National Institute Of Genetic Engineering and Biotechnology

P.I:Mohammad-Ali Malboobi
Here we provide last mutation observed in Nucleocapsid gene of COVID-19 prevalent in Iran.
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Amino acid changes

How to read this table:
- Rows are reference amino acids and columns are changed amino acids. E.g. Row 'A' column 'E' indicates how many 'A' amino acids have been replaced by 'E' amino acids.
- Red background colors indicate that more changes happened (heat-map).
- Diagonals are indicated using grey background color
- WARNING: This table may include different translation codon tables (e.g. mamalian DNA and mitochondrial DNA).

  * - ? A C D E F H I K L M N P Q R S T V W Y
*     2                                      
-     186                                      
?                                            
A     3 1                                    
C                                            
D     12     1               2               2
E 3   16     3                           1    
F     9         3                   1        
H     3     1                               1
I     30             1   1             2 3    
K     12               1                      
L     24             1   3     1              
M     9             1                 1      
N     12               1     2                
P     3                 1     2              
Q     9                         2            
R     3                   1         1        
S     12         1                   2        
T     9 1           1                 1      
V     9         1   1                        
W     3                 1                    
Y     6   1     1 2                         1

Nucleotide and amino acid mutations

Here we provide list of mutation observed in Nucleocapsid at gene and protein of COVID-19.
-The position column is nucleotide position in reference genome as NC_045512.2
-The Reference column indicate reference nucleotide in NC_045512.2
-The NS column indicate number of samples that this position have been observed
-The NSR column indicate number of samples with reference nucleotide. Therefore diffrenciate related to Ns indicate number of sample with mutated nucleotide
Contoury Position Reference Alt. NSR NS AAchange
0 Switzerland 27202 A 8007 8007
1 Switzerland 27203 T 8007 8007
2 Switzerland 27204 G T 8007 8006 Met1?
3 Switzerland 27205 T 8007 8005
4 Switzerland 27206 T C 8007 8004 Phe2Ser
5 Switzerland 27207 T C 8007 8005 Phe2Phe
6 Switzerland 27208 C G,T 8007 7997 His3Asp-p.His3Tyr
7 Switzerland 27209 A 8007 8007
8 Switzerland 27210 T 8007 8007
9 Switzerland 27211 C 8007 8007
10 Switzerland 27212 T C 8007 8004 Leu4Pro
11 Switzerland 27213 C T 8007 7996 Leu4Leu
12 Switzerland 27214 G A 8007 7997 Val5Ile
13 Switzerland 27215 T 8007 8007
14 Switzerland 27216 T 8007 8003
15 Switzerland 27217 G A 8007 8005 Asp6Asn
16 Switzerland 27218 A 8007 8006
17 Switzerland 27219 C 8007 8002
18 Switzerland 27220 T 8007 8007
19 Switzerland 27221 T 8007 8006
20 Switzerland 27222 T C 8007 8006 Phe7Phe
21 Switzerland 27223 C 8007 8004
22 Switzerland 27224 A 8007 8005
23 Switzerland 27225 G A 8007 8003 Gln8Gln
24 Switzerland 27226 G T 8007 8002 Val9Phe
25 Switzerland 27227 T 8007 8007
26 Switzerland 27228 T 8008 8007
27 Switzerland 27229 A 8008 8008
28 Switzerland 27230 C 8008 8005
29 Switzerland 27231 T C 8008 8007 Thr10Thr
30 Switzerland 27232 A 8008 8007
31 Switzerland 27233 T 8008 8008
32 Switzerland 27234 A 8008 8007
33 Switzerland 27235 G 8008 8006
34 Switzerland 27236 C 8008 8008
35 Switzerland 27237 A G 8008 8003 Ala12Ala
36 Switzerland 27238 G T 8007 8004 Glu13*
37 Switzerland 27239 A 8008 8008
38 Switzerland 27240 G T 8008 8000 Glu13Asp
39 Switzerland 27241 A G 8008 8005 Ile14Val
40 Switzerland 27242 T 8007 8007
41 Switzerland 27243 A 8007 8007
42 Switzerland 27244 T 8007 8006
43 Switzerland 27245 T 8007 8005
44 Switzerland 27246 A 8007 8005
45 Switzerland 27247 C T 8007 8000 Leu16Leu
46 Switzerland 27248 T 8007 8007
47 Switzerland 27249 A 8007 8006
48 Switzerland 27250 A 8007 8007
49 Switzerland 27251 T 8007 8007
50 Switzerland 27252 T 8007 8007
51 Switzerland 27253 A G 8006 8004 Ile18Val
52 Switzerland 27254 T 8006 8005
53 Switzerland 27255 T 8006 8006
54 Switzerland 27256 A 8006 8005
55 Switzerland 27257 T 8006 8006
56 Switzerland 27258 G 8006 8006
57 Switzerland 27259 A 8006 8006
58 Switzerland 27260 G T 8006 8005 Arg20Met
59 Switzerland 27261 G T 8006 8000 Arg20Ser
60 Switzerland 27262 A G 8004 8003 Thr21Ala
61 Switzerland 27263 C T 8004 8000 Thr21Ile
62 Switzerland 27264 T 8004 7998
63 Switzerland 27265 T 8004 8003
64 Switzerland 27266 T 8003 8003
65 Switzerland 27267 T C 8003 8002 Phe22Phe
66 Switzerland 27268 A 8003 8001
67 Switzerland 27269 A 8003 8003
68 Switzerland 27270 A 8003 8001
69 Switzerland 27271 G 8003 8002
70 Switzerland 27272 T 8003 8003
71 Switzerland 27273 T 8003 8003
72 Switzerland 27274 T 8003 8001
73 Switzerland 27275 C 8003 8003
74 Switzerland 27276 C 8003 7999
75 Switzerland 27277 A G 8003 7999 Ile26Val
76 Switzerland 27278 T 8003 8001
77 Switzerland 27279 T 8003 8003
78 Switzerland 27280 T 8004 8004
79 Switzerland 27281 G T 8004 7997 Trp27Leu
80 Switzerland 27282 G 8006 8005
81 Switzerland 27283 A 8018 8017
82 Switzerland 27284 A 8018 8016
83 Switzerland 27285 T C 8018 8017 Asn28Asn
84 Switzerland 27286 C 8017 8015
85 Switzerland 27287 T 8017 8017
86 Switzerland 27288 T 8017 8015
87 Switzerland 27289 G 8018 8015
88 Switzerland 27290 A 8018 8018
89 Switzerland 27291 T 8018 8016
90 Switzerland 27292 T C 8018 8016 Tyr31His
91 Switzerland 27293 A 8019 8019
92 Switzerland 27294 C T 8019 8010 Tyr31Tyr
93 Switzerland 27295 A 8019 8019
94 Switzerland 27296 T 8019 8016
95 Switzerland 27297 C T 8019 7961 Ile32Ile
96 Switzerland 27298 A T 8019 8018 Ile33Leu
97 Switzerland 27299 T C 8020 8015 Ile33Thr
98 Switzerland 27300 A 8020 8018
99 Switzerland 27301 A 8020 8019
100 Switzerland 27302 A 8020 8018
101 Switzerland 27303 C T,A 8020 8005 Asn34Lys-p.Asn34Asn
102 Switzerland 27304 C A 8020 8019 Leu35Ile
103 Switzerland 27305 T 8020 8020
104 Switzerland 27306 C 8020 8017
105 Switzerland 27307 A 8020 8020
106 Switzerland 27308 T C 8020 8017 Ile36Thr
107 Switzerland 27309 A 8020 8019
108 Switzerland 27310 A 8020 8020
109 Switzerland 27311 T 8020 8019
110 Switzerland 27312 T 8020 8017
111 Switzerland 27313 A 8020 8018
112 Switzerland 27314 A 8020 8020
113 Switzerland 27315 A 8020 8020
114 Switzerland 27316 A 8020 8020
115 Switzerland 27317 A 8020 8020
116 Switzerland 27318 T 8020 8018
117 Switzerland 27319 T C 8020 7505 Leu40Leu
118 Switzerland 27320 T 8020 8020
119 Switzerland 27321 A 8021 8021
120 Switzerland 27322 T 8023 8021
121 Switzerland 27323 C T 8023 8012 Ser41Phe
122 Switzerland 27324 T C 8023 8022 Ser41Ser
123 Switzerland 27325 A 8023 8023
124 Switzerland 27326 A 8023 8023
125 Switzerland 27327 G A 8023 8015 Lys42Lys
126 Switzerland 27328 T 8023 8023
127 Switzerland 27329 C 8022 8018
128 Switzerland 27330 A 8022 8021
129 Switzerland 27331 C 8022 8022
130 Switzerland 27332 T 8022 8020
131 Switzerland 27333 A 8022 8020
132 Switzerland 27334 A 8022 8022
133 Switzerland 27335 C 8022 8019
134 Switzerland 27336 T 8022 8022
135 Switzerland 27337 G 8022 8020
136 Switzerland 27338 A 8022 8021
137 Switzerland 27339 G 8022 8021
138 Switzerland 27340 A 8022 8021
139 Switzerland 27341 A 8022 8021
140 Switzerland 27342 T 8022 8020
141 Switzerland 27343 A 8022 8019
142 Switzerland 27344 A 8022 8020
143 Switzerland 27345 A 8022 8021
144 Switzerland 27346 T C 8022 8020 Tyr49His
145 Switzerland 27347 A T,G 8021 8017 Tyr49Phe-p.Tyr49Cys
146 Switzerland 27348 T 8021 8019
147 Switzerland 27349 T 8021 8019
148 Switzerland 27350 C 8021 8019
149 Switzerland 27351 T C 8021 8017 Ser50Ser
150 Switzerland 27352 C 8021 8017
151 Switzerland 27353 A 8021 8020
152 Switzerland 27354 A G 8021 8018 Gln51Gln
153 Switzerland 27355 T 8021 8020
154 Switzerland 27356 T 8021 8018
155 Switzerland 27357 A 8021 8019
156 Switzerland 27358 G T 8021 8017 Asp53Tyr
157 Switzerland 27359 A 8021 8021
158 Switzerland 27360 T 8021 8021
159 Switzerland 27361 G 8021 8021
160 Switzerland 27362 A 8021 8019
161 Switzerland 27363 A 8021 8019
162 Switzerland 27364 G T 8021 8017 Glu55*
163 Switzerland 27365 A T 8021 8015 Glu55Val
164 Switzerland 27366 G T 8021 8017 Glu55Asp
165 Switzerland 27367 C 8021 8020
166 Switzerland 27368 A 8021 8019
167 Switzerland 27369 A 8021 8019
168 Switzerland 27370 C 8021 8018
169 Switzerland 27371 C T 8021 8014 Pro57Leu
170 Switzerland 27372 A T,G 8021 8009 Pro57Pro-p.Pro57Pro
171 Switzerland 27373 A 8021 8020
172 Switzerland 27374 T C 8020 8017 Met58Thr
173 Switzerland 27375 G 8020 8019
174 Switzerland 27376 G T 8020 8019 Glu59*
175 Switzerland 27377 A 8020 8019
176 Switzerland 27378 G T 8020 8019 Glu59Asp
177 Switzerland 27379 A 8019 8019
178 Switzerland 27380 T 8018 8016
179 Switzerland 27381 T 8018 8017
180 Switzerland 27382 G T,A 8017 8005 Asp61Tyr-p.Asp61Asn
181 Switzerland 27383 A 8017 8016
182 Switzerland 27384 T C 8017 7979 Asp61Asp
183 Switzerland 27385 T 8017 8016
184 Switzerland 27386 A 8017 8016
185 Switzerland 27387 A 8017 8017