National Institute Of Genetic Engineering and Biotechnology

P.I:Mohammad-Ali Malboobi
Here we provide last mutation observed in Nucleocapsid gene of COVID-19 prevalent in Iran.
We kindly wait your comment or coopration in tracking crona virus project.

Amino acid changes

How to read this table:
- Rows are reference amino acids and columns are changed amino acids. E.g. Row 'A' column 'E' indicates how many 'A' amino acids have been replaced by 'E' amino acids.
- Red background colors indicate that more changes happened (heat-map).
- Diagonals are indicated using grey background color
- WARNING: This table may include different translation codon tables (e.g. mamalian DNA and mitochondrial DNA).

  * - ? A C D E F G H I K L M N P Q R S T V W Y
*                                              
-     413                                        
?                                              
A     38 12                             4 4 7    
C     39   9     3                   1 2       1
D     21 2   7 3   4           3           1    
E 1   12 1   1 3         2                 1    
F     15         2         3           1        
G     39   3       14                 2 4   2    
H     9             3               1         1
I     12               1   1 2           2 4    
K     24       1       1 6   2 1   1 5          
L     24         3     2   12       1 1          
M     11               5 1 3             3 3    
N     20     1       2   4     5       5 1     1
P     23             3     4     10 1   5 1      
Q     18             3   1 2       4 1          
R     6   1         1               3 1        
S     18 1         1   1       2       8       1
T     39 5             12       2       1 15      
V     27 3       1     7   2               10    
W     3                   1                    
Y     15   1                                   5

Nucleotide and amino acid mutations

Here we provide list of mutation observed in Nucleocapsid at gene and protein of COVID-19.
-The position column is nucleotide position in reference genome as NC_045512.2
-The Reference column indicate reference nucleotide in NC_045512.2
-The NS column indicate number of samples that this position have been observed
-The NSR column indicate number of samples with reference nucleotide. Therefore diffrenciate related to Ns indicate number of sample with mutated nucleotide

Contoury Position Reference Alt. NSR NS AAchange
0 England 13026 C 190388 190388
1 England 13027 T 190395 190395
2 England 13028 G A 190415 190412 Gly4255Ser
3 England 13029 G T 190415 190412 Gly4255Val
4 England 13030 T C 190537 190531 Gly4255Gly
5 England 13031 A 190537 190535
6 England 13032 A G,C 190539 190529 Asn4256Ser-p.Asn4256Thr
7 England 13033 T A,G 190539 190533 Asn4256Lys-p.Asn4256Lys
8 England 13034 G 190540 190539
9 England 13035 C T 190540 190510 Ala4257Val
10 England 13036 A G,T 190540 190534 Ala4257Ala-p.Ala4257Ala
11 England 13037 A G 190540 190539 Thr4258Ala
12 England 13038 C T 190540 190529 Thr4258Ile
13 England 13039 A G 190540 190532 Thr4258Thr
14 England 13040 G 190540 190538
15 England 13041 A 190540 190539
16 England 13042 A 190540 190538
17 England 13043 G T 190540 190532 Val4260Leu
18 England 13044 T C 190540 190538 Val4260Ala
19 England 13045 G T 190540 190502 Val4260Val
20 England 13046 C T 190540 190532 Pro4261Ser
21 England 13047 C T,A 190540 190532 Pro4261Leu-p.Pro4261His
22 England 13048 T A 190540 190538 Pro4261Pro
23 England 13049 G 190541 190538
24 England 13050 C T 190541 190540 Ala4262Val
25 England 13051 C T 190541 190522 Ala4262Ala
26 England 13052 A 190541 190541
27 England 13053 A 190541 190541
28 England 13054 T C 190541 190539 Asn4263Asn
29 England 13055 T 190541 190541
30 England 13056 C 190541 190539
31 England 13057 A G,C 190541 190534 Ser4264Ser-p.Ser4264Ser
32 England 13058 A 190541 190539
33 England 13059 C T,A 190542 190238 Thr4265Ile-p.Thr4265Asn
34 England 13060 T C 190542 190540 Thr4265Thr
35 England 13061 G A 190542 190540 Val4266Ile
36 England 13062 T 190542 190542
37 England 13063 A G 190542 190514 Val4266Val
38 England 13064 T C 190542 190513 Leu4267Leu
39 England 13065 T 190542 190542
40 England 13066 A G 190542 190529 Leu4267Leu
41 England 13067 T 190542 190542
42 England 13068 C A 190542 190537 Ser4268Tyr
43 England 13069 T G,C 190542 190534 Ser4268Ser-p.Ser4268Ser
44 England 13070 T C 190542 190541 Phe4269Leu
45 England 13071 T 190542 190542
46 England 13072 C T,A 190542 190490 Phe4269Leu-p.Phe4269Phe
47 England 13073 T 190542 190542
48 England 13074 G T 190542 190541 Cys4270Phe
49 England 13075 T C 190541 190539 Cys4270Cys
50 England 13076 G 190540 190538
51 England 13077 C T 190540 190531 Ala4271Val
52 England 13078 T C 190540 190523 Ala4271Ala
53 England 13079 T 190540 190536
54 England 13080 T 190540 190536
55 England 13081 T 190540 190537
56 England 13082 G T 190540 190536 Ala4273Ser
57 England 13083 C T 190538 190530 Ala4273Val
58 England 13084 T 190538 190535
59 England 13085 G A 190538 190531 Val4274Ile
60 England 13086 T 190537 190535
61 England 13087 A G 190537 190531 Val4274Val
62 England 13088 G A 190537 190530 Asp4275Asn
63 England 13089 A 190537 190535
64 England 13090 T C 190538 190526 Asp4275Asp
65 England 13091 G A 190537 190524 Ala4276Thr
66 England 13092 C 190537 190532
67 England 13093 T A 190537 190533 Ala4276Ala
68 England 13094 G A 190537 190529 Ala4277Thr
69 England 13095 C T 190537 190504 Ala4277Val
70 England 13096 T C 190536 190525 Ala4277Ala
71 England 13097 A 190534 190529
72 England 13098 A 190534 190530
73 England 13099 A G 190534 190528 Lys4278Lys
74 England 13100 G 190534 190530
75 England 13101 C 190534 190531
76 England 13102 T 190534 190530
77 England 13103 T 190534 190531
78 England 13104 A 190534 190531
79 England 13105 C T 190534 190512 Tyr4280Tyr
80 England 13106 A 190534 190530
81 England 13107 A 190534 190530
82 England 13108 A 190534 190529
83 England 13109 G 190534 190532
84 England 13110 A T,G 190534 190530 Asp4282Val-p.Asp4282Gly
85 England 13111 T C 190534 190515 Asp4282Asp
86 England 13112 T 190534 190530
87 England 13113 A G 190534 190527 Tyr4283Cys
88 England 13114 T C 190536 190491 Tyr4283Tyr
89 England 13115 C T 190536 190418 Leu4284Leu
90 England 13116 T A 190536 190529 Leu4284Gln
91 England 13117 A 190536 190526
92 England 13118 G A 190536 190521 Ala4285Thr
93 England 13119 C T 190536 190486 Ala4285Val
94 England 13120 T 190536 190530
95 England 13121 A 190536 190531
96 England 13122 G A 190536 190528 Ser4286Asn
97 England 13123 T C 190536 190527 Ser4286Ser
98 England 13124 G A 190536 190523 Gly4287Arg
99 England 13125 G T 190536 190528 Gly4287Val
100 England 13126 G A,T 190536 190475 Gly4287Gly-p.Gly4287Gly
101 England 13127 G A 190536 190528 Gly4288Arg
102 England 13128 G 190536 190530
103 England 13129 A G,T 190536 190522 Gly4288Gly-p.Gly4288Gly
104 England 13130 C 190536 190526
105 England 13131 A 190536 190528
106 England 13132 A 190536 190526
107 England 13133 C T 190537 190523 Pro4290Ser
108 England 13134 C 190537 190526
109 England 13135 A G 190537 190523 Pro4290Pro
110 England 13136 A G,C 190537 190525 Ile4291Val-p.Ile4291Leu
111 England 13137 T 190538 190527
112 England 13138 C T 190538 190504 Ile4291Ile
113 England 13139 A 190538 190528
114 England 13140 C T,A 190538 190517 Thr4292Ile-p.Thr4292Asn
115 England 13141 T 190538 190526
116 England 13142 A 190538 190526
117 England 13143 A 190538 190527
118 England 13144 T 190538 190528
119 England 13145 T 190538 190524
120 England 13146 G 190539 190529
121 England 13147 T C 190539 190530 Cys4294Cys
122 England 13148 G A 190539 190523 Val4295Ile
123 England 13149 T 190539 190530
124 England 13150 T 190540 190532
125 England 13151 A 190540 190533
126 England 13152 A G,T 190540 190531 Lys4296Arg-p.Lys4296Met
127 England 13153 G A 190540 190529 Lys4296Lys
128 England 13154 A 190540 190535
129 England 13155 T 190539 190531
130 England 13156 G 190539 190532
131 England 13157 T C 190539 190531 Leu4298Leu
132 England 13158 T 190539 190533
133 England 13159 G A 190540 190530 Leu4298Leu
134 England 13160 T 190540 190536
135 England 13161 G 190540 190536
136 England 13162 T 190540 190533
137 England 13163 A 190540 190533
138 England 13164 C T 190540 190526 Thr4300Ile
139 England 13165 A G 190540 190533 Thr4300Thr
140 England 13166 C T 190540 190522 His4301Tyr
141 England 13167 A G 190540 190531 His4301Arg
142 England 13168 C T 190540 190430 His4301His
143 England 13169 A T,G 190539 190530 Thr4302Ser-p.Thr4302Ala
144 England 13170 C T 190540 190499 Thr4302Ile
145 England 13171 T C,A 190540 190533 Thr4302Thr-p.Thr4302Thr
146 England 13172 G T 190540 190535 Gly4303Cys
147 England 13173 G 190540 190537
148 England 13174 T 190540 190536
149 England 13175 A G 190540 190536 Thr4304Ala
150 England 13176 C T 190540 190453 Thr4304Ile
151 England 13177 T A,C 190540 190511 Thr4304Thr-p.Thr4304Thr
152 England 13178 G 190540 190536
153 England 13179 G 190540 190536
154 England 13180 T C 190540 190520 Gly4305Gly
155 England 13181 C 190540 190537
156 England 13182 A G,T 190540 190525 Gln4306Arg-p.Gln4306Leu
157 England 13183 G A,T 190540 190513 Gln4306His-p.Gln4306Gln
158 England 13184 G T 190540 190536 Ala4307Ser
159 England 13185 C 190540 190536
160 England 13186 A T,G 190540 190530 Ala4307Ala-p.Ala4307Ala
161 England 13187 A G 190540 190528 Ile4308Val
162 England 13188 T C 190540 190534 Ile4308Thr
163 England 13189 A G 190540 190534 Ile4308Met
164 England 13190 A G 190540 190522 Thr4309Ala
165 England 13191 C 190540 190538
166 England 13192 A C,G 190540 190529 Thr4309Thr-p.Thr4309Thr
167 England 13193 G A 190540 190536 Val4310Ile
168 England 13194 T 190540 190538
169 England 13195 T C,A 190540 190517 Val4310Val-p.Val4310Val
170 England 13196 A 190540 190540
171 England 13197 C T 190541 190525 Thr4311Ile
172 England 13198 A G 190541 190362 Thr4311Thr
173 England 13199 C A 190541 190457 Pro4312Thr
174 England 13200 C 190541 190541
175 England 13201 G T,A,C 190541 190496 Pro4312Pro-p.Pro4312Pro
176 England 13202 G A 190541 190535 Glu4313Lys
177 England 13203 A C 190541 190537 Glu4313Ala
178 England 13204 A G 190541 190533 Glu4313Glu
179 England 13205 G T 190541 190537 Ala4314Ser
180 England 13206 C 190542 190538
181 England 13207 C T 190542 190516 Ala4314Ala
182 England 13208 A 190542 190541
183 England 13209 A G 190542 190539 Asn4315Ser
184 England 13210 T C 190542 190538 Asn4315Asn
185 England 13211 A G 190542 190540 Met4316Val
186 England 13212 T C 190542 190476 Met4316Thr
187 England 13213 G A 190542 190538 Met4316Ile
188 England 13214 G 190542 190541
189 England 13215 A 190542 190542
190 England 13216 T G,C 190542 190211 Asp4317Glu-p.Asp4317Asp
191 England 13217 C 190542 190541
192 England 13218 A 190542 190540
193 England 13219 A G,C 190542 190537 Gln4318His-p.Gln4318Gln
194 England 13220 G 190542 190537
195 England 13221 A T 190542 190539 Glu4319Val
196 England 13222 A G,C 190542 190531 Glu4319Asp-p.Glu4319Glu
197 England 13223 T G 190542 190539 Ser4320Ala
198 England 13224 C 190542 190540
199 England 13225 C T,A 190542 190503 Ser4320Ser-p.Ser4320Ser
200 England 13226 T 190542 190539
201 England 13227 T 190542 190540
202 England 13228 T 190542 190540
203 England 13229 G 190542 190540
204 England 13230 G 190542 190539
205 England 13231 T 190542 190540
206 England 13232 G 190542 190540
207 England 13233 G 190542 190539
208 England 13234 T C 190542 190537 Gly4323Gly
209 England 13235 G A 190542 190535 Ala4324Thr
210 England 13236 C 190543 190539
211 England 13237 A T,C 190543 190528 Ala4324Ala-p.Ala4324Ala
212 England 13238 T 190543 190538
213 England 13239 C 190543 190538
214 England 13240 G A 190544 190514 Ser4325Ser
215 England 13241 T 190544 190540
216 England 13242 G T 190545 190537 Cys4326Phe
217 England 13243 T 190545 190539
218 England 13244 T 190545 190540
219 England 13245 G 190545 190540
220 England 13246 T C 190544 190539 Cys4327Cys
221 England 13247 C T 190544 190367 Leu4328Leu
222 England 13248 T 190545 190541
223 England 13249 G T 190545 190344 Leu4328Leu
224 England 13250 T 190545 190541
225 England 13251 A 190545 190540
226 England 13252 C T 190545 190531 Tyr4329Tyr
227 England 13253 T 190545 190538
228 England 13254 G 190545 190539
229 England 13255 C T 190545 190523 Cys4330Cys
230 England 13256 C 190544 190539
231 England 13257 G 190545 190539
232 England 13258 T C 190545 190536 Arg4331Arg
233 England 13259 T 190545 190540
234 England 13260 G 190545 190541
235 England 13261 C T 190545 190496 Cys4332Cys
236 England 13262 C 190545 190541
237 England 13263 A 190544 190539
238 England 13264 C T 190544 190502 His4333His
239 England 13265 A G 190542 190528 Ile4334Val
240 England 13266 T C 190542 190530 Ile4334Thr
241 England 13267 A G 190541 190531 Ile4334Met
242 England 13268 G A 190541 190525 Asp4335Asn
243 England 13269 A G 190542 190529 Asp4335Gly
244 England 13270 T C 190542 190514 Asp4335Asp
245 England 13271 C 190542 190529
246 England 13272 A 190542 190533
247 England 13273 T C 190542 190517 His4336His
248 England 13274 C T 190542 190474 Pro4337Ser
249 England 13275 C T,A 190542 190519 Pro4337Leu-p.Pro4337Gln
250 England 13276 A C 190541 190531 Pro4337Pro
251 England 13277 A C,G 190541 190530 Asn4338His-p.Asn4338Asp
252 England 13278 A G 190541 190509 Asn4338Ser
253 England 13279 T C 190540 190530 Asn4338Asn
254 England 13280 C T 190540 190527 Pro4339Ser
255 England 13281 C T,A 190540 190501 Pro4339Leu-p.Pro4339His
256 England 13282 T C 190540 190532 Pro4339Pro
257 England 13283 A 190540 190531
258 England 13284 A G 190540 190532 Lys4340Arg
259 England 13285 A G 190540 190526 Lys4340Lys
260 England 13286 G 190540 190533
261 England 13287 G 190538 190529
262 England 13288 A C,G 190538 190513 Gly4341Gly-p.Gly4341Gly
263 England 13289 T C 190538 190527 Phe4342Leu
264 England 13290 T C 190537 190531 Phe4342Ser
265 England 13291 T 190537 190533
266 England 13292 T 190537 190524
267 England 13293 G C 190537 190523 Cys4343Ser
268 England 13294 T C 190536 190521 Cys4343Cys
269 England 13295 G 190536 190520
270 England 13296 A C,G 190536 190513 Asp4344Ala-p.Asp4344Gly
271 England 13297 C T,A 190536 190396 Asp4344Glu-p.Asp4344Asp
272 England 13298 T C 190536 190523 Leu4345Leu
273 England 13299 T 190536 190517
274 England 13300 A 190536 190520
275 England 13301 A 190535 190522
276 England 13302 A G 190535 190521 Lys4346Arg
277 England 13303 A 190535 190517
278 England 13304 G 190535 190519
279 England 13305 G 190535 190521
280 England 13306 T 190535 190522
281 England 13307 A 190535 190523
282 England 13308 A G,T 190535 190492 Lys4348Arg-p.Lys4348Met
283 England 13309 G A,T 190535 190513 Lys4348Asn-p.Lys4348Lys
284 England 13310 T 190535 190519
285 England 13311 A 190535 190518
286 England 13312 T C 190535 190515 Tyr4349Tyr
287 England 13313 G A 190535 190508 Val4350Ile
288 England 13314 T C 190535 190517 Val4350Ala
289 England 13315 A G 190535 190512 Val4350Val
290 England 13316 C 190534 190514
291 England 13317 A 190533 190513
292 England 13318 A G 190533 190502 Gln4351Gln
293 England 13319 A G 190533 190506 Ile4352Val
294 England 13320 T 190533 190512
295 England 13321 A 190533 190512
296 England 13322 C 190533 190513
297 England 13323 C 190532 190510
298 England 13324 T C 190532 190511 Pro4353Pro
299 England 13325 A 190532 190513
300 England 13326 C T 190532 190445 Thr4354Ile
301 England 13327 A T 190535 190513 Thr4354Thr
302 England 13328 A G 190535 190511 Thr4355Ala
303 England 13329 C T 190535 190163 Thr4355Ile
304 England 13330 T C 190535 190508 Thr4355Thr
305 England 13331 T C,A 190535 190509 Cys4356Arg-p.Cys4356Ser
306 England 13332 G A 190539 190519 Cys4356Tyr
307 England 13333 T C 190539 190514 Cys4356Cys
308 England 13334 G T 190539 190509 Ala4357Ser
309 England 13335 C T 190539 190341 Ala4357Val
310 England 13336 T C 190539 190511 Ala4357Ala
311 England 13337 A T 190551 190529 Asn4358Tyr
312 England 13338 A G 190551 190529 Asn4358Ser
313 England 13339 T C,A,G 190551 190509 Asn4358Lys-p.Asn4358Asn
314 England 13340 G 190549 190528
315 England 13341 A 190549 190528
316 England 13342 C T 190549 190494 Asp4359Asp
317 England 13343 C 190549 190529
318 England 13344 C 190549 190529
319 England 13345 T C 190584 190570 Pro4360Pro
320 England 13346 G T 190584 190572 Val4361Leu
321 England 13347 T 190584 190577
322 England 13348 G T,A 190584 190455 Val4361Val-p.Val4361Val
323 England 13349 G 190585 190577
324 England 13350 G 190585 190578
325 England 13351 T C 190585 190572 Gly4362Gly
326 England 13352 T 190585 190578
327 England 13353 T 190585 190576
328 England 13354 T C 190585 190577 Phe4363Phe
329 England 13355 A 190585 190579
330 England 13356 C T 190585 190539 Thr4364Ile
331 England 13357 A 190585 190577
332 England 13358 C T 190585 190574 Leu4365Phe
333 England 13359 T 190584 190578
334 England 13360 T C 190584 190544 Leu4365Leu
335 England 13361 A 190585 190578
336 England 13362 A T 190586 190576 Lys4366Ile
337 England 13363 A G 190586 190579 Lys4366Lys
338 England 13364 A C 189840 189750 Asn4367His
339 England 13365 A G 189840 189753 Asn4367Ser
340 England 13366 C T 189840 189740 Asn4367Asn
341 England 13367 A 189840 189757
342 England 13368 C T 189840 189754 Thr4368Ile
343 England 13369 A G 189838 189768 Thr4368Thr
344 England 13370 G A 189839 189757 Val4369Ile
345 England 13371 T C 189838 189773 Val4369Ala
346 England 13372 C T 189838 189612 Val4369Val
347 England 13373 T 189837 189784
348 England 13374 G T 189837 189778 Cys4370Phe
349 England 13375 T 189837 189809
350 England 13376 A 189837 189808
351 England 13377 C T 189834 189805 Thr4371Ile
352 England 13378 C T,A 189808 189708 Thr4371Thr-p.Thr4371Thr
353 England 13379 G A,T 189084 188975 Val4372Ile-p.Val4372Phe
354 England 13380 T 189001 188902
355 England 13381 C T 188982 188635 Val4372Val
356 England 13382 T 188977 188877
357 England 13383 G 188964 188864
358 England 13384 C T 188964 188778 Cys4373Cys
359 England 13385 G A 188961 188831 Gly4374Ser
360 England 13386 G 188932 188845
361 England 13387 T C 188912 188819 Gly4374Gly
362 England 13388 A G,C 188902 188799 Met4375Val-p.Met4375Leu
363 England 13389 T C,A 188881 188783 Met4375Thr-p.Met4375Lys
364 England 13390 G A,T 188870 188800 Met4375Ile-p.Met4375Ile
365 England 13391 T 188865 188812
366 England 13392 G T 188668 188602 Trp4376Leu
367 England 13393 G 188586 188521
368 England 13394 A G,C 188320 188218 Lys4377Glu-p.Lys4377Gln
369 England 13395 A G 188097 187969 Lys4377Arg
370 England 13396 A G 188094 187943 Lys4377Lys
371 England 13397 G A,T 188092 188004 Gly4378Ser-p.Gly4378Cys
372 England 13398 G 188091 188017
373 England 13399 T C 188085 188002 Gly4378Gly
374 England 13400 T 188078 187992
375 England 13401 A 188035 187998
376 England 13402 T C 188033 188001 Tyr4379Tyr
377 England 13403 G A,T 188033 187998 Gly4380Ser-p.Gly4380Cys
378 England 13404 G 188031 188002
379 England 13405 C T,A 188029 187997 Gly4380Gly-p.Gly4380Gly
380 England 13406 T 188002 187972
381 England 13407 G 188002 187975
382 England 13408 T 187996 187975
383 England 13409 A G 187993 187952 Ser4382Gly
384 England 13410 G T,A 187992 187970 Ser4382Ile-p.Ser4382Asn
385 England 13411 T 187990 187971
386 England 13412 T 187987 187968
387 England 13413 G 187987 187973
388 England 13414 T C 187983 187966 Cys4383Cys
389 England 13415 G A 187981 187961 Asp4384Asn
390 England 13416 A G,C 187977 187947 Asp4384Gly-p.Asp4384Ala
391 England 13417 T C,G 187977 187942 Asp4384Glu-p.Asp4384Asp
392 England 13418 C A 187976 187973 Gln4385Lys
393 England 13419 A T 187976 187972 Gln4385Leu
394 England 13420 A G,C 187976 187967 Gln4385His-p.Gln4385Gln
395 England 13421 C T,A 187974 187913 Leu4386Phe-p.Leu4386Ile
396 England 13422 T G 187965 187943 Leu4386Arg
397 England 13423 C T,A 187962 187880 Leu4386Leu-p.Leu4386Leu
398 England 13424 C T,A 187959 187820 Arg4387Cys-p.Arg4387Ser
399 England 13425 G A 187958 187932 Arg4387His
400 England 13426 C T,A 187956 187864 Arg4387Arg-p.Arg4387Arg
401 England 13427 G T,A 187951 187940 Glu4388*-p.Glu4388Lys
402 England 13428 A 187946 187939
403 England 13429 A G 187944 187927 Glu4388Glu
404 England 13430 C T 187943 187677 Pro4389Ser
405 England 13431 C T,A 187942 187904 Pro4389Leu-p.Pro4389His
406 England 13432 C T 187936 187917 Pro4389Pro
407 England 13433 A G,T,C 187932 187895 Met4390Leu-p.Met4390Leu
408 England 13434 T C 187931 187928 Met4390Thr
409 England 13435 G A,T 187930 187895 Met4390Ile-p.Met4390Ile
410 England 13436 C T,A 187926 187833 Leu4391Phe-p.Leu4391Ile
411 England 13437 T 187921 187915
412 England 13438 T C 187920 187912 Leu4391Leu
413 England 13439 C 187916 187914
414 England 13440 A 187914 187914
415 England 13441 G 187904 187904