National Institute Of Genetic Engineering and Biotechnology

P.I:Mohammad-Ali Malboobi
Here we provide last mutation observed in Nucleocapsid gene of COVID-19 prevalent in Iran.
We kindly wait your comment or coopration in tracking crona virus project.

Amino acid changes

How to read this table:
- Rows are reference amino acids and columns are changed amino acids. E.g. Row 'A' column 'E' indicates how many 'A' amino acids have been replaced by 'E' amino acids.
- Red background colors indicate that more changes happened (heat-map).
- Diagonals are indicated using grey background color
- WARNING: This table may include different translation codon tables (e.g. mamalian DNA and mitochondrial DNA).

  * - ? A C D E F G H I K L M N P Q R S T V W Y
*     2                                        
-     186                                        
?                                              
A     3                                        
C                                              
D     12     2     1                           2
E     16 1   1     1                       1    
F     9         1         1           1        
G                                              
H     3                                       1
I     30               1                 2 1    
K     12                       2     2          
L     24         1         4                    
M     9                                   1    
N     12                       1       1        
P     3                                        
Q 2   9                                        
R     3                               1        
S     12   1                     1     1        
T     9               2                        
V     9         1                         1    
W     3                   1                    
Y     6             1                         1

Nucleotide and amino acid mutations

Here we provide list of mutation observed in Nucleocapsid at gene and protein of COVID-19.
-The position column is nucleotide position in reference genome as NC_045512.2
-The Reference column indicate reference nucleotide in NC_045512.2
-The NS column indicate number of samples that this position have been observed
-The NSR column indicate number of samples with reference nucleotide. Therefore diffrenciate related to Ns indicate number of sample with mutated nucleotide

Contoury Position Reference Alt. NSR NS AAchange
0 Netherlands 27202 A 5880 5880
1 Netherlands 27203 T 5883 5883
2 Netherlands 27204 G 5883 5883
3 Netherlands 27205 T 5883 5883
4 Netherlands 27206 T 5883 5883
5 Netherlands 27207 T 5883 5883
6 Netherlands 27208 C T 5883 5878 His3Tyr
7 Netherlands 27209 A 5883 5883
8 Netherlands 27210 T 5883 5883
9 Netherlands 27211 C 5883 5883
10 Netherlands 27212 T 5883 5883
11 Netherlands 27213 C T 5883 5866 Leu4Leu
12 Netherlands 27214 G T 5883 5880 Val5Phe
13 Netherlands 27215 T 5883 5883
14 Netherlands 27216 T 5883 5883
15 Netherlands 27217 G 5883 5883
16 Netherlands 27218 A 5883 5882
17 Netherlands 27219 C T 5883 5882 Asp6Asp
18 Netherlands 27220 T C 5883 5880 Phe7Leu
19 Netherlands 27221 T C 5883 5882 Phe7Ser
20 Netherlands 27222 T 5883 5883
21 Netherlands 27223 C T 5883 5882 Gln8*
22 Netherlands 27224 A 5883 5883
23 Netherlands 27225 G 5883 5883
24 Netherlands 27226 G 5883 5883
25 Netherlands 27227 T 5883 5883
26 Netherlands 27228 T C 5883 5882 Val9Val
27 Netherlands 27229 A 5883 5883
28 Netherlands 27230 C T 5883 5882 Thr10Ile
29 Netherlands 27231 T 5883 5883
30 Netherlands 27232 A 5883 5883
31 Netherlands 27233 T 5883 5883
32 Netherlands 27234 A 5883 5883
33 Netherlands 27235 G 5883 5883
34 Netherlands 27236 C 5883 5883
35 Netherlands 27237 A 5883 5883
36 Netherlands 27238 G 5883 5883
37 Netherlands 27239 A 5883 5883
38 Netherlands 27240 G 5883 5883
39 Netherlands 27241 A 5883 5883
40 Netherlands 27242 T 5883 5883
41 Netherlands 27243 A 5883 5883
42 Netherlands 27244 T 5883 5883
43 Netherlands 27245 T 5883 5883
44 Netherlands 27246 A 5883 5883
45 Netherlands 27247 C T 5883 5877 Leu16Leu
46 Netherlands 27248 T 5883 5883
47 Netherlands 27249 A 5883 5883
48 Netherlands 27250 A 5883 5883
49 Netherlands 27251 T 5883 5883
50 Netherlands 27252 T 5883 5883
51 Netherlands 27253 A 5883 5883
52 Netherlands 27254 T 5883 5883
53 Netherlands 27255 T 5883 5883
54 Netherlands 27256 A 5883 5883
55 Netherlands 27257 T 5883 5883
56 Netherlands 27258 G 5883 5883
57 Netherlands 27259 A 5883 5883
58 Netherlands 27260 G 5883 5883
59 Netherlands 27261 G T 5883 5838 Arg20Ser
60 Netherlands 27262 A 5883 5883
61 Netherlands 27263 C T 5883 5880 Thr21Ile
62 Netherlands 27264 T 5883 5883
63 Netherlands 27265 T 5883 5883
64 Netherlands 27266 T 5883 5883
65 Netherlands 27267 T C 5883 5882 Phe22Phe
66 Netherlands 27268 A 5883 5883
67 Netherlands 27269 A G 5883 5852 Lys23Arg
68 Netherlands 27270 A T 5883 5852 Lys23Asn
69 Netherlands 27271 G 5883 5883
70 Netherlands 27272 T 5883 5883
71 Netherlands 27273 T 5883 5883
72 Netherlands 27274 T C 5883 5882 Ser25Pro
73 Netherlands 27275 C 5883 5883
74 Netherlands 27276 C 5883 5883
75 Netherlands 27277 A G 5883 5882 Ile26Val
76 Netherlands 27278 T 5883 5883
77 Netherlands 27279 T 5883 5883
78 Netherlands 27280 T 5883 5883
79 Netherlands 27281 G T 5883 5878 Trp27Leu
80 Netherlands 27282 G 5883 5883
81 Netherlands 27283 A 5883 5883
82 Netherlands 27284 A 5883 5883
83 Netherlands 27285 T 5883 5883
84 Netherlands 27286 C T 5883 5882 Leu29Phe
85 Netherlands 27287 T 5883 5883
86 Netherlands 27288 T 5883 5883
87 Netherlands 27289 G 5883 5883
88 Netherlands 27290 A 5883 5883
89 Netherlands 27291 T 5883 5883
90 Netherlands 27292 T 5883 5883
91 Netherlands 27293 A 5883 5883
92 Netherlands 27294 C T 5883 5882 Tyr31Tyr
93 Netherlands 27295 A 5883 5883
94 Netherlands 27296 T 5883 5883
95 Netherlands 27297 C T 5883 5881 Ile32Ile
96 Netherlands 27298 A 5883 5883
97 Netherlands 27299 T C 5883 5882 Ile33Thr
98 Netherlands 27300 A 5883 5883
99 Netherlands 27301 A 5883 5883
100 Netherlands 27302 A 5883 5883
101 Netherlands 27303 C 5883 5883
102 Netherlands 27304 C 5883 5883
103 Netherlands 27305 T 5882 5882
104 Netherlands 27306 C 5882 5882
105 Netherlands 27307 A 5882 5882
106 Netherlands 27308 T C 5882 5881 Ile36Thr
107 Netherlands 27309 A 5882 5882
108 Netherlands 27310 A 5882 5882
109 Netherlands 27311 T 5882 5882
110 Netherlands 27312 T 5882 5882
111 Netherlands 27313 A 5882 5882
112 Netherlands 27314 A G 5882 5881 Lys38Arg
113 Netherlands 27315 A 5882 5882
114 Netherlands 27316 A 5882 5882
115 Netherlands 27317 A 5882 5882
116 Netherlands 27318 T 5882 5882
117 Netherlands 27319 T C 5882 5879 Leu40Leu
118 Netherlands 27320 T 5882 5882
119 Netherlands 27321 A 5882 5882
120 Netherlands 27322 T 5882 5882
121 Netherlands 27323 C G 5882 5881 Ser41Cys
122 Netherlands 27324 T C 5882 5881 Ser41Ser
123 Netherlands 27325 A 5882 5882
124 Netherlands 27326 A 5882 5882
125 Netherlands 27327 G 5882 5882
126 Netherlands 27328 T 5882 5882
127 Netherlands 27329 C 5882 5882
128 Netherlands 27330 A 5882 5882
129 Netherlands 27331 C 5882 5882
130 Netherlands 27332 T 5882 5882
131 Netherlands 27333 A 5882 5882
132 Netherlands 27334 A 5882 5882
133 Netherlands 27335 C 5882 5882
134 Netherlands 27336 T 5882 5882
135 Netherlands 27337 G 5882 5882
136 Netherlands 27338 A G 5882 5881 Glu46Gly
137 Netherlands 27339 G T 5882 5881 Glu46Asp
138 Netherlands 27340 A 5882 5882
139 Netherlands 27341 A G 5882 5881 Asn47Ser
140 Netherlands 27342 T C 5882 5730 Asn47Asn
141 Netherlands 27343 A 5882 5882
142 Netherlands 27344 A 5882 5882
143 Netherlands 27345 A T 5882 5880 Lys48Asn
144 Netherlands 27346 T C 5882 5881 Tyr49His
145 Netherlands 27347 A 5882 5882
146 Netherlands 27348 T 5882 5882
147 Netherlands 27349 T 5882 5882
148 Netherlands 27350 C 5882 5882
149 Netherlands 27351 T 5882 5882
150 Netherlands 27352 C 5882 5882
151 Netherlands 27353 A 5882 5882
152 Netherlands 27354 A 5882 5882
153 Netherlands 27355 T C 5882 5881 Leu52Leu
154 Netherlands 27356 T 5882 5882
155 Netherlands 27357 A 5882 5882
156 Netherlands 27358 G T 5882 5881 Asp53Tyr
157 Netherlands 27359 A 5882 5882
158 Netherlands 27360 T 5882 5882
159 Netherlands 27361 G 5882 5882
160 Netherlands 27362 A 5882 5882
161 Netherlands 27363 A 5882 5882
162 Netherlands 27364 G 5882 5882
163 Netherlands 27365 A C,T 5882 5874 Glu55Ala-p.Glu55Val
164 Netherlands 27366 G 5882 5882
165 Netherlands 27367 C T 5882 5881 Gln56*
166 Netherlands 27368 A 5882 5882
167 Netherlands 27369 A 5882 5882
168 Netherlands 27370 C 5882 5882
169 Netherlands 27371 C 5882 5882
170 Netherlands 27372 A 5882 5882
171 Netherlands 27373 A G 5882 5875 Met58Val
172 Netherlands 27374 T 5882 5882
173 Netherlands 27375 G 5882 5882
174 Netherlands 27376 G 5882 5882
175 Netherlands 27377 A 5882 5882
176 Netherlands 27378 G 5882 5882
177 Netherlands 27379 A 5882 5882
178 Netherlands 27380 T 5882 5882
179 Netherlands 27381 T 5882 5882
180 Netherlands 27382 G T 5880 5879 Asp61Tyr
181 Netherlands 27383 A G 5880 5879 Asp61Gly
182 Netherlands 27384 T C 5880 5859 Asp61Asp
183 Netherlands 27385 T 5880 5880
184 Netherlands 27386 A 5880 5880
185 Netherlands 27387 A 5880 5880