National Institute Of Genetic Engineering and Biotechnology

P.I:Mohammad-Ali Malboobi
Here we provide last mutation observed in Nucleocapsid gene of COVID-19 prevalent in Iran.
We kindly wait your comment or coopration in tracking crona virus project.
Amino acid changes

How to read this table:
- Rows are reference amino acids and columns are changed amino acids. E.g. Row 'A' column 'E' indicates how many 'A' amino acids have been replaced by 'E' amino acids.
- Red background colors indicate that more changes happened (heat-map).
- Diagonals are indicated using grey background color
- WARNING: This table may include different translation codon tables (e.g. mamalian DNA and mitochondrial DNA).

  * - ? A D E F H I K L M N P Q R S T V W Y
*     2                                    
-     185                                    
?                                          
A     3                                    
D     12   3                                
E     16     1                              
F     9       1                            
H     3                                    
I     30           3                   1    
K     12             2                      
L     23       2   1   6           1   1    
M     9                                    
N     12                   3       1        
P     3                                    
Q     9         1             1            
R     3                         1          
S     12                     1     1        
T     9                                    
V     9       1   1                        
W     3                                    
Y     6                                    

Nucleotide and amino acid mutations

Here we provide list of mutation observed in Nucleocapsid at gene and protein of COVID-19.
-The position column is nucleotide position in reference genome as NC_045512.2
-The Reference column indicate reference nucleotide in NC_045512.2
-The NS column indicate number of samples that this position have been observed
-The NSR column indicate number of samples with reference nucleotide. Therefore diffrenciate related to Ns indicate number of sample with mutated nucleotide
Contoury Position Reference Alt. NSR NS AAchange
0 China 27202 A 945 945
1 China 27203 T 945 945
2 China 27204 G 945 945
3 China 27205 T 945 945
4 China 27206 T 945 945
5 China 27207 T 945 944
6 China 27208 C 945 945
7 China 27209 A 945 945
8 China 27210 T 945 945
9 China 27211 C 945 945
10 China 27212 T 945 945
11 China 27213 C T 945 927 Leu4Leu
12 China 27214 G 945 945
13 China 27215 T 945 945
14 China 27216 T 945 945
15 China 27217 G 945 945
16 China 27218 A 945 945
17 China 27219 C 945 945
18 China 27220 T 945 945
19 China 27221 T 945 945
20 China 27222 T 945 945
21 China 27223 C 945 945
22 China 27224 A 945 945
23 China 27225 G T 945 941 Gln8His
24 China 27226 G T 945 944 Val9Phe
25 China 27227 T 945 945
26 China 27228 T 945 945
27 China 27229 A 945 944
28 China 27230 C 945 944
29 China 27231 T 945 944
30 China 27232 A 945 944
31 China 27233 T 945 944
32 China 27234 A 945 943
33 China 27235 G 945 943
34 China 27236 C 945 943
35 China 27237 A 945 944
36 China 27238 G 945 944
37 China 27239 A 945 945
38 China 27240 G 945 945
39 China 27241 A 945 945
40 China 27242 T 945 945
41 China 27243 A 945 945
42 China 27244 T C 945 939 Leu15Leu
43 China 27245 T 945 945
44 China 27246 A T 945 939 Leu15Phe
45 China 27247 C T,A,G 946 930 Leu16Val-p.Leu16Leu
46 China 27248 T 946 946
47 China 27249 A T 946 940 Leu16Leu
48 China 27250 A G 946 945 Ile17Val
49 China 27251 T 946 946
50 China 27252 T 946 946
51 China 27253 A 946 946
52 China 27254 T 946 946
53 China 27255 T 946 946
54 China 27256 A 946 946
55 China 27257 T 946 946
56 China 27258 G 946 946
57 China 27259 A 946 945
58 China 27260 G 946 945
59 China 27261 G A 946 926 Arg20Arg
60 China 27262 A 945 943
61 China 27263 C 945 942
62 China 27264 T 945 939
63 China 27265 T 945 941
64 China 27266 T 945 941
65 China 27267 T C 945 932 Phe22Phe
66 China 27268 A 945 941
67 China 27269 A 945 941
68 China 27270 A G 945 934 Lys23Lys
69 China 27271 G A 945 934 Val24Ile
70 China 27272 T 945 941
71 China 27273 T 945 941
72 China 27274 T 945 941
73 China 27275 C 945 941
74 China 27276 C 945 941
75 China 27277 A 945 942
76 China 27278 T 945 942
77 China 27279 T 945 942
78 China 27280 T 945 942
79 China 27281 G 945 941
80 China 27282 G 945 942
81 China 27283 A 945 942
82 China 27284 A 945 942
83 China 27285 T C 945 934 Asn28Asn
84 China 27286 C 945 942
85 China 27287 T 945 942
86 China 27288 T 945 942
87 China 27289 G 945 942
88 China 27290 A 945 942
89 China 27291 T C 945 936 Asp30Asp
90 China 27292 T 945 943
91 China 27293 A 945 943
92 China 27294 C 945 943
93 China 27295 A 945 943
94 China 27296 T 945 944
95 China 27297 C T 945 942 Ile32Ile
96 China 27298 A 945 944
97 China 27299 T 945 944
98 China 27300 A T,C 945 936 Ile33Ile-p.Ile33Ile
99 China 27301 A 945 944
100 China 27302 A 945 944
101 China 27303 C T 945 931 Asn34Asn
102 China 27304 C T 945 943 Leu35Phe
103 China 27305 T 945 944
104 China 27306 C T 945 942 Leu35Leu
105 China 27307 A 945 944
106 China 27308 T 945 944
107 China 27309 A 945 943
108 China 27310 A 945 943
109 China 27311 T 945 944
110 China 27312 T 945 944
111 China 27313 A 945 944
112 China 27314 A 945 944
113 China 27315 A G 945 942 Lys38Lys
114 China 27316 A 945 944
115 China 27317 A G 945 936 Asn39Ser
116 China 27318 T C 945 943 Asn39Asn
117 China 27319 T 945 944
118 China 27320 T 945 944
119 China 27321 A 945 944
120 China 27322 T 946 945
121 China 27323 C 946 946
122 China 27324 T 946 946
123 China 27325 A 946 946
124 China 27326 A 946 946
125 China 27327 G 946 946
126 China 27328 T C 946 931 Ser43Pro
127 China 27329 C 946 945
128 China 27330 A T 946 940 Ser43Ser
129 China 27331 C T 946 940 Leu44Leu
130 China 27332 T 946 946
131 China 27333 A 946 946
132 China 27334 A 946 945
133 China 27335 C 946 945
134 China 27336 T 945 945
135 China 27337 G 945 945
136 China 27338 A 945 945
137 China 27339 G A 945 931 Glu46Glu
138 China 27340 A 945 945
139 China 27341 A 945 945
140 China 27342 T 945 945
141 China 27343 A 945 945
142 China 27344 A 945 945
143 China 27345 A 945 945
144 China 27346 T 945 945
145 China 27347 A 945 945
146 China 27348 T 945 945
147 China 27349 T 945 945
148 China 27350 C 945 945
149 China 27351 T 945 945
150 China 27352 C 945 945
151 China 27353 A 945 945
152 China 27354 A G 945 931 Gln51Gln
153 China 27355 T 945 945
154 China 27356 T C 945 944 Leu52Ser
155 China 27357 A 945 945
156 China 27358 G 945 945
157 China 27359 A 945 945
158 China 27360 T C 945 939 Asp53Asp
159 China 27361 G 945 944
160 China 27362 A 945 944
161 China 27363 A 945 944
162 China 27364 G 945 944
163 China 27365 A 945 944
164 China 27366 G 945 944
165 China 27367 C 945 944
166 China 27368 A 944 943
167 China 27369 A 944 944
168 China 27370 C 944 944
169 China 27371 C 944 944
170 China 27372 A 944 944
171 China 27373 A 944 944
172 China 27374 T 944 944
173 China 27375 G 944 944
174 China 27376 G 944 944
175 China 27377 A 944 944
176 China 27378 G 944 944
177 China 27379 A 944 942
178 China 27380 T 944 944
179 China 27381 T 944 944
180 China 27382 G 943 943
181 China 27383 A 943 942
182 China 27384 T C 943 942 Asp61Asp
183 China 27385 T 943 943
184 China 27386 A 943 943
185 China 27387 A 943 943