National Institute Of Genetic Engineering and Biotechnology

P.I:Mohammad-Ali Malboobi
Here we provide last mutation observed in Nucleocapsid gene of COVID-19 prevalent in Iran.
We kindly wait your comment or coopration in tracking crona virus project.
Amino acid changes

How to read this table:
- Rows are reference amino acids and columns are changed amino acids. E.g. Row 'A' column 'E' indicates how many 'A' amino acids have been replaced by 'E' amino acids.
- Red background colors indicate that more changes happened (heat-map).
- Diagonals are indicated using grey background color
- WARNING: This table may include different translation codon tables (e.g. mamalian DNA and mitochondrial DNA).

  * - ? A C D E F G H I K L M N P Q R S T V W Y
*                                              
-     416                                        
?                                              
A     38 11                       1     1        
C     39   4                                    
D     21     4 1                                
E     12                                        
F     15         3                             1
G     39           8                            
H     9             1                          
I     12               2                        
K     24                 3           1          
L     24         3         6                    
M     12                                        
N     21                       4                
P     24                         4              
Q     18                           1            
R     6                             1 1        
S     18                               2        
T     39 1             1                 8      
V     27                                   5    
W     3                                        
Y 1   15                                       2

Nucleotide and amino acid mutations

Here we provide list of mutation observed in Nucleocapsid at gene and protein of COVID-19.
-The position column is nucleotide position in reference genome as NC_045512.2
-The Reference column indicate reference nucleotide in NC_045512.2
-The NS column indicate number of samples that this position have been observed
-The NSR column indicate number of samples with reference nucleotide. Therefore diffrenciate related to Ns indicate number of sample with mutated nucleotide
Contoury Position Reference Alt. NSR NS AAchange
0 China 13026 C 943 943
1 China 13027 T 943 943
2 China 13028 G 944 944
3 China 13029 G 944 944
4 China 13030 T C,A 944 937 Gly4255Gly-p.Gly4255Gly
5 China 13031 A 944 944
6 China 13032 A 944 944
7 China 13033 T 944 944
8 China 13034 G 944 944
9 China 13035 C 944 944
10 China 13036 A T 945 944 Ala4257Ala
11 China 13037 A 945 945
12 China 13038 C 945 945
13 China 13039 A G 945 944 Thr4258Thr
14 China 13040 G 945 945
15 China 13041 A 945 945
16 China 13042 A 945 945
17 China 13043 G 945 945
18 China 13044 T 945 945
19 China 13045 G A 945 937 Val4260Val
20 China 13046 C 945 945
21 China 13047 C 945 945
22 China 13048 T 945 945
23 China 13049 G 945 945
24 China 13050 C 945 945
25 China 13051 C 945 945
26 China 13052 A 945 945
27 China 13053 A 945 944
28 China 13054 T C 945 937 Asn4263Asn
29 China 13055 T 945 944
30 China 13056 C 945 944
31 China 13057 A 945 944
32 China 13058 A 945 944
33 China 13059 C 945 945
34 China 13060 T 945 945
35 China 13061 G 945 945
36 China 13062 T 945 945
37 China 13063 A G,T 945 930 Val4266Val-p.Val4266Val
38 China 13064 T C 945 929 Leu4267Leu
39 China 13065 T 945 945
40 China 13066 A T,C 945 937 Leu4267Phe-p.Leu4267Phe
41 China 13067 T 945 945
42 China 13068 C 945 945
43 China 13069 T A 945 944 Ser4268Ser
44 China 13070 T 945 945
45 China 13071 T 945 945
46 China 13072 C T 945 936 Phe4269Phe
47 China 13073 T 945 945
48 China 13074 G 945 945
49 China 13075 T 945 945
50 China 13076 G 945 945
51 China 13077 C 945 945
52 China 13078 T A,C 945 938 Ala4271Ala-p.Ala4271Ala
53 China 13079 T 945 945
54 China 13080 T 945 945
55 China 13081 T C 945 944 Phe4272Phe
56 China 13082 G 945 945
57 China 13083 C 945 945
58 China 13084 T 945 945
59 China 13085 G 945 945
60 China 13086 T 945 945
61 China 13087 A 945 945
62 China 13088 G 945 945
63 China 13089 A 945 945
64 China 13090 T 945 945
65 China 13091 G C 945 944 Ala4276Pro
66 China 13092 C 945 945
67 China 13093 T A,C 945 929 Ala4276Ala-p.Ala4276Ala
68 China 13094 G T 945 938 Ala4277Ser
69 China 13095 C 945 945
70 China 13096 T A 945 938 Ala4277Ala
71 China 13097 A 945 945
72 China 13098 A 945 945
73 China 13099 A G 945 938 Lys4278Lys
74 China 13100 G 945 945
75 China 13101 C 946 946
76 China 13102 T G,A 946 944 Ala4279Ala-p.Ala4279Ala
77 China 13103 T 946 946
78 China 13104 A 946 946
79 China 13105 C T 946 939 Tyr4280Tyr
80 China 13106 A 946 946
81 China 13107 A G 946 939 Lys4281Arg
82 China 13108 A G 946 945 Lys4281Lys
83 China 13109 G 946 946
84 China 13110 A 946 946
85 China 13111 T C 946 939 Asp4282Asp
86 China 13112 T 946 946
87 China 13113 A 946 946
88 China 13114 T C 946 932 Tyr4283Tyr
89 China 13115 C T 946 945 Leu4284Leu
90 China 13116 T 946 946
91 China 13117 A 946 946
92 China 13118 G 946 946
93 China 13119 C 946 946
94 China 13120 T A 946 938 Ala4285Ala
95 China 13121 A 946 946
96 China 13122 G 946 946
97 China 13123 T 946 946
98 China 13124 G 946 946
99 China 13125 G 946 946
100 China 13126 G A 946 931 Gly4287Gly
101 China 13127 G 946 946
102 China 13128 G 946 946
103 China 13129 A 946 946
104 China 13130 C 946 946
105 China 13131 A 946 946
106 China 13132 A 946 946
107 China 13133 C 946 946
108 China 13134 C 946 946
109 China 13135 A 946 946
110 China 13136 A 946 946
111 China 13137 T 946 946
112 China 13138 C A 946 939 Ile4291Ile
113 China 13139 A 946 946
114 China 13140 C 946 946
115 China 13141 T A,C 946 938 Thr4292Thr-p.Thr4292Thr
116 China 13142 A 946 946
117 China 13143 A 946 946
118 China 13144 T C 946 945 Asn4293Asn
119 China 13145 T 946 946
120 China 13146 G 947 947
121 China 13147 T 947 947
122 China 13148 G 947 947
123 China 13149 T 947 947
124 China 13150 T G 947 946 Val4295Val
125 China 13151 A 947 947
126 China 13152 A 947 947
127 China 13153 G 947 947
128 China 13154 A 947 947
129 China 13155 T 947 947
130 China 13156 G 947 947
131 China 13157 T 947 947
132 China 13158 T 947 947
133 China 13159 G 947 947
134 China 13160 T 947 947
135 China 13161 G 947 947
136 China 13162 T C 947 946 Cys4299Cys
137 China 13163 A 947 947
138 China 13164 C 947 947
139 China 13165 A 947 947
140 China 13166 C 947 947
141 China 13167 A 947 947
142 China 13168 C T 947 941 His4301His
143 China 13169 A 947 946
144 China 13170 C T 947 946 Thr4302Ile
145 China 13171 T A 947 940 Thr4302Thr
146 China 13172 G 947 947
147 China 13173 G 947 947
148 China 13174 T 947 947
149 China 13175 A G 947 941 Thr4304Ala
150 China 13176 C 947 947
151 China 13177 T A 947 946 Thr4304Thr
152 China 13178 G 947 947
153 China 13179 G 947 947
154 China 13180 T A 947 946 Gly4305Gly
155 China 13181 C 947 947
156 China 13182 A 947 946
157 China 13183 G A 947 946 Gln4306Gln
158 China 13184 G 947 947
159 China 13185 C 947 947
160 China 13186 A 947 947
161 China 13187 A 947 947
162 China 13188 T 947 947
163 China 13189 A T 947 946 Ile4308Ile
164 China 13190 A 947 947
165 China 13191 C 947 947
166 China 13192 A T 947 939 Thr4309Thr
167 China 13193 G 947 947
168 China 13194 T 947 947
169 China 13195 T A 947 939 Val4310Val
170 China 13196 A 947 947
171 China 13197 C 947 947
172 China 13198 A 947 947
173 China 13199 C 947 947
174 China 13200 C 947 947
175 China 13201 G A 947 937 Pro4312Pro
176 China 13202 G 947 947
177 China 13203 A 947 947
178 China 13204 A 947 946
179 China 13205 G 947 947
180 China 13206 C 947 947
181 China 13207 C T 947 946 Ala4314Ala
182 China 13208 A 947 947
183 China 13209 A 947 947
184 China 13210 T C 947 946 Asn4315Asn
185 China 13211 A 947 947
186 China 13212 T 947 947
187 China 13213 G 947 947
188 China 13214 G 947 947
189 China 13215 A 947 947
190 China 13216 T C 947 946 Asp4317Asp
191 China 13217 C 947 947
192 China 13218 A 947 947
193 China 13219 A 947 947
194 China 13220 G 947 947
195 China 13221 A 947 947
196 China 13222 A 947 947
197 China 13223 T 947 947
198 China 13224 C 947 947
199 China 13225 C 947 947
200 China 13226 T 947 946
201 China 13227 T 947 947
202 China 13228 T 947 947
203 China 13229 G 947 947
204 China 13230 G 947 947
205 China 13231 T C 947 940 Gly4322Gly
206 China 13232 G 947 947
207 China 13233 G 947 947
208 China 13234 T 947 946
209 China 13235 G 947 946
210 China 13236 C 947 946
211 China 13237 A T 946 938 Ala4324Ala
212 China 13238 T 946 945
213 China 13239 C 946 945
214 China 13240 G T 946 938 Ser4325Ser
215 China 13241 T 946 946
216 China 13242 G 946 946
217 China 13243 T C 946 913 Cys4326Cys
218 China 13244 T 946 946
219 China 13245 G 946 946
220 China 13246 T C 946 939 Cys4327Cys
221 China 13247 C T 946 939 Leu4328Leu
222 China 13248 T 946 946
223 China 13249 G 946 946
224 China 13250 T 946 946
225 China 13251 A 946 946
226 China 13252 C 946 946
227 China 13253 T 946 946
228 China 13254 G 946 946
229 China 13255 C T 946 930 Cys4330Cys
230 China 13256 C A 946 939 Arg4331Ser
231 China 13257 G 946 946
232 China 13258 T A 946 939 Arg4331Arg
233 China 13259 T 946 946
234 China 13260 G 946 946
235 China 13261 C 946 946
236 China 13262 C 946 946
237 China 13263 A 946 946
238 China 13264 C 946 946
239 China 13265 A 946 946
240 China 13266 T 946 946
241 China 13267 A 946 946
242 China 13268 G 946 946
243 China 13269 A 946 946
244 China 13270 T C 946 940 Asp4335Asp
245 China 13271 C 946 946
246 China 13272 A 946 946
247 China 13273 T 946 946
248 China 13274 C 946 946
249 China 13275 C 946 946
250 China 13276 A T 946 938 Pro4337Pro
251 China 13277 A 946 945
252 China 13278 A 946 945
253 China 13279 T C 946 939 Asn4338Asn
254 China 13280 C 946 945
255 China 13281 C 946 945
256 China 13282 T 946 945
257 China 13283 A 945 944
258 China 13284 A 945 944
259 China 13285 A 945 944
260 China 13286 G 945 944
261 China 13287 G 945 944
262 China 13288 A T,G 945 932 Gly4341Gly-p.Gly4341Gly
263 China 13289 T 945 944
264 China 13290 T A 945 938 Phe4342Tyr
265 China 13291 T C 945 938 Phe4342Phe
266 China 13292 T 945 944
267 China 13293 G 945 944
268 China 13294 T 945 944
269 China 13295 G 945 945
270 China 13296 A 945 945
271 China 13297 C T,G 945 932 Asp4344Glu-p.Asp4344Asp
272 China 13298 T C 945 939 Leu4345Leu
273 China 13299 T 945 945
274 China 13300 A G,T 945 932 Leu4345Phe-p.Leu4345Leu
275 China 13301 A 945 945
276 China 13302 A 945 945
277 China 13303 A 945 945
278 China 13304 G 945 945
279 China 13305 G 945 945
280 China 13306 T 945 945
281 China 13307 A 945 945
282 China 13308 A 945 945
283 China 13309 G A 945 938 Lys4348Lys
284 China 13310 T 945 945
285 China 13311 A 945 945
286 China 13312 T 945 945
287 China 13313 G 945 945
288 China 13314 T 945 945
289 China 13315 A 945 945
290 China 13316 C 945 945
291 China 13317 A 945 945
292 China 13318 A 945 945
293 China 13319 A 945 945
294 China 13320 T 945 945
295 China 13321 A 945 945
296 China 13322 C 945 945
297 China 13323 C 945 945
298 China 13324 T 945 945
299 China 13325 A 945 945
300 China 13326 C 945 945
301 China 13327 A C,G 945 938 Thr4354Thr-p.Thr4354Thr
302 China 13328 A 945 945
303 China 13329 C 945 945
304 China 13330 T 945 945
305 China 13331 T 945 945
306 China 13332 G 945 945
307 China 13333 T 945 945
308 China 13334 G 945 945
309 China 13335 C 945 945
310 China 13336 T 944 944
311 China 13337 A 944 944
312 China 13338 A 944 944
313 China 13339 T 944 944
314 China 13340 G 944 944
315 China 13341 A 944 944
316 China 13342 C 944 944
317 China 13343 C 944 944
318 China 13344 C 944 944
319 China 13345 T A 944 938 Pro4360Pro
320 China 13346 G 944 944
321 China 13347 T 944 944
322 China 13348 G 944 944
323 China 13349 G 944 944
324 China 13350 G 944 944
325 China 13351 T 944 944
326 China 13352 T 944 944
327 China 13353 T 944 944
328 China 13354 T 944 944
329 China 13355 A 944 944
330 China 13356 C 944 944
331 China 13357 A 944 944
332 China 13358 C 944 944
333 China 13359 T 944 944
334 China 13360 T 944 944
335 China 13361 A 944 944
336 China 13362 A 944 944
337 China 13363 A 944 944
338 China 13364 A 944 944
339 China 13365 A 944 943
340 China 13366 C 944 944
341 China 13367 A 944 943
342 China 13368 C 944 944
343 China 13369 A 944 944
344 China 13370 G 944 944
345 China 13371 T 944 944
346 China 13372 C 944 944
347 China 13373 T 944 944
348 China 13374 G 944 944
349 China 13375 T 944 944
350 China 13376 A 944 944
351 China 13377 C 944 944
352 China 13378 C 944 944
353 China 13379 G 920 920
354 China 13380 T 920 920
355 China 13381 C 920 919
356 China 13382 T 920 920
357 China 13383 G 920 920
358 China 13384 C 920 919
359 China 13385 G 920 918
360 China 13386 G 920 919
361 China 13387 T C 920 913 Gly4374Gly
362 China 13388 A 920 920
363 China 13389 T 920 919
364 China 13390 G 920 919
365 China 13391 T 920 919
366 China 13392 G 920 919
367 China 13393 G 920 920
368 China 13394 A 920 920
369 China 13395 A 920 919
370 China 13396 A 920 919
371 China 13397 G 920 919
372 China 13398 G 920 919
373 China 13399 T 920 919
374 China 13400 T 920 919
375 China 13401 A 920 919
376 China 13402 T G 920 916 Tyr4379*
377 China 13403 G 920 919
378 China 13404 G 920 920
379 China 13405 C 920 919
380 China 13406 T 920 919
381 China 13407 G 920 918
382 China 13408 T 920 919
383 China 13409 A 919 917
384 China 13410 G 918 917
385 China 13411 T 917 916
386 China 13412 T 916 915
387 China 13413 G 916 915
388 China 13414 T 916 915
389 China 13415 G 916 916
390 China 13416 A 916 916
391 China 13417 T 916 916
392 China 13418 C 916 916
393 China 13419 A 916 915
394 China 13420 A 916 916
395 China 13421 C 916 916
396 China 13422 T 915 909
397 China 13423 C 915 915
398 China 13424 C 915 914
399 China 13425 G 915 914
400 China 13426 C 915 915
401 China 13427 G 915 915
402 China 13428 A 915 915
403 China 13429 A 915 915
404 China 13430 C 915 914
405 China 13431 C 915 914
406 China 13432 C T 915 909 Pro4389Pro
407 China 13433 A 915 915
408 China 13434 T 915 915
409 China 13435 G 915 915
410 China 13436 C 915 914
411 China 13437 T 914 913
412 China 13438 T A 914 913 Leu4391Leu
413 China 13439 C 914 914
414 China 13440 A 914 914
415 China 13441 G 914 914