 945
100 China 12786 C A 946 944 Thr4174Lys
101 China 12787 A T,C 946 938 Thr4174Thr-p.Thr4174Thr
102 China 12788 A T 946 937 Thr4175Ser
103 China 12789 C T 946 943 Thr4175Ile
104 China 12790 A 946 945
105 China 12791 A 946 945
106 China 12792 A 946 945
107 China 12793 G T 946 944 Lys4176Asn
108 China 12794 G 946 944
109 China 12795 G 946 945
110 China 12796 A G 946 943 Gly4177Gly
111 China 12797 G A 946 943 Gly4178Ser
112 China 12798 G 946 945
113 China 12799 T 946 945
114 China 12800 A 946 945
115 China 12801 G 946 945
116 China 12802 G 946 945
117 China 12803 T 946 945
118 China 12804 T 946 945
119 China 12805 T 946 945
120 China 12806 G 946 945
121 China 12807 T 946 945
122 China 12808 A T 946 937 Val4181Val
123 China 12809 C T 946 932 Leu4182Phe
124 China 12810 T 946 945
125 China 12811 T A,G 946 931 Leu4182Leu-p.Leu4182Leu
126 China 12812 G 946 945
127 China 12813 C 946 945
128 China 12814 A G 946 944 Ala4183Ala
129 China 12815 C T 946 930 Leu4184Leu
130 China 12816 T 946 946
131 China 12817 G A 946 930 Leu4184Leu
132 China 12818 T C 946 932 Leu4185Leu
133 China 12819 T 946 946
134 China 12820 A 946 946
135 China 12821 T 946 946
136 China 12822 C 946 946
137 China 12823 C T 946 930 Ser4186Ser
138 China 12824 G 946 946
139 China 12825 A 946 946
140 China 12826 T C 946 945 Asp4187Asp
141 China 12827 T C 946 938 Leu4188Leu
142 China 12828 T A 946 945 Leu4188*
143 China 12829 A T,C 946 938 Leu4188Phe-p.Leu4188Phe
144 China 12830 C 946 946
145 China 12831 A 946 946
146 China 12832 G A 946 931 Gln4189Gln
147 China 12833 G 946 946
148 China 12834 A 946 946
149 China 12835 T C 946 938 Asp4190Asp
150 China 12836 T C 946 938 Leu4191Leu
151 China 12837 T 946 946
152 China 12838 G C,T 946 938 Leu4191Phe-p.Leu4191Phe
153 China 12839 A 946 946
154 China 12840 A 946 946
155 China 12841 A G 946 933 Lys4192Lys
156 China 12842 T 946 946
157 China 12843 G 946 946
158 China 12844 G 946 946
159 China 12845 G 946 946
160 China 12846 C 946 946
161 China 12847 T C 946 940 Ala4194Ala
162 China 12848 A 946 946
163 China 12849 G 946 945
164 China 12850 A G 946 939 Arg4195Arg
165 China 12851 T 946 946
166 China 12852 T 946 946
167 China 12853 C T 946 939 Phe4196Phe
168 China 12854 C 946 946
169 China 12855 C 946 946
170 China 12856 T 946 945
171 China 12857 A 946 945
172 China 12858 A 946 945
173 China 12859 G A 946 938 Lys4198Lys
174 China 12860 A T 946 938 Ser4199Cys
175 China 12861 G C 946 938 Ser4199Thr
176 China 12862 T C,G 946 943 Ser4199Arg-p.Ser4199Ser
177 China 12863 G 946 945
178 China 12864 A 946 945
179 China 12865 T 945 944
180 China 12866 G 945 944
181 China 12867 G 945 944
182 China 12868 A T 945 936 Gly4201Gly
183 China 12869 A T 945 943 Thr4202Ser
184 China 12870 C 945 944
185 China 12871 T G 945 943 Thr4202Thr
186 China 12872 G 945 944
187 China 12873 G 945 944
188 China 12874 T C 945 930 Gly4203Gly
189 China 12875 A 945 944
190 China 12876 C 945 944
191 China 12877 T C,A 945 936 Thr4204Thr-p.Thr4204Thr
192 China 12878 A 945 944
193 China 12879 T 945 944
194 China 12880 C T 945 929 Ile4205Ile
195 China 12881 T 945 945
196 China 12882 A 945 945
197 China 12883 T 945 945
198 China 12884 A 945 945
199 China 12885 C 945 945
200 China 12886 A G 945 938 Thr4207Thr
201 China 12887 G 945 945
202 China 12888 A 945 945
203 China 12889 A G 945 938 Glu4208Glu
204 China 12890 C 945 945
205 China 12891 T 945 945
206 China 12892 G 945 945
207 China 12893 G 945 945
208 China 12894 A 945 945
209 China 12895 A 945 945
210 China 12896 C T 945 939 Pro4211Ser
211 China 12897 C 945 945
212 China 12898 A 945 945
213 China 12899 C 945 945
214 China 12900 C 945 945
215 China 12901 T 945 945
216 China 12902 T 945 945
217 China 12903 G 945 945
218 China 12904 T C 945 944 Cys4213Cys
219 China 12905 A 945 945
220 China 12906 G 945 945
221 China 12907 G 945 945
222 China 12908 T 944 944
223 China 12909 T 944 944
224 China 12910 T 944 944
225 China 12911 G 944 944
226 China 12912 T 944 944
227 China 12913 T 944 944
228 China 12914 A 944 944
229 China 12915 C 944 944
230 China 12916 A 944 944
231 China 12917 G 944 944
232 China 12918 A 944 944
233 China 12919 C 944 944
234 China 12920 A 944 944
235 China 12921 C 944 944
236 China 12922 A 944 944
237 China 12923 C 944 944
238 China 12924 C 944 944
239 China 12925 T A 945 930 Pro4220Pro
240 China 12926 A 945 945
241 China 12927 A 945 945
242 China 12928 A G 945 938 Lys4221Lys
243 China 12929 G 945 945
244 China 12930 G 945 945
245 China 12931 T A 945 937 Gly4222Gly
246 China 12932 C 945 945
247 China 12933 C 945 945
248 China 12934 T 945 945
249 China 12935 A 945 945
250 China 12936 A 945 945
251 China 12937 A 945 945
252 China 12938 G 945 945
253 China 12939 T 945 945
254 China 12940 G A 945 938 Val4225Val
255 China 12941 A 945 945
256 China 12942 A 945 945
257 China 12943 G A 945 938 Lys4226Lys
258 China 12944 T 945 945
259 China 12945 A 945 945
260 China 12946 T C 945 938 Tyr4227Tyr
261 China 12947 T 945 945
262 China 12948 T 945 945
263 China 12949 A G 945 930 Leu4228Leu
264 China 12950 T 945 945
265 China 12951 A 945 945
266 China 12952 C T 945 938 Tyr4229Tyr
267 China 12953 T 945 945
268 China 12954 T 945 945
269 China 12955 T C 945 938 Phe4230Phe
270 China 12956 A 945 945
271 China 12957 T 945 945
272 China 12958 T 945 945
273 China 12959 A 945 945
274 China 12960 A 945 945
275 China 12961 A G 944 930 Lys4232Lys
276 China 12962 G 944 944
277 China 12963 G 944 944
278 China 12964 A T 944 931 Gly4233Gly
279 China 12965 T C 944 937 Leu4234Leu
280 China 12966 T 944 944
281 China 12967 A G 944 938 Leu4234Leu
282 China 12968 A 944 944
283 China 12969 A 944 944
284 China 12970 C T 944 937 Asn4235Asn
285 China 12971 A 944 944
286 China 12972 A 944 944
287 China 12973 C T 944 930 Asn4236Asn
288 China 12974 C T 944 937 Leu4237Leu
289 China 12975 T 944 944
290 China 12976 A G 944 937 Leu4237Leu
291 China 12977 A 944 944
292 China 12978 A 944 944
293 China 12979 T 944 944
294 China 12980 A 944 944
295 China 12981 G 944 944
296 China 12982 A 944 944
297 China 12983 G 944 944
298 China 12984 G 944 944
299 China 12985 T C 944 943 Gly4240Gly
300 China 12986 A 944 944
301 China 12987 T 944 944
302 China 12988 G 944 944
303 China 12989 G 944 944
304 China 12990 T 944 944
305 China 12991 A 944 944
306 China 12992 C T 944 938 Leu4243Phe
307 China 12993 T 944 944
308 China 12994 T G 944 930 Leu4243Leu
309 China 12995 G 944 944
310 China 12996 G 944 944
311 China 12997 T C 944 936 Gly4244Gly
312 China 12998 A 944 944
313 China 12999 G 944 944
314 China 13000 T C 944 938 Ser4245Ser
315 China 13001 T 944 944
316 China 13002 T 944 944
317 China 13003 A 944 944
318 China 13004 G 944 943
319 China 13005 C 944 944
320 China 13006 T 944 944
321 China 13007 G 944 944
322 China 13008 C 944 944
323 China 13009 C T 944 929 Ala4248Ala
324 China 13010 A 944 944
325 China 13011 C 944 944
326 China 13012 A T 944 937 Thr4249Thr
327 China 13013 G 944 944
328 China 13014 T 944 944
329 China 13015 A 944 944
330 China 13016 C 944 944
331 China 13017 G 944 944
332 China 13018 T C 944 938 Arg4251Arg
333 China 13019 C T 944 928 Leu4252Leu
334 China 13020 T 944 944
335 China 13021 A T 944 943 Leu4252Leu
336 China 13022 C 944 944
337 China 13023 A 944 944
338 China 13024 A 937 937